"Focal Adhesions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An anchoring junction of the cell to a non-cellular substrate. It is composed of a specialized area of the plasma membrane where bundles of the ACTIN CYTOSKELETON terminate and attach to the transmembrane linkers, INTEGRINS, which in turn attach through their extracellular domains to EXTRACELLULAR MATRIX PROTEINS.
| Descriptor ID |
D022001
|
| MeSH Number(s) |
A11.284.149.165.165.285
|
| Concept/Terms |
Focal Adhesions- Focal Adhesions
- Adhesion, Focal
- Adhesions, Focal
- Focal Adhesion
- Focal Contacts
- Contact, Focal
- Contacts, Focal
- Focal Contact
- Adhesion Plaques
- Adhesion Plaque
- Plaque, Adhesion
- Plaques, Adhesion
- Cell-Matrix Adherens Junctions
- Adherens Junction, Cell-Matrix
- Adherens Junctions, Cell-Matrix
- Cell Matrix Adherens Junctions
- Cell-Matrix Adherens Junction
- Junction, Cell-Matrix Adherens
- Junctions, Cell-Matrix Adherens
|
Below are MeSH descriptors whose meaning is more general than "Focal Adhesions".
Below are MeSH descriptors whose meaning is more specific than "Focal Adhesions".
This graph shows the total number of publications written about "Focal Adhesions" by people in this website by year, and whether "Focal Adhesions" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 1 | 2 |
| 2006 | 0 | 2 | 2 |
| 2007 | 3 | 0 | 3 |
| 2008 | 1 | 3 | 4 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 2 | 3 |
| 2012 | 1 | 1 | 2 |
| 2014 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Focal Adhesions" by people in Profiles.
-
Cocom-Chan B, Khakzad H, Konate M, Aguilar DI, Bello C, Valencia-Gallardo C, Zarrouk Y, Fattaccioli J, Mauviel A, Javelaud D, Tran Van Nhieu G. IpaA reveals distinct modes of vinculin activation during Shigella invasion and cell-matrix adhesion. Life Sci Alliance. 2024 Aug; 7(8).
-
Chan GK, McGrath JA, Parsons M. Spatial activation of ezrin by epidermal growth factor receptor and focal adhesion kinase co-ordinates epithelial cell migration. Open Biol. 2021 08; 11(8):210166.
-
Haller JA, Stalmans P, Benz MS, Gandorfer A, Pakola SJ, Girach A, Kampik A, Jaffe GJ, Toth CA. Efficacy of intravitreal ocriplasmin for treatment of vitreomacular adhesion: subgroup analyses from two randomized trials. Ophthalmology. 2015 Jan; 122(1):117-22.
-
Menko AS, Bleaken BM, Libowitz AA, Zhang L, Stepp MA, Walker JL. A central role for vimentin in regulating repair function during healing of the lens epithelium. Mol Biol Cell. 2014 Mar; 25(6):776-90.
-
Seqqat R, Guo X, Rafiq K, Kolpakov MA, Guo J, Koch WJ, Houser SR, Dell'italia LJ, Sabri A. Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload. J Mol Cell Cardiol. 2012 Aug; 53(2):240-9.
-
Kacena MA, Eleniste PP, Cheng YH, Huang S, Shivanna M, Meijome TE, Mayo LD, Bruzzaniti A. Megakaryocytes regulate expression of Pyk2 isoforms and caspase-mediated cleavage of actin in osteoblasts. J Biol Chem. 2012 May 18; 287(21):17257-17268.
-
Rafiq K, Guo J, Vlasenko L, Guo X, Kolpakov MA, Sanjay A, Houser SR, Sabri A. c-Cbl ubiquitin ligase regulates focal adhesion protein turnover and myofibril degeneration induced by neutrophil protease cathepsin G. J Biol Chem. 2012 Feb 17; 287(8):5327-39.
-
Naik MU, Naik UP. Contra-regulation of calcium- and integrin-binding protein 1-induced cell migration on fibronectin by PAK1 and MAP kinase signaling. J Cell Biochem. 2011 Nov; 112(11):3289-99.
-
Krishna OD, Jha AK, Jia X, Kiick KL. Integrin-mediated adhesion and proliferation of human MSCs elicited by a hydroxyproline-lacking, collagen-like peptide. Biomaterials. 2011 Sep; 32(27):6412-24.
-
Liu S, Xu SW, Blumbach K, Eastwood M, Denton CP, Eckes B, Krieg T, Abraham DJ, Leask A. Expression of integrin beta1 by fibroblasts is required for tissue repair in vivo. J Cell Sci. 2010 Nov 1; 123(Pt 21):3674-82.