"Integrin alpha5beta1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.
| Descriptor ID |
D039081
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| MeSH Number(s) |
D12.776.395.550.625.379 D12.776.543.550.625.379 D12.776.543.750.705.408.530.750 D12.776.543.750.705.408.850.349 D12.776.543.750.705.675.460 D12.776.543.750.705.876.374
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| Concept/Terms |
Integrin alpha5beta1- Integrin alpha5beta1
- alpha5beta1, Integrin
- Integrin alpha-5 beta-1
- Integrin alpha 5 beta 1
- alpha-5 beta-1, Integrin
- beta-1, Integrin alpha-5
- Platelet Glycoprotein Ic-IIa
- Glycoprotein Ic-IIa, Platelet
- Ic-IIa, Platelet Glycoprotein
- Platelet Glycoprotein Ic IIa
- VLA-5
- VLA-5 Receptors
- VLA 5 Receptors
- Fibronectin Receptor
- Receptor, Fibronectin
- Receptors, VLA-5
- Receptors, VLA 5
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha5beta1".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha5beta1".
This graph shows the total number of publications written about "Integrin alpha5beta1" by people in this website by year, and whether "Integrin alpha5beta1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2010 | 2 | 0 | 2 |
| 2011 | 1 | 2 | 3 |
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Below are the most recent publications written about "Integrin alpha5beta1" by people in Profiles.
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Lee B, Clarke D, Al Ahmad A, Kahle M, Parham C, Auckland L, Shaw C, Fidanboylu M, Orr AW, Ogunshola O, Fertala A, Thomas SA, Bix GJ. Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents. J Clin Invest. 2011 Aug; 121(8):3005-23.
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Pulina MV, Hou SY, Mittal A, Julich D, Whittaker CA, Holley SA, Hynes RO, Astrof S. Essential roles of fibronectin in the development of the left-right embryonic body plan. Dev Biol. 2011 Jun 15; 354(2):208-20.
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Bell-McGuinn KM, Matthews CM, Ho SN, Barve M, Gilbert L, Penson RT, Lengyel E, Palaparthy R, Gilder K, Vassos A, McAuliffe W, Weymer S, Barton J, Schilder RJ. A phase II, single-arm study of the anti-a5ß1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer. Gynecol Oncol. 2011 May 1; 121(2):273-9.
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Roman J, Ritzenthaler JD, Roser-Page S, Sun X, Han S. alpha5beta1-integrin expression is essential for tumor progression in experimental lung cancer. Am J Respir Cell Mol Biol. 2010 Dec; 43(6):684-91.
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McIlhenny SE, Hager ES, Grabo DJ, DiMatteo C, Shapiro IM, Tulenko TN, DiMuzio PJ. Linear shear conditioning improves vascular graft retention of adipose-derived stem cells by upregulation of the alpha5beta1 integrin. Tissue Eng Part A. 2010 Jan; 16(1):245-55.
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Zheng Y, Ritzenthaler JD, Roman J, Han S. Nicotine stimulates human lung cancer cell growth by inducing fibronectin expression. Am J Respir Cell Mol Biol. 2007 Dec; 37(6):681-90.
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Han S, Ritzenthaler JD, Wingerd B, Rivera HN, Roman J. Extracellular matrix fibronectin increases prostaglandin E2 receptor subtype EP4 in lung carcinoma cells through multiple signaling pathways: the role of AP-2. J Biol Chem. 2007 Mar 16; 282(11):7961-72.
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Han S, Khuri FR, Roman J. Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways. Cancer Res. 2006 Jan 01; 66(1):315-23.
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Roman J, Ritzenthaler JD, Boles B, Lois M, Roser-Page S. Lipopolysaccharide induces expression of fibronectin alpha 5 beta 1-integrin receptors in human monocytic cells in a protein kinase C-dependent fashion. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L239-49.