Gap Junctions

"Gap Junctions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of CONNEXINS, the family of proteins which form the junctions.

Descriptor ID	D017629
MeSH Number(s)	A11.284.149.165.420.471
Concept/Terms	Gap Junctions Gap Junctions Gap Junction Junction, Gap Junctions, Gap

Below are MeSH descriptors whose meaning is more general than "Gap Junctions".

Anatomy [A]
Cells [A11]
Cellular Structures [A11.284]
Cell Membrane [A11.284.149]
Cell Membrane Structures [A11.284.149.165]
Intercellular Junctions [A11.284.149.165.420]
Gap Junctions [A11.284.149.165.420.471]

Below are MeSH descriptors whose meaning is related to "Gap Junctions".

Below are MeSH descriptors whose meaning is more specific than "Gap Junctions".

Gap Junctions
Electrical Synapses

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gap Junctions" by people in this website by year, and whether "Gap Junctions" was a major or minor topic of these publications.

Bar chart showing 54 publications over 25 distinct years, with a maximum of 7 publications in 2001

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1999	1	0	1
2000	0	1	1
2001	3	4	7
2002	1	0	1
2003	3	2	5
2004	0	3	3
2005	1	5	6
2006	0	3	3
2007	4	0	4
2008	0	3	3
2009	0	1	1
2010	0	1	1
2011	1	0	1
2012	3	0	3
2013	0	1	1
2014	1	0	1
2015	1	0	1
2017	1	0	1
2018	2	1	3
2019	0	1	1
2020	1	0	1
2021	0	1	1
2022	0	1	1
2024	1	1	2

Below are the most recent publications written about "Gap Junctions" by people in Profiles.

Das S, Shaw AK, Das Sarma S, Koval M, Das Sarma J, Maulik M. Neurotropic Murine ?-Coronavirus Infection Causes Differential Expression of Connexin 47 in Oligodendrocyte Subpopulations Associated with Demyelination. Mol Neurobiol. 2025 Mar; 62(3):3428-3445.

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Karmakar S, Das Sarma J. Human coronavirus OC43 infection remodels connexin 43-mediated gap junction intercellular communication in vitro. J Virol. 2024 Jul 23; 98(7):e0047824.

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Bose A, Kasle G, Jana R, Maulik M, Thomas D, Mulchandani V, Mukherjee P, Koval M, Das Sarma J. Regulatory role of endoplasmic reticulum resident chaperone protein ERp29 in anti-murine ?-coronavirus host cell response. J Biol Chem. 2023 02; 299(2):102836.

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Sinha G, Ferrer AI, Ayer S, El-Far MH, Pamarthi SH, Naaldijk Y, Barak P, Sandiford OA, Bibber BM, Yehia G, Greco SJ, Jiang JG, Bryan M, Kumar R, Ponzio NM, Etchegaray JP, Rameshwar P. Specific N-cadherin-dependent pathways drive human breast cancer dormancy in bone marrow. Life Sci Alliance. 2021 07; 4(7).

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Maulik M, Vasan L, Bose A, Dutta Chowdhury S, Sengupta N, Das Sarma J. Amyloid-? regulates gap junction protein connexin 43 trafficking in cultured primary astrocytes. J Biol Chem. 2020 10 30; 295(44):15097-15111.

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Bazzoun D, Adissu HA, Wang L, Urazaev A, Tenvooren I, Fostok SF, Chittiboyina S, Sturgis J, Hodges K, Chandramouly G, Vidi PA, Talhouk RS, Leli?vre SA. Connexin 43 maintains tissue polarity and regulates mitotic spindle orientation in the breast epithelium. J Cell Sci. 2019 05 16; 132(10).

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Boldog E, Bakken TE, Hodge RD, Novotny M, Aevermann BD, Baka J, Bord? S, Close JL, Diez-Fuertes F, Ding SL, Farag? N, Kocsis ?K, Kov?cs B, Maltzer Z, McCorrison JM, Miller JA, Moln?r G, Ol?h G, Ozsv?r A, R?zsa M, Shehata SI, Smith KA, Sunkin SM, Tran DN, Venepally P, Wall A, Pusk?s LG, Barz? P, Steemers FJ, Schork NJ, Scheuermann RH, Lasken RS, Lein ES, Tam?s G. Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type. Nat Neurosci. 2018 09; 21(9):1185-1195.

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Mohanty I, Parija SC, Suklabaidya S, Rattan S. Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery. Eur J Pharmacol. 2018 May 15; 827:22-31.

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Bose A, Basu R, Maulik M, Das Sarma J. Loss of Cx43-Mediated Functional Gap Junction Communication in Meningeal Fibroblasts Following Mouse Hepatitis Virus Infection. Mol Neurobiol. 2018 Aug; 55(8):6558-6571.

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Basu R, Bose A, Thomas D, Das Sarma J. Microtubule-assisted altered trafficking of astrocytic gap junction protein connexin 43 is associated with depletion of connexin 47 during mouse hepatitis virus infection. J Biol Chem. 2017 09 08; 292(36):14747-14763.

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