"src Homology Domains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures. The SH1 domain is a CATALYTIC DOMAIN. SH2 and SH3 domains are protein interaction domains. SH2 usually binds PHOSPHOTYROSINE-containing proteins and SH3 interacts with CYTOSKELETAL PROTEINS.
| Descriptor ID |
D018909
|
| MeSH Number(s) |
G02.111.570.820.709.275.750.500.750
|
| Concept/Terms |
src Homology Domains- src Homology Domains
- Homology Domain, src
- Homology Domains, src
- src Homology Domain
- SH Domains
- SH Domain
SH2 Domain- SH2 Domain
- SH2 Domains
- src Homology Region 2 Domain
|
Below are MeSH descriptors whose meaning is more general than "src Homology Domains".
Below are MeSH descriptors whose meaning is more specific than "src Homology Domains".
This graph shows the total number of publications written about "src Homology Domains" by people in this website by year, and whether "src Homology Domains" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 1999 | 1 | 1 | 2 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "src Homology Domains" by people in Profiles.
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Evans BJ, Wang Z, Mobley L, Khosravi D, Fujii N, Navenot JM, Peiper SC. Physical association of GPR54 C-terminal with protein phosphatase 2A. Biochem Biophys Res Commun. 2008 Dec 26; 377(4):1067-71.
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Brachtel EF, Iafrate AJ, Mark EJ, Deshpande V. Cytomorphological correlates of epidermal growth factor receptor mutations in lung carcinoma. Diagn Cytopathol. 2007 May; 35(5):257-62.
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Ren SY, Bolton E, Mohi MG, Morrione A, Neel BG, Skorski T. Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences. Mol Cell Biol. 2005 Sep; 25(18):8001-8.
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Morgan JC, Majors JE, Galileo DS. Distinct and opposite roles for SH2 and SH3 domains of v-src in embryo survival and hemangiosarcoma formation. Clin Exp Metastasis. 2005; 22(2):167-75.
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Vecchione A, Marchese A, Henry P, Rotin D, Morrione A. The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. Mol Cell Biol. 2003 May; 23(9):3363-72.
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Chan TO, Rodeck U, Chan AM, Kimmelman AC, Rittenhouse SE, Panayotou G, Tsichlis PN. Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit. Cancer Cell. 2002 Mar; 1(2):181-91.
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Simpson A, Uitto J, Rodeck U, Mahoney MG. Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3. Gene. 2001 Jul 25; 273(1):29-39.
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Morgan JC, Majors JE, Galileo DS. Wild-type and mutant forms of v-src differentially alter neuronal migration and differentiation in vivo. J Neurosci Res. 2000 Jan 15; 59(2):226-37.
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Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C, Darnell JE. Stat3 as an oncogene. Cell. 1999 Aug 6; 98(3):295-303.
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Nieborowska-Skorska M, Wasik MA, Slupianek A, Salomoni P, Kitamura T, Calabretta B, Skorski T. Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis. J Exp Med. 1999 Apr 19; 189(8):1229-42.