Neurofibromin 1

"Neurofibromin 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A protein found most abundantly in the nervous system. Defects or deficiencies in this protein are associated with NEUROFIBROMATOSIS 1, Watson syndrome, and LEOPARD syndrome. Mutations in the gene (GENE, NEUROFIBROMATOSIS 1) affect two known functions: regulation of ras-GTPase and tumor suppression.

Descriptor ID	D025542
MeSH Number(s)	D12.644.360.325.150.500.460 D12.776.476.325.150.500.460 D12.776.624.776.610
Concept/Terms	Neurofibromin 1 Neurofibromin 1 Neurofibromatosis Type 1 Protein NF1-GAP-Related Protein NF1 GAP Related Protein NF-1 Protein NF 1 Protein NF1 GRP NF1 Protein Neurofibromin Neurofibromatosis Type 1 Gene Product

Below are MeSH descriptors whose meaning is more general than "Neurofibromin 1".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
GTP-Binding Protein Regulators [D12.644.360.325]
GTPase-Activating Proteins [D12.644.360.325.150]
ras GTPase-Activating Proteins [D12.644.360.325.150.500]
Neurofibromin 1 [D12.644.360.325.150.500.460]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
GTP-Binding Protein Regulators [D12.776.476.325]
GTPase-Activating Proteins [D12.776.476.325.150]
ras GTPase-Activating Proteins [D12.776.476.325.150.500]
Neurofibromin 1 [D12.776.476.325.150.500.460]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
Neurofibromin 1 [D12.776.624.776.610]

Below are MeSH descriptors whose meaning is more specific than "Neurofibromin 1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Neurofibromin 1" by people in this website by year, and whether "Neurofibromin 1" was a major or minor topic of these publications.

Bar chart showing 8 publications over 7 distinct years, with a maximum of 2 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	1	0	1
2005	0	2	2
2006	1	0	1
2009	0	1	1
2013	1	0	1
2019	1	0	1
2020	1	0	1

Below are the most recent publications written about "Neurofibromin 1" by people in Profiles.

Elmadany N, Logiacco F, Buonfiglioli A, Haage VC, Wright-Jin EC, Schattenberg A, Papawassiliou RM, Kettenmann H, Semtner M, Gutmann DH. Neurofibromatosis 1 - Mutant microglia exhibit sexually-dimorphic cyclic AMP-dependent purinergic defects. Neurobiol Dis. 2020 10; 144:105030.

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Rybinski B, Wolinsky T, Brohl A, Moerdler S, Reed DR, Ewart M, Weiser D. Multifocal primary neuroblastoma tumor heterogeneity in siblings with co-occurring PHOX2B and NF1 genetic aberrations. Genes Chromosomes Cancer. 2020 02; 59(2):119-124.

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Stewart DR, Brems H, Gomes AG, Ruppert SL, Callens T, Williams J, Claes K, Bober MB, Hachen R, Kaban LB, Li H, Lin A, McDonald M, Melancon S, Ortenberg J, Radtke HB, Samson I, Saul RA, Shen J, Siqveland E, Toler TL, van Maarle M, Wallace M, Williams M, Legius E, Messiaen L. Jaffe-Campanacci syndrome, revisited: detailed clinical and molecular analyses determine whether patients have neurofibromatosis type 1, coincidental manifestations, or a distinct disorder. Genet Med. 2014 Jun; 16(6):448-59.

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Williams VC, Lucas J, Babcock MA, Gutmann DH, Korf B, Maria BL. Neurofibromatosis type 1 revisited. Pediatrics. 2009 Jan; 123(1):124-33.

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Schirinzi A, Drmanac S, Dallapiccola B, Huang S, Scott K, De Luca A, Swanson D, Drmanac R, Surrey S, Fortina P. Combinatorial sequencing-by-hybridization: analysis of the NF1 gene. Genet Test. 2006; 10(1):8-17.

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Iijima-Ando K, Yin JC. Transgenic cAMP response element reporter flies for monitoring circadian rhythms. Methods Enzymol. 2005; 393:302-15.

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Laskin WB, Fetsch JF, Lasota J, Miettinen M. Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases. Am J Surg Pathol. 2005 Jan; 29(1):39-51.

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Lasota J, Wasag B, Dansonka-Mieszkowska A, Karcz D, Millward CL, Rys J, Stachura J, Sobin LH, Miettinen M. Evaluation of NF2 and NF1 tumor suppressor genes in distinctive gastrointestinal nerve sheath tumors traditionally diagnosed as benign schwannomas: s study of 20 cases. Lab Invest. 2003 Sep; 83(9):1361-71.

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