Mice, Knockout

"Mice, Knockout" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

Descriptor ID	D018345
MeSH Number(s)	B01.050.050.136.500.500 B01.050.150.900.649.313.992.635.505.500.550.455 B01.050.150.900.649.313.992.635.505.500.800.500
Concept/Terms	Mice, Knockout Mice, Knockout Mice, Knock-out Knock-out Mice Mice, Knock out Mouse, Knockout Knockout Mouse Knockout Mice

Below are MeSH descriptors whose meaning is more general than "Mice, Knockout".

Organisms [B]
Eukaryota [B01]
Animals [B01.050]
Animal Population Groups [B01.050.050]
Animals, Genetically Modified [B01.050.050.136]
Mice, Transgenic [B01.050.050.136.500]
Mice, Knockout [B01.050.050.136.500.500]
Chordata [B01.050.150]
Vertebrates [B01.050.150.900]
Mammals [B01.050.150.900.649]
Eutheria [B01.050.150.900.649.313]
Rodentia [B01.050.150.900.649.313.992]
Muridae [B01.050.150.900.649.313.992.635]
Murinae [B01.050.150.900.649.313.992.635.505]
Mice [B01.050.150.900.649.313.992.635.505.500]
Mice, Mutant Strains [B01.050.150.900.649.313.992.635.505.500.550]
Mice, Knockout [B01.050.150.900.649.313.992.635.505.500.550.455]
Mice, Transgenic [B01.050.150.900.649.313.992.635.505.500.800]
Mice, Knockout [B01.050.150.900.649.313.992.635.505.500.800.500]

Below are MeSH descriptors whose meaning is related to "Mice, Knockout".

Below are MeSH descriptors whose meaning is more specific than "Mice, Knockout".

Mice, Knockout
Mice, Knockout, ApoE

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Mice, Knockout" by people in this website by year, and whether "Mice, Knockout" was a major or minor topic of these publications.

Bar chart showing 705 publications over 29 distinct years, with a maximum of 74 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1996	0	1	1
1997	0	3	3
1998	0	3	3
1999	0	6	6
2000	0	2	2
2001	0	8	8
2002	0	15	15
2003	0	26	26
2004	1	28	29
2005	0	41	41
2006	0	38	38
2007	0	54	54
2008	0	58	58
2009	0	54	54
2010	0	62	62
2011	1	73	74
2012	0	44	44
2013	0	15	15
2014	0	29	29
2015	0	29	29
2016	0	25	25
2017	0	20	20
2018	0	15	15
2019	0	9	9
2020	0	12	12
2021	0	20	20
2022	0	9	9
2023	0	3	3

Below are the most recent publications written about "Mice, Knockout" by people in Profiles.

Ma C, McCallen J, McVey JC, Trehan R, Bauer K, Zhang Q, Ruf B, Wang S, Lai CW, Trinchieri G, Berzofsky JA, Korangy F, Greten TF. CSF-1R+ Macrophages Control the Gut Microbiome-Enhanced Liver Invariant NKT Function through IL-18. J Immunol. 2023 10 01; 211(7):1099-1107.

View in: PubMed
Melo-Silva CR, Knudson CJ, Tang L, Kafle S, Springer LE, Choi J, Snyder CM, Wang Y, Kim SV, Sigal LJ. Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice. Cells. 2023 05 08; 12(9).

View in: PubMed
Tomar D, Thomas M, Garbincius JF, Kolmetzky DW, Salik O, Jadiya P, Joseph SK, Carpenter AC, Hajn?czky G, Elrod JW. MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca2+ uniporter channel. Sci Signal. 2023 04 25; 16(782):eabi8948.

View in: PubMed
Zhang W, Xiao D, Li X, Zhang Y, Rasouli J, Casella G, Boehm A, Hwang D, Ishikawa LL, Thome R, Ciric B, Curtis MT, Rostami A, Zhang GX. SIRT1 inactivation switches reactive astrocytes to an antiinflammatory phenotype in CNS autoimmunity. J Clin Invest. 2022 11 15; 132(22).

View in: PubMed
Nath PR, Pal-Nath D, Kaur S, Gangaplara A, Meyer TJ, Cam MC, Roberts DD. Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in mice. Oncoimmunology. 2022; 11(1):2111909.

View in: PubMed
Jengelley DHA, Wang M, Narasimhan A, Rupert JE, Young AR, Zhong X, Horan DJ, Robling AG, Koniaris LG, Zimmers TA. Exogenous Oncostatin M induces Cardiac Dysfunction, Musculoskeletal Atrophy, and Fibrosis. Cytokine. 2022 11; 159:155972.

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Pan X, Taherzadeh M, Bose P, Heon-Roberts R, Nguyen ALA, Xu T, Par? C, Yamanaka Y, Priestman DA, Platt FM, Khan S, Fnu N, Tomatsu S, Morales CR, Pshezhetsky AV. Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT. J Exp Med. 2022 08 01; 219(8).

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Lee N, Shi L, Colon Caraballo M, Nallasamy S, Mahendroo M, Iozzo RV, Myers K. Mechanical Response of Mouse Cervices Lacking Decorin and Biglycan During Pregnancy. J Biomech Eng. 2022 Jun 01; 144(6).

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Eckes T, Patyna S, Koch A, Oftring A, Gauer S, Oberm?ller N, Schwalm S, Schaefer L, Chun J, Gr?ne HJ, Pfeilschifter J. Sphingosine 1-Phosphate Receptor 5 (S1P5) Knockout Ameliorates Adenine-Induced Nephropathy. Int J Mol Sci. 2022 Apr 02; 23(7).

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Fahl SP, Sertori R, Zhang Y, Contreras AV, Harris B, Wang M, Perrigoue J, Balachandran S, Kennedy BK, Wiest DL. Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development without Affecting Protein Synthesis. J Immunol. 2022 02 15; 208(4):870-880.

View in: PubMed

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