"Replication Origin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A unique DNA sequence of a replicon at which DNA REPLICATION is initiated and proceeds bidirectionally or unidirectionally. It contains the sites where the first separation of the complementary strands occurs, a primer RNA is synthesized, and the switch from primer RNA to DNA synthesis takes place. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
| Descriptor ID |
D018741
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| MeSH Number(s) |
G05.360.340.024.220.760 G05.360.340.024.745.725
|
| Concept/Terms |
Replication Origin- Replication Origin
- Origin, Replication
- Origins, Replication
- ori Region
- Region, ori
- Regions, ori
- ori Regions
- Origin of Replication
- Replication Origins
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Below are MeSH descriptors whose meaning is more general than "Replication Origin".
Below are MeSH descriptors whose meaning is more specific than "Replication Origin".
This graph shows the total number of publications written about "Replication Origin" by people in this website by year, and whether "Replication Origin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 1 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "Replication Origin" by people in Profiles.
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Lee JH, Halgerson JS, Kim JH, O'Sullivan DJ. Comparative sequence analysis of plasmids from Lactobacillus delbrueckii and construction of a shuttle cloning vector. Appl Environ Microbiol. 2007 Jul; 73(14):4417-24.
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Iliakis G, Wang Y, Wang HY. Analysis of inhibition of DNA replication in irradiated cells using the SV40-based in vitro assay of DNA replication. Methods Mol Biol. 2006; 314:61-71.
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Bowers LM, Lapoint K, Anthony L, Pluciennik A, Filutowicz M. Bacterial expression system with tightly regulated gene expression and plasmid copy number. Gene. 2004 Sep 29; 340(1):11-8.
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Simmons DT, Gai D, Parsons R, Debes A, Roy R. Assembly of the replication initiation complex on SV40 origin DNA. Nucleic Acids Res. 2004; 32(3):1103-12.
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Jiao J, Simmons DT. Nonspecific double-stranded DNA binding activity of simian virus 40 large T antigen is involved in melting and unwinding of the origin. J Virol. 2003 Dec; 77(23):12720-8.
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Simmons DT, Roy R, Chen L, Gai D, Trowbridge PW. The activity of topoisomerase I is modulated by large T antigen during unwinding of the SV40 origin. J Biol Chem. 1998 Aug 7; 273(32):20390-6.
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Simmons DT, Trowbridge PW, Roy R. Topoisomerase I stimulates SV40 T antigen-mediated DNA replication and inhibits T antigen's ability to unwind DNA at nonorigin sites. Virology. 1998 Mar 15; 242(2):435-43.