RNA, Small Interfering

"RNA, Small Interfering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.

Descriptor ID	D034741
MeSH Number(s)	D13.150.650.700 D13.444.735.150.700 D13.444.735.790.552.875
Concept/Terms	RNA, Small Interfering RNA, Small Interfering Interfering RNA, Small Short Interfering RNA Interfering RNA, Short RNA, Short Interfering Small Interfering RNA siRNA Piwi-Interacting RNA Piwi-Interacting RNA Piwi Interacting RNA RNA, Piwi-Interacting RNA, Piwi Interacting piRNA Short Hairpin RNA Short Hairpin RNA Hairpin RNA, Short RNA, Short Hairpin Small Hairpin RNA Hairpin RNA, Small RNA, Small Hairpin shRNA Repeat-Associated siRNA Repeat-Associated siRNA Repeat Associated siRNA siRNA, Repeat-Associated siRNA, Repeat Associated Scan RNA Scan RNA scnRNA Small Scan RNA RNA, Small Scan Scan RNA, Small RNA, Scan Trans-Acting siRNA Trans-Acting siRNA Trans Acting siRNA tasiRNA siRNA, Trans-Acting siRNA, Trans Acting

Below are MeSH descriptors whose meaning is more general than "RNA, Small Interfering".

Chemicals and Drugs [D]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Antisense Elements (Genetics) [D13.150]
RNA, Antisense [D13.150.650]
RNA, Small Interfering [D13.150.650.700]
Nucleic Acids [D13.444]
RNA [D13.444.735]
RNA, Antisense [D13.444.735.150]
RNA, Small Interfering [D13.444.735.150.700]
RNA, Untranslated [D13.444.735.790]
RNA, Small Untranslated [D13.444.735.790.552]
RNA, Small Interfering [D13.444.735.790.552.875]

Below are MeSH descriptors whose meaning is related to "RNA, Small Interfering".

Below are MeSH descriptors whose meaning is more specific than "RNA, Small Interfering".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "RNA, Small Interfering" by people in this website by year, and whether "RNA, Small Interfering" was a major or minor topic of these publications.

Bar chart showing 241 publications over 21 distinct years, with a maximum of 30 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	1	5	6
2004	4	6	10
2005	0	12	12
2006	4	13	17
2007	3	21	24
2008	1	19	20
2009	5	24	29
2010	2	22	24
2011	5	25	30
2012	2	12	14
2013	3	14	17
2014	1	6	7
2015	0	5	5
2016	2	5	7
2017	0	3	3
2018	1	1	2
2019	0	1	1
2020	0	5	5
2021	2	2	4
2022	0	3	3

Below are the most recent publications written about "RNA, Small Interfering" by people in Profiles.

Ventura E, Xie C, Buraschi S, Belfiore A, Iozzo RV, Giordano A, Morrione A. Complexity of progranulin mechanisms of action in mesothelioma. J Exp Clin Cancer Res. 2022 Dec 05; 41(1):333.

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Roh EH, Sullivan MO, Epps TH. A kinetic modeling platform for predicting the efficacy of siRNA formulations in?vitro and in?vivo. STAR Protoc. 2022 12 16; 3(4):101723.

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Celik B, Cicek K, Leal AF, Tomatsu S. Regulation of Molecular Targets in Osteosarcoma Treatment. Int J Mol Sci. 2022 Oct 20; 23(20).

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Krieger LM, Mladenov E, Soni A, Demond M, Stuschke M, Iliakis G. Disruption of Chromatin Dynamics by Hypotonic Stress Suppresses HR and Shifts DSB Processing to Error-Prone SSA. Int J Mol Sci. 2021 Oct 11; 22(20).

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Marom R, Burrage LC, Venditti R, Cl?ment A, Blanco-S?nchez B, Jain M, Scott DA, Rosenfeld JA, Sutton VR, Shinawi M, Mirzaa G, DeVile C, Roberts R, Calder AD, Allgrove J, Grafe I, Lanza DG, Li X, Joeng KS, Lee YC, Song IW, Sliepka JM, Batkovskyte D, Washington M, Dawson BC, Jin Z, Jiang MM, Chen S, Chen Y, Tran AA, Emrick LT, Murdock DR, Hanchard NA, Zapata GE, Mehta NR, Weis MA, Scott AA, Tremp BA, Phillips JB, Wegner J, Taylor-Miller T, Gibbs RA, Muzny DM, Jhangiani SN, Hicks J, Stottmann RW, Dickinson ME, Seavitt JR, Heaney JD, Eyre DR, Westerfield M, De Matteis MA, Lee B. COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay. Am J Hum Genet. 2021 09 02; 108(9):1710-1724.

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Bisserier M, Katz MG, Bueno-Beti C, Brojakowska A, Zhang S, Gubara S, Kohlbrenner E, Fazal S, Fargnoli A, Dorfmuller P, Humbert M, Hata A, Goukassian DA, Sassi Y, Hadri L. Combination Therapy with STAT3 Inhibitor Enhances SERCA2a-Induced BMPR2 Expression and Inhibits Pulmonary Arterial Hypertension. Int J Mol Sci. 2021 Aug 24; 22(17).

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Shigematsu M, Kawamura T, Morichika K, Izumi N, Kiuchi T, Honda S, Pliatsika V, Matsubara R, Rigoutsos I, Katsuma S, Tomari Y, Kirino Y. RNase ? promotes robust piRNA production by generating 2',3'-cyclic phosphate-containing precursors. Nat Commun. 2021 07 23; 12(1):4498.

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Layer JV, Debaize L, Van Scoyk A, House NC, Brown AJ, Liu Y, Stevenson KE, Hemann M, Roberts SA, Price BD, Weinstock DM, Day TA. Polymerase d promotes chromosomal rearrangements and imprecise double-strand break repair. Proc Natl Acad Sci U S A. 2020 11 03; 117(44):27566-27577.

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Hoshijima M, Hattori T, Aoyama E, Nishida T, Kubota S, Kamioka H, Takigawa M. Roles of Interaction between CCN2 and Rab14 in Aggrecan Production by Chondrocytes. Int J Mol Sci. 2020 Apr 16; 21(8).

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Shenoda BB, Ramanathan S, Gupta R, Tian Y, Jean-Toussaint R, Alexander GM, Addya S, Somarowthu S, Sacan A, Ajit SK. Xist attenuates acute inflammatory response by female cells. Cell Mol Life Sci. 2021 Jan; 78(1):299-316.

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