Receptors, Adrenergic, beta-2

"Receptors, Adrenergic, beta-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-2 receptors are more sensitive to EPINEPHRINE than to NOREPINEPHRINE and have a high affinity for the agonist TERBUTALINE. They are widespread, with clinically important roles in SKELETAL MUSCLE; LIVER; and vascular, bronchial, gastrointestinal, and genitourinary SMOOTH MUSCLE.

Descriptor ID	D018343
MeSH Number(s)	D12.776.543.750.670.300.300.340.200 D12.776.543.750.695.150.300.340.725 D12.776.543.750.720.330.300.340.200
Concept/Terms	Receptors, Adrenergic, beta-2 Receptors, Adrenergic, beta-2 beta 2 Adrenergic Receptors Receptor, Adrenergic, beta-2 Receptors, beta-2 Adrenergic Receptors, beta 2 Adrenergic Adrenergic beta-2 Receptors Adrenergic beta 2 Receptors Receptors, Adrenergic beta-2 beta-2 Receptors, Adrenergic Adrenergic Receptor, beta-2 Adrenergic Receptor, beta 2 Receptor, beta-2 Adrenergic beta-2 Adrenergic Receptor beta-2 Adrenergic Receptors Adrenergic Receptors, beta-2

Below are MeSH descriptors whose meaning is more general than "Receptors, Adrenergic, beta-2".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Biogenic Amine [D12.776.543.750.670]
Receptors, Catecholamine [D12.776.543.750.670.300]
Receptors, Adrenergic [D12.776.543.750.670.300.300]
Receptors, Adrenergic, beta [D12.776.543.750.670.300.300.340]
Receptors, Adrenergic, beta-2 [D12.776.543.750.670.300.300.340.200]
Receptors, G-Protein-Coupled [D12.776.543.750.695]
Receptors, Catecholamine [D12.776.543.750.695.150]
Receptors, Adrenergic [D12.776.543.750.695.150.300]
Receptors, Adrenergic, beta [D12.776.543.750.695.150.300.340]
Receptors, Adrenergic, beta-2 [D12.776.543.750.695.150.300.340.725]
Receptors, Neurotransmitter [D12.776.543.750.720]
Receptors, Catecholamine [D12.776.543.750.720.330]
Receptors, Adrenergic [D12.776.543.750.720.330.300]
Receptors, Adrenergic, beta [D12.776.543.750.720.330.300.340]
Receptors, Adrenergic, beta-2 [D12.776.543.750.720.330.300.340.200]

Below are MeSH descriptors whose meaning is related to "Receptors, Adrenergic, beta-2".

Below are MeSH descriptors whose meaning is more specific than "Receptors, Adrenergic, beta-2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, Adrenergic, beta-2" by people in this website by year, and whether "Receptors, Adrenergic, beta-2" was a major or minor topic of these publications.

Bar chart showing 69 publications over 28 distinct years, with a maximum of 6 publications in 1997

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
1996	3	1	4
1997	3	3	6
1998	5	0	5
1999	0	4	4
2000	1	1	2
2001	1	1	2
2002	3	1	4
2003	1	1	2
2004	3	1	4
2005	0	4	4
2006	0	1	1
2007	0	2	2
2008	1	1	2
2009	0	1	1
2010	1	2	3
2011	3	0	3
2012	1	1	2
2014	1	1	2
2015	2	1	3
2016	1	0	1
2017	1	0	1
2018	1	0	1
2021	1	0	1
2022	4	0	4
2023	1	1	2
2024	0	1	1
2025	0	1	1

Below are the most recent publications written about "Receptors, Adrenergic, beta-2" by people in Profiles.

Javed E, Nayak AP, Jannu AK, Cohen AH, Dewes I, Wang R, Tang DD, Deshpande DA, Penn RB. A-Kinase-Anchoring Protein Subtypes Differentially Regulate GPCR Signaling and Function in Human Airway Smooth Muscle. Am J Respir Cell Mol Biol. 2025 Feb; 72(2):133-144.

View in: PubMed
De Pascali F, Inoue A, Benovic JL. Diverse pathways in GPCR-mediated activation of Ca2+ mobilization in HEK293 cells. J Biol Chem. 2024 11; 300(11):107882.

View in: PubMed
Lefkowitz RJ, Rockman HA, Shim PJ, Liu S, Ahn S, Pani B, Rajagopal S, Shenoy SK, Bouvier M, Benovic JL, Liggett SB, Ruffolo RR, Bristow MR, Packer M. How carvedilol does not activate ?2-adrenoceptors. Nat Commun. 2023 11 30; 14(1):7866.

View in: PubMed
Ippolito M, De Pascali F, Hopfinger N, Komolov KE, Laurinavichyute D, Reddy PAN, Sakkal LA, Rajkowski KZ, Nayak AP, Lee J, Lee J, Cao G, Donover PS, Reichman M, An SS, Salvino JM, Penn RB, Armen RS, Scott CP, Benovic JL. Identification of a ?-arrestin-biased negative allosteric modulator for the ?2-adrenergic receptor. Proc Natl Acad Sci U S A. 2023 08; 120(31):e2302668120.

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Shah SD, Lind C, De Pascali F, Penn RB, MacKerell AD, Deshpande DA. In silico identification of a ?2-adrenoceptor allosteric site that selectively augments canonical ?2AR-Gs signaling and function. Proc Natl Acad Sci U S A. 2022 12 06; 119(49):e2214024119.

View in: PubMed
Deshpande DA, Penn RB. A cryptic mode of GPCR regulation revealed. Trends Mol Med. 2022 Nov; 28(11):900-901.

View in: PubMed
De Pascali F, Ippolito M, Wolfe E, Komolov KE, Hopfinger N, Lemenze D, Kim N, Armen RS, An SS, Scott CP, Benovic JL. ?2 -Adrenoceptor agonist profiling reveals biased signalling phenotypes for the ?2 -adrenoceptor with possible implications for the treatment of asthma. Br J Pharmacol. 2022 10; 179(19):4692-4708.

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Gardner KP, Cristofanilli M, Chumsri S, Lapidus R, Tang CM, Raghavakaimal A, Adams DL. Beta 2-Adrenergic Receptor in Circulating Cancer-Associated Cells Predicts for Increases in Stromal Macrophages in Circulation and Patient Survival in Metastatic Breast Cancer. Int J Mol Sci. 2022 Jun 30; 23(13).

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Ippolito M, De Pascali F, Inoue A, Benovic JL. Phenylalanine 193 in Extracellular Loop 2 of the ?2-Adrenergic Receptor Coordinates ?-Arrestin Interaction. Mol Pharmacol. 2022 02; 101(2):87-94.

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Grisanti LA, Thomas TP, Carter RL, de Lucia C, Gao E, Koch WJ, Benovic JL, Tilley DG. Pepducin-mediated cardioprotection via ?-arrestin-biased ?2-adrenergic receptor-specific signaling. Theranostics. 2018; 8(17):4664-4678.

View in: PubMed

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