Adenomatous Polyposis Coli Protein

"Adenomatous Polyposis Coli Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A negative regulator of beta-catenin signaling which is mutant in ADENOMATOUS POLYPOSIS COLI and GARDNER SYNDROME.

Descriptor ID	D025601
MeSH Number(s)	D05.500.117.249 D12.776.220.040 D12.776.476.081.249 D12.776.624.776.010
Concept/Terms	Adenomatous Polyposis Coli Protein Adenomatous Polyposis Coli Protein

Below are MeSH descriptors whose meaning is more general than "Adenomatous Polyposis Coli Protein".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Multiprotein Complexes [D05.500]
Axin Signaling Complex [D05.500.117]
Adenomatous Polyposis Coli Protein [D05.500.117.249]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Cytoskeletal Proteins [D12.776.220]
Adenomatous Polyposis Coli Protein [D12.776.220.040]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Axin Signaling Complex [D12.776.476.081]
Adenomatous Polyposis Coli Protein [D12.776.476.081.249]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
Adenomatous Polyposis Coli Protein [D12.776.624.776.010]

Below are MeSH descriptors whose meaning is related to "Adenomatous Polyposis Coli Protein".

Below are MeSH descriptors whose meaning is more specific than "Adenomatous Polyposis Coli Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Adenomatous Polyposis Coli Protein" by people in this website by year, and whether "Adenomatous Polyposis Coli Protein" was a major or minor topic of these publications.

Bar chart showing 13 publications over 12 distinct years, with a maximum of 2 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	0	1
2004	1	0	1
2005	1	0	1
2008	0	1	1
2009	1	0	1
2010	1	0	1
2011	2	0	2
2013	1	0	1
2016	0	1	1
2017	1	0	1
2018	1	0	1
2020	0	1	1

Below are the most recent publications written about "Adenomatous Polyposis Coli Protein" by people in Profiles.

Clapper ML, Chang WL, Cooper HS. Dysplastic Aberrant Crypt Foci: Biomarkers of Early Colorectal Neoplasia and Response to Preventive Intervention. Cancer Prev Res (Phila). 2020 03; 13(3):229-240.

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Emerick B, Schleiniger G, Boman BM. Multi-scale modeling of APC and [Formula: see text]-catenin regulation in the human colonic crypt. J Math Biol. 2018 Jun; 76(7):1797-1830.

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Emerick B, Schleiniger G, Boman BM. A kinetic model to study the regulation of ?-catenin, APC, and Axin in the human colonic crypt. J Math Biol. 2017 11; 75(5):1171-1202.

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Chae YK, Davis AA, Carneiro BA, Chandra S, Mohindra N, Kalyan A, Kaplan J, Matsangou M, Pai S, Costa R, Jovanovic B, Cristofanilli M, Platanias LC, Giles FJ. Concordance between genomic alterations assessed by next-generation sequencing in tumor tissue or circulating cell-free DNA. Oncotarget. 2016 Oct 04; 7(40):65364-65373.

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Hamilton KE, Noubissi FK, Katti PS, Hahn CM, Davey SR, Lundsmith ET, Klein-Szanto AJ, Rhim AD, Spiegelman VS, Rustgi AK. IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts. Carcinogenesis. 2013 Nov; 34(11):2647-54.

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Trufant J, Kurz W, Frankel A, Muthusamy V, McKinnon W, Greenblatt M, Lazar A, Cook D, Bosenberg M. Familial multiple pilomatrixomas as a presentation of attenuated adenomatosis polyposis coli. J Cutan Pathol. 2012 Apr; 39(4):440-3.

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Crist RC, Roth JJ, Lisanti MP, Siracusa LD, Buchberg AM. Identification of Mom12 and Mom13, two novel modifier loci of Apc (Min) -mediated intestinal tumorigenesis. Cell Cycle. 2011 Apr 1; 10(7):1092-9.

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Crist RC, Roth JJ, Baran AA, McEntee BJ, Siracusa LD, Buchberg AM. The armadillo repeat domain of Apc suppresses intestinal tumorigenesis. Mamm Genome. 2010 Oct; 21(9-10):450-7.

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Boman B, Kopelovich L, Siracusa LD, Zhang T, Henderson K, Cofer Z, Buchberg AM, Fields JZ, Otevrel T. A Tcf4-GFP reporter mouse model for monitoring effects of Apc mutations during intestinal tumorigenesis. Mol Carcinog. 2009 Sep; 48(9):821-31.

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Li P, Schulz S, Pitari GM, Waldman SA. Sex modulates intestinal transformation by the tumor-suppressor GCC. Clin Transl Sci. 2008 Sep; 1(2):146-50.

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