"Disintegrins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.
| Descriptor ID |
D019483
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| MeSH Number(s) |
D12.644.138
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Disintegrins".
Below are MeSH descriptors whose meaning is more specific than "Disintegrins".
This graph shows the total number of publications written about "Disintegrins" by people in this website by year, and whether "Disintegrins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 1 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 2 | 0 | 2 |
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Below are the most recent publications written about "Disintegrins" by people in Profiles.
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McLane MA, Joerger T, Mahmoud A. Disintegrins in health and disease. Front Biosci. 2008; 13:6617-37.
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Galán JA, Sánchez EE, Rodríguez-Acosta A, Soto JG, Bashir S, McLane MA, Paquette-Straub C, Pérez JC. Inhibition of lung tumor colonization and cell migration with the disintegrin crotatroxin 2 isolated from the venom of Crotalus atrox. Toxicon. 2008 Jun 1; 51(7):1186-96.
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McLane MA, Paquette-Straub C. Scientific and standardization committee communications: classification and nomenclature of disintegrins isolated from snake venoms. J Thromb Haemost. 2007 Sep; 5(9):1971.
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Butera D, Piazza RM, McLane MA, Chammas R, da Silva AM. Molecular engineering of an EGFP/disintegrin-based integrin marker. Toxicon. 2005 Aug; 46(2):178-84.
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McLane MA, Zhang X, Tian J, Zelinskas C, Srivastava A, Hensley B, Paquette-Straub C. Scratching below the surface: wound healing and alanine mutagenesis provide unique insights into interactions between eristostatin, platelets and melanoma cells. Pathophysiol Haemost Thromb. 2005; 34(4-5):164-8.
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McLane MA, Sanchez EE, Wong A, Paquette-Straub C, Perez JC. Disintegrins. Curr Drug Targets Cardiovasc Haematol Disord. 2004 Dec; 4(4):327-55.
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Kisiel DG, Calvete JJ, Katzhendler J, Fertala A, Lazarovici P, Marcinkiewicz C. Structural determinants of the selectivity of KTS-disintegrins for the alpha1beta1 integrin. FEBS Lett. 2004 Nov 19; 577(3):478-82.
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Butera D, Skielka K, McLane MA, Paquette-Straub C, Ducancel F, da Silva AM. Cloning, expression, and characterization of a bi-functional disintegrin/alkaline phosphatase hybrid protein. Protein Expr Purif. 2003 Oct; 31(2):286-91.
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McLane MA, Kuchar MA, Brando C, Santoli D, Paquette-Straub CA, Miele ME. New insights on disintegrin-receptor interactions: eristostatin and melanoma cells. Haemostasis. 2001 May-Dec; 31(3-6):177-82.