A biosensing technique in which biomolecules capable of binding to specific analytes or ligands are first immobilized on one side of a metallic film. Light is then focused on the opposite side of the film to excite the surface plasmons, that is, the oscillations of free electrons propagating along the film's surface. The refractive index of light reflecting off this surface is measured. When the immobilized biomolecules are bound by their ligands, an alteration in surface plasmons on the opposite side of the film is created which is directly proportional to the change in bound, or adsorbed, mass. Binding is measured by changes in the refractive index. The technique is used to study biomolecular interactions, such as antigen-antibody binding.

Descriptor ID	D020349
MeSH Number(s)	E05.196.890 E05.601.043.700
Concept/Terms	Surface Plasmon Resonance Surface Plasmon Resonance Plasmon Resonance, Surface Plasmon Resonances, Surface Resonance, Surface Plasmon Resonances, Surface Plasmon Surface Plasmon Resonances

Below are MeSH descriptors whose meaning is more general than "Surface Plasmon Resonance".

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Below are MeSH descriptors whose meaning is more specific than "Surface Plasmon Resonance".