"Receptor, EphA2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An Eph family receptor found abundantly in tissues of epithelial origin. It is expressed in a diverse array of tissues during embryonic development, suggesting that it may play a role in embryogenesis. In adult tissues high levels of the receptor are expressed in the LUNG; SKIN; SMALL INTESTINE and OVARY.
| Descriptor ID |
D036104
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| MeSH Number(s) |
D08.811.913.696.620.682.725.400.850.100 D12.776.543.750.630.500.100
|
| Concept/Terms |
Receptor, EphA2- Receptor, EphA2
- Epithelial Cell Kinase Protein
- EphA2 Receptor
- EphA2-Tyrosine Kinase
- EphA2 Tyrosine Kinase
- EphA2 Receptor Tyrosine Kinase
- EphA2 Protein
- Mammary-Derived Tyrosine Kinase 2
- Mammary Derived Tyrosine Kinase 2
|
Below are MeSH descriptors whose meaning is more general than "Receptor, EphA2".
Below are MeSH descriptors whose meaning is more specific than "Receptor, EphA2".
This graph shows the total number of publications written about "Receptor, EphA2" by people in this website by year, and whether "Receptor, EphA2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2024 | 2 | 0 | 2 |
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Below are the most recent publications written about "Receptor, EphA2" by people in Profiles.
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Toracchio L, Carrabotta M, Mancarella C, Morrione A, Scotlandi K. EphA2 in Cancer: Molecular Complexity and Therapeutic Opportunities. Int J Mol Sci. 2024 Nov 13; 25(22).
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Bashir B, Wang JS, Falchook G, Fontana E, Arkenau HT, Carter L, Galot R, Basu B, Greystoke A, Subbiah V, Richardson DL, Orr H, Bennett G, Sharma R, Xu H, Paganoni P, Xu C, Campbell C, McKean M. Results From First-in-Human Phase I Dose-Escalation Study of a Novel Bicycle Toxin Conjugate Targeting EphA2 (BT5528) in Patients With Advanced Solid Tumors. J Clin Oncol. 2024 Oct 10; 42(29):3443-3452.
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Buraschi S, Neill T, Xu SQ, Palladino C, Belfiore A, Iozzo RV, Morrione A. Progranulin/EphA2 axis: A novel oncogenic mechanism in bladder cancer. Matrix Biol. 2020 11; 93:10-24.
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Logan CM, Rajakaruna S, Bowen C, Radice GL, Robinson ML, Menko AS. N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis. Dev Biol. 2017 08 01; 428(1):118-134.
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Neill T, Buraschi S, Goyal A, Sharpe C, Natkanski E, Schaefer L, Morrione A, Iozzo RV. EphA2 is a functional receptor for the growth factor progranulin. J Cell Biol. 2016 Dec 05; 215(5):687-703.
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Nishimura M, Jung EJ, Shah MY, Lu C, Spizzo R, Shimizu M, Han HD, Ivan C, Rossi S, Zhang X, Nicoloso MS, Wu SY, Almeida MI, Bottsford-Miller J, Pecot CV, Zand B, Matsuo K, Shahzad MM, Jennings NB, Rodriguez-Aguayo C, Lopez-Berestein G, Sood AK, Calin GA. Therapeutic synergy between microRNA and siRNA in ovarian cancer treatment. Cancer Discov. 2013 Nov; 3(11):1302-15.