Activated Protein C Resistance
"Activated Protein C Resistance" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.
| Descriptor ID |
D020016
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| MeSH Number(s) |
C15.378.100.100.037 C15.378.100.141.036 C15.378.925.050 C16.320.099.037
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Activated Protein C Resistance".
Below are MeSH descriptors whose meaning is more specific than "Activated Protein C Resistance".
This graph shows the total number of publications written about "Activated Protein C Resistance" by people in this website by year, and whether "Activated Protein C Resistance" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 1 | 0 | 1 |
| 2000 | 3 | 0 | 3 |
| 2005 | 0 | 1 | 1 |
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Below are the most recent publications written about "Activated Protein C Resistance" by people in Profiles.
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Jennings I, Kitchen S, Woods TA, Preston FE. Multilaboratory testing in thrombophilia through the United Kingdom National External Quality Assessment Scheme (Blood Coagulation) Quality Assurance Program. Semin Thromb Hemost. 2005 Feb; 31(1):66-72.
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Major DA, Sane DC, Herrington DM. Cardiovascular implications of the factor V Leiden mutation. Am Heart J. 2000 Aug; 140(2):189-95.
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Santacroce R, Bossone A, Brancaccio V, Fortina P, Margaglione M. In the presence of other inherited or acquired high-risk situations, the FV Cambridge mutation may be an additional thrombophilic risk factor, through its effect on APC sensitivity. Thromb Haemost. 2000 Jun; 83(6):963-4.
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Jennings I, Kitchen S, Cooper PC, Rimmer JE, Woods TA, Preston FE. Further evidence that activated protein C resistance affects protein C coagulant activity assays. Thromb Haemost. 2000 Jan; 83(1):171-2.
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Tayyanipour R, Pulido JS, Postel EA, Lipkowitz JL, Pisciotta A, Braza E. Arterial vascular occlusion associated with factor V Leiden gene mutation. Retina. 1998; 18(4):376-7.
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Arkel YS, Ku D, Kamiyama M, Pajaro R, Alder H, Marchand A. A highly specific functional test for factor V leiden: A modified tissue factor assay for activated protein C resistance. Haemostasis. 1997 Nov-Dec; 27(6):290-304.