Calcium Channels, L-Type

"Calcium Channels, L-Type" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.

Descriptor ID	D020746
MeSH Number(s)	D12.776.157.530.400.150.400 D12.776.543.550.450.150.400 D12.776.543.585.400.150.400
Concept/Terms	Calcium Channels, L-Type Calcium Channels, L-Type Calcium Channels, L Type L-Type VDCC L Type VDCC VDCC, L-Type L-Type Calcium Channel Calcium Channel, L-Type L Type Calcium Channel L-Type Voltage-Dependent Calcium Channels L Type Voltage Dependent Calcium Channels L-Type Calcium Channels L Type Calcium Channels Long-Lasting Calcium Channels Calcium Channels, Long-Lasting Long Lasting Calcium Channels Receptors, Dihydropyridine Receptors, Dihydropyridine L-Type VDCC alpha-1 Subunit L Type VDCC alpha 1 Subunit Dihydropyridine Receptor Receptor, Dihydropyridine Dihydropyridine Receptors L-Type VDCC delta Subunit L-Type VDCC delta Subunit L Type VDCC delta Subunit L-Type VDCC alpha-2 Subunit L-Type VDCC alpha-2 Subunit L Type VDCC alpha 2 Subunit L-Type VDCC beta Subunit L-Type VDCC beta Subunit L Type VDCC beta Subunit L-Type VDCC gamma Subunit L-Type VDCC gamma Subunit L Type VDCC gamma Subunit

Below are MeSH descriptors whose meaning is more general than "Calcium Channels, L-Type".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Channels [D12.776.157.530.400]
Calcium Channels [D12.776.157.530.400.150]
Calcium Channels, L-Type [D12.776.157.530.400.150.400]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Ion Channels [D12.776.543.550.450]
Calcium Channels [D12.776.543.550.450.150]
Calcium Channels, L-Type [D12.776.543.550.450.150.400]
Membrane Transport Proteins [D12.776.543.585]
Ion Channels [D12.776.543.585.400]
Calcium Channels [D12.776.543.585.400.150]
Calcium Channels, L-Type [D12.776.543.585.400.150.400]

Below are MeSH descriptors whose meaning is related to "Calcium Channels, L-Type".

Below are MeSH descriptors whose meaning is more specific than "Calcium Channels, L-Type".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Calcium Channels, L-Type" by people in this website by year, and whether "Calcium Channels, L-Type" was a major or minor topic of these publications.

Bar chart showing 22 publications over 11 distinct years, with a maximum of 3 publications in 2004 and 2005 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	2	0	2
2004	2	1	3
2005	3	0	3
2006	1	0	1
2007	2	0	2
2008	1	1	2
2009	1	1	2
2010	2	1	3
2011	1	1	2
2014	0	1	1
2018	0	1	1

Below are the most recent publications written about "Calcium Channels, L-Type" by people in Profiles.

Brailoiu E, Barlow CL, Ramirez SH, Abood ME, Brailoiu GC. Effects of Platelet-Activating Factor on Brain Microvascular Endothelial Cells. Neuroscience. 2018 05 01; 377:105-113.

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Shu J, Li Y, Ju R, Yan GX. Two types of T wave alternans in long-QT syndrome. J Cardiovasc Electrophysiol. 2014 Aug; 25(8):910-912.

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Song J, Gao E, Wang J, Zhang XQ, Chan TO, Koch WJ, Shang X, Joseph JI, Peterson BZ, Feldman AM, Cheung JY. Constitutive overexpression of phosphomimetic phospholemman S68E mutant results in arrhythmias, early mortality, and heart failure: potential involvement of Na+/Ca2+ exchanger. Am J Physiol Heart Circ Physiol. 2012 Feb 1; 302(3):H770-81.

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Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, Jin ZG. Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1. Circ Res. 2012 Jan 6; 110(1):59-70.

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Völkers M, Weidenhammer C, Herzog N, Qiu G, Spaich K, von Wegner F, Peppel K, Müller OJ, Schinkel S, Rabinowitz JE, Hippe HJ, Brinks H, Katus HA, Koch WJ, Eckhart AD, Friedrich O, Most P. The inotropic peptide ßARKct improves ßAR responsiveness in normal and failing cardiomyocytes through G(ß?)-mediated L-type calcium current disinhibition. Circ Res. 2011 Jan 7; 108(1):27-39.

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Oca P, Zaka R, Dion AS, Freeman TA, Williams CJ. Phosphate and calcium are required for TGFbeta-mediated stimulation of ANK expression and function during chondrogenesis. J Cell Physiol. 2010 Aug; 224(2):540-8.

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Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S. Role of Ca(2+)/calmodulin-dependent protein kinase II in the regulation of the cardiac L-type Ca(2+) current during endothelin-1 stimulation. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H1902-7.

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Wang J, Chan TO, Zhang XQ, Gao E, Song J, Koch WJ, Feldman AM, Cheung JY. Induced overexpression of Na+/Ca2+ exchanger transgene: altered myocyte contractility, [Ca2+]i transients, SR Ca2+ contents, and action potential duration. Am J Physiol Heart Circ Physiol. 2009 Aug; 297(2):H590-601.

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Shao Y, Czymmek KJ, Jones PA, Fomin VP, Akanbi K, Duncan RL, Farach-Carson MC. Dynamic interactions between L-type voltage-sensitive calcium channel Cav1.2 subunits and ahnak in osteoblastic cells. Am J Physiol Cell Physiol. 2009 May; 296(5):C1067-78.

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Medei EH, Nascimento JH, Pedrosa RC, Barcellos L, Masuda MO, Sicouri S, Elizari MV, de Carvalho AC. Antibodies with beta-adrenergic activity from chronic chagasic patients modulate the QT interval and M cell action potential duration. Europace. 2008 Jul; 10(7):868-76.

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