"Guanidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
| Descriptor ID |
D019791
|
| MeSH Number(s) |
D02.078.370.472
|
| Concept/Terms |
Guanidine Hydrochloride- Guanidine Hydrochloride
- Hydrochloride, Guanidine
- Guanidinium Chloride
- Chloride, Guanidinium
- Guanidium Chloride
- Chloride, Guanidium
- Guanidine Monohydrochloride
- Monohydrochloride, Guanidine
|
Below are MeSH descriptors whose meaning is more general than "Guanidine".
Below are MeSH descriptors whose meaning is more specific than "Guanidine".
This graph shows the total number of publications written about "Guanidine" by people in this website by year, and whether "Guanidine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Guanidine" by people in Profiles.
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Busacca CA, Milligan JA, Rattanangkool E, Ramavarapu C, Chen A, Saha AK, Li Z, Lee H, Geib SJ, Wang G, Senanayake CH, Wipf P. Synthesis of phosphaguanidines by hydrophosphination of carbodiimides with phosphine boranes. J Org Chem. 2014 Oct 17; 79(20):9878-87.
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Bhardwaj A, Walker-Kopp N, Wilkens S, Cingolani G. Foldon-guided self-assembly of ultra-stable protein fibers. Protein Sci. 2008 Sep; 17(9):1475-85.
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Bhardwaj A, Olia AS, Walker-Kopp N, Cingolani G. Domain organization and polarity of tail needle GP26 in the portal vertex structure of bacteriophage P22. J Mol Biol. 2007 Aug 10; 371(2):374-87.
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Powers SL, Robinson CR, Robinson AS. Denaturation of an extremely stable hyperthermophilic protein occurs via a dimeric intermediate. Extremophiles. 2007 Jan; 11(1):179-89.
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Swift J, Wehbi WA, Kelly BD, Stowell XF, Saven JG, Dmochowski IJ. Design of functional ferritin-like proteins with hydrophobic cavities. J Am Chem Soc. 2006 May 24; 128(20):6611-9.
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Videla LA, Tapia G, Varela P, Cornejo P, Guerrero J, Israel Y, Fern?ndez V. Effects of acute gamma-hexachlorocyclohexane intoxication in relation to the redox regulation of nuclear factor-kappaB, cytokine gene expression, and liver injury in the rat. Antioxid Redox Signal. 2004 Apr; 6(2):471-80.
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Goldoni S, Owens RT, McQuillan DJ, Shriver Z, Sasisekharan R, Birk DE, Campbell S, Iozzo RV. Biologically active decorin is a monomer in solution. J Biol Chem. 2004 Feb 20; 279(8):6606-12.
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Pitari G, D'Archivio AA, Di Leandro L, Antonini G, Panatta A, Tettamanti E, Dupr? S, Malatesta F. Conformational changes at the active site of pantetheine hydrolase during denaturation by guanidine hydrochloride. J Protein Chem. 1999 Oct; 18(7):785-9.
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Pitari G, Antonini G, Mancini R, Dupr? S. Thermal resistance of pantetheine hydrolase. Biochim Biophys Acta. 1996 Nov 14; 1298(1):31-6.