"Immunophilins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
| Descriptor ID |
D020104
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| MeSH Number(s) |
D08.811.399.325.500.400 D12.776.543.750.705.400 D12.776.827.275
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Immunophilins".
Below are MeSH descriptors whose meaning is more specific than "Immunophilins".
This graph shows the total number of publications written about "Immunophilins" by people in this website by year, and whether "Immunophilins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
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Below are the most recent publications written about "Immunophilins" by people in Profiles.
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Patterson CE, Abrams WR, Wolter NE, Rosenbloom J, Davis EC. Developmental regulation and coordinate reexpression of FKBP65 with extracellular matrix proteins after lung injury suggest a specialized function for this endoplasmic reticulum immunophilin. Cell Stress Chaperones. 2005; 10(4):285-95.
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Steplewski A, Ebel W, Planey SL, Alnemri ES, Robertson NM, Litwack G. Phosphorylation of the insect immunophilin FKBP46 by the Spodoptera frugiperda homolog of casein kinase II. Gene. 2000 Apr 4; 246(1-2):169-78.