"Integrin alpha5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
This integrin alpha subunit combines with INTEGRIN BETA1 to form a receptor (INTEGRIN ALPHA5BETA1) that binds FIBRONECTIN and LAMININ. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds.
Descriptor ID |
D039482
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MeSH Number(s) |
D12.776.543.750.705.408.100.500
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Concept/Terms |
Integrin alpha5- Integrin alpha5
- alpha5, Integrin
- alpha(5) Integrin
- alpha5 Integrin
- Integrin, alpha5
- VLA-5 alpha Chain
- VLA 5 alpha Chain
- alpha Chain, VLA-5
- CD49e Antigens
- Platelet Glycoprotein Ic
- Glycoprotein Ic, Platelet
- Ic, Platelet Glycoprotein
- Integrin alphaF
- alphaF, Integrin
- CD49e Antigen
- Antigen, CD49e
- Antigens, CD49e
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha5".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha5".
This graph shows the total number of publications written about "Integrin alpha5" by people in this website by year, and whether "Integrin alpha5" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2001 | 0 | 1 | 1 |
2005 | 2 | 0 | 2 |
2007 | 0 | 1 | 1 |
2010 | 1 | 1 | 2 |
2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Integrin alpha5" by people in Profiles.
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Li X, McLain C, Samuel MS, Olson MF, Radice GL. Actomyosin-mediated cellular tension promotes Yap nuclear translocation and myocardial proliferation through a5 integrin signaling. Development. 2023 Jan 15; 150(2).
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Mittal A, Pulina M, Hou SY, Astrof S. Fibronectin and integrin alpha 5 play essential roles in the development of the cardiac neural crest. Mech Dev. 2010 Sep-Dec; 127(9-12):472-84.
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Goel HL, Underwood JM, Nickerson JA, Hsieh CC, Languino LR. Beta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1. J Cell Physiol. 2010 Jul; 224(1):210-7.
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Kolachala VL, Bajaj R, Wang L, Yan Y, Ritzenthaler JD, Gewirtz AT, Roman J, Merlin D, Sitaraman SV. Epithelial-derived fibronectin expression, signaling, and function in intestinal inflammation. J Biol Chem. 2007 Nov 09; 282(45):32965-73.
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Han S, Roman J. COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk: involvement of Sp1 and AP-1 sites. Int J Cancer. 2005 Sep 10; 116(4):536-46.
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Han S, Rivera HN, Roman J. Peroxisome proliferator-activated receptor-gamma ligands inhibit alpha5 integrin gene transcription in non-small cell lung carcinoma cells. Am J Respir Cell Mol Biol. 2005 Apr; 32(4):350-9.
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Menko AS, Kreidberg JA, Ryan TT, Van Bockstaele E, Kukuruzinska MA. Loss of alpha3beta1 integrin function results in an altered differentiation program in the mouse submandibular gland. Dev Dyn. 2001 Apr; 220(4):337-49.