Nuclear Localization Signals
"Nuclear Localization Signals" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Short, predominantly basic amino acid sequences identified as nuclear import signals for some proteins. These sequences are believed to interact with specific receptors at the NUCLEAR PORE.
| Descriptor ID |
D019913
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| MeSH Number(s) |
D12.644.770.610 G02.111.570.060.670.610
|
| Concept/Terms |
Nuclear Localization Signals- Nuclear Localization Signals
- Nuclear Localization Signal Peptide
- Nuclear Localization Signal
- Signal, Nuclear Localization
- Signals, Nuclear Localization
- NLS Peptide
- NLS Peptides
- Peptide, NLS
- Peptides, NLS
|
Below are MeSH descriptors whose meaning is more general than "Nuclear Localization Signals".
Below are MeSH descriptors whose meaning is more specific than "Nuclear Localization Signals".
This graph shows the total number of publications written about "Nuclear Localization Signals" by people in this website by year, and whether "Nuclear Localization Signals" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 3 | 3 |
| 2011 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2022 | 1 | 1 | 2 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Nuclear Localization Signals" by people in Profiles.
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Hayashi M, Girdhar A, Ko YH, Kim KM, DePierro JA, Buchler JR, Arunprakash N, Bajaj A, Cingolani G, Guo L. Engineered NLS-chimera downregulates expression of aggregation-prone endogenous FUS. Nat Commun. 2024 Sep 10; 15(1):7887.
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Doll SG, Meshkin H, Bryer AJ, Li F, Ko YH, Lokareddy RK, Gillilan RE, Gupta K, Perilla JR, Cingolani G. Recognition of the TDP-43 nuclear localization signal by importin a1/ß. Cell Rep. 2022 Jun 28; 39(13):111007.
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Florio TJ, Lokareddy RK, Yeggoni DP, Sankhala RS, Ott CA, Gillilan RE, Cingolani G. Differential recognition of canonical NF-?B dimers by Importin a3. Nat Commun. 2022 03 08; 13(1):1207.
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Malaguarnera L, Nunnari G, Di Rosa M. Nuclear import sequence identification in hOAS3 protein. Inflamm Res. 2016 Nov; 65(11):895-904.
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Lott K, Bhardwaj A, Sims PJ, Cingolani G. A minimal nuclear localization signal (NLS) in human phospholipid scramblase 4 that binds only the minor NLS-binding site of importin alpha1. J Biol Chem. 2011 Aug 12; 286(32):28160-9.
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Lott K, Cingolani G. The importin ß binding domain as a master regulator of nucleocytoplasmic transport. Biochim Biophys Acta. 2011 Sep; 1813(9):1578-92.
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Rodríguez E, Aburjania N, Priedigkeit NM, DiFeo A, Martignetti JA. Nucleo-cytoplasmic localization domains regulate Krüppel-like factor 6 (KLF6) protein stability and tumor suppressor function. PLoS One. 2010 Sep 09; 5(9).
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Nardozzi J, Wenta N, Yasuhara N, Vinkemeier U, Cingolani G. Molecular basis for the recognition of phosphorylated STAT1 by importin alpha5. J Mol Biol. 2010 Sep 10; 402(1):83-100.
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Montie HL, Cho MS, Holder L, Liu Y, Tsvetkov AS, Finkbeiner S, Merry DE. Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy. Hum Mol Genet. 2009 Jun 1; 18(11):1937-50.
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Roman-Blas JA, Jimenez SA. Targeting NF-kappaB: a promising molecular therapy in inflammatory arthritis. Int Rev Immunol. 2008; 27(5):351-74.