"Cytochrome P-450 CYP2E1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.
| Descriptor ID |
D019392
|
| MeSH Number(s) |
D08.244.453.491.375 D08.811.682.662.582.338 D08.811.682.690.708.170.450.375 D12.776.422.220.453.491.375
|
| Concept/Terms |
Cytochrome P-450 CYP2E1- Cytochrome P-450 CYP2E1
- Cytochrome P 450 CYP2E1
- Cytochrome P-450-J
- Cytochrome P 450 J
- 4-Nitrophenol-2-Hydroxylase
- 4 Nitrophenol 2 Hydroxylase
- Dimethylnitrosamine N-Demethylase
- Dimethylnitrosamine N Demethylase
- Cytochrome P450 2E1
- N-Nitrosodimethylamine Demethylase
- N Nitrosodimethylamine Demethylase
- CYP 2E1
- Cytochrome P-450 IIE1
- Cytochrome P 450 IIE1
- CYP IIE1
- CYPIIE1
- Cytochrome P-450 (ALC)
- CYP2E1
|
Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP2E1".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 CYP2E1".
This graph shows the total number of publications written about "Cytochrome P-450 CYP2E1" by people in this website by year, and whether "Cytochrome P-450 CYP2E1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cytochrome P-450 CYP2E1" by people in Profiles.
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Davydov DR, Davydova NY, Rodgers JT, Rushmore TH, Jones JP. Toward a systems approach to the human cytochrome P450 ensemble: interactions between CYP2D6 and CYP2E1 and their functional consequences. Biochem J. 2017 10 10; 474(20):3523-3542.
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Asadi-Pooya AA, Mintzer S, Sperling MR. Nutritional supplements, foods, and epilepsy: is there a relationship? Epilepsia. 2008 Nov; 49(11):1819-27.
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Choi JY, Abel J, Neuhaus T, Ko Y, Harth V, Hamajima N, Tajima K, Yoo KY, Park SK, Noh DY, Han W, Choe KJ, Ahn SH, Kim SU, Hirvonen A, Kang D. Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development. Pharmacogenetics. 2003 Feb; 13(2):67-72.
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Shayiq RM, Roberts DW, Rothstein K, Snawder JE, Benson W, Ma X, Black M. Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen-induced lethality in mice: an explanation for high acetaminophen dosage in humans without hepatic injury. Hepatology. 1999 Feb; 29(2):451-63.
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Israel Y. Antibodies against ethanol-derived protein adducts: pathogenic implications. Gastroenterology. 1997 Jul; 113(1):353-5.
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Clot P, Albano E, Eliasson E, Tabone M, Aric? S, Israel Y, Moncada C, Ingelman-Sundberg M. Cytochrome P4502E1 hydroxyethyl radical adducts as the major antigen in autoantibody formation among alcoholics. Gastroenterology. 1996 Jul; 111(1):206-16.
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Ross AD, Varghese G, Oporto B, Carmichael FJ, Israel Y. Effect of propylthiouracil treatment on NADPH-cytochrome P450 reductase levels, oxygen consumption and hydroxyl radical formation in liver microsomes from rats fed ethanol or acetone chronically. Biochem Pharmacol. 1995 Mar 30; 49(7):979-89.