"Integrin alpha6beta1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
| Descriptor ID |
D039121
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| MeSH Number(s) |
D12.776.395.550.625.419 D12.776.543.550.625.419 D12.776.543.750.705.408.850.674 D12.776.543.750.705.675.514 D12.776.543.750.705.876.500
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| Concept/Terms |
Integrin alpha6beta1- Integrin alpha6beta1
- alpha6beta1, Integrin
- alpha6beta1 Integrin
- Integrin, alpha6beta1
- VLA-6
- VLA 6
- Integrin alpha(6)beta(1)
- Platelet Glycoprotein I'c-IIa
- Glycoprotein I'c-IIa, Platelet
- I'c-IIa, Platelet Glycoprotein
- Platelet Glycoprotein I'c IIa
- alpha 6 beta 1 Integrin
- CD49f-CD29
- CD49f CD29
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Below are MeSH descriptors whose meaning is more general than "Integrin alpha6beta1".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha6beta1".
This graph shows the total number of publications written about "Integrin alpha6beta1" by people in this website by year, and whether "Integrin alpha6beta1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
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Below are the most recent publications written about "Integrin alpha6beta1" by people in Profiles.
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Dai JY, Dou KF, Wang CH, Zhao P, Lau WB, Tao L, Wu YM, Tang J, Jiang JL, Chen ZN. The interaction of HAb18G/CD147 with integrin alpha6beta1 and its implications for the invasion potential of human hepatoma cells. BMC Cancer. 2009; 9:337.
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Vafa A, Zhang Y, Sikes RA, Marengo SR. Overexpression of p185erbB2/neu in the NbE prostatic epithelial cell line increases cellular spreading and the expression of integrin alpha6beta1. Int J Oncol. 1998 Dec; 13(6):1191-7.
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Enomoto-Iwamoto M, Menko AS, Philp N, Boettiger D. Evaluation of integrin molecules involved in substrate adhesion. Cell Adhes Commun. 1993 Dec; 1(3):191-202.