"Integrin alpha6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin alpha subunit that primarily associates with INTEGRIN BETA1 or INTEGRIN BETA4 to form laminin-binding heterodimers. Integrin alpha6 has two alternatively spliced isoforms: integrin alpha6A and integrin alpha6B, which differ in their cytoplasmic domains and are regulated in a tissue-specific and developmental stage-specific manner.
| Descriptor ID |
D039503
|
| MeSH Number(s) |
D12.776.543.750.705.408.100.550
|
| Concept/Terms |
Integrin alpha6- Integrin alpha6
- alpha6, Integrin
- CD49f Antigens
- alpha6 Integrin
- Integrin, alpha6
- Antigens, CD49f
- CD49f Antigen
- Antigen, CD49f
- alpha(6) Integrin
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha6".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha6".
This graph shows the total number of publications written about "Integrin alpha6" by people in this website by year, and whether "Integrin alpha6" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2002 | 1 | 2 | 3 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 1 | 1 | 2 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Integrin alpha6" by people in Profiles.
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Barzegar M, Asadi-Kani Z, Mozafari N, Vahidnezhad H, Kariminejad A, Toossi P. Using immunofluorescence (antigen) mapping in the diagnosis and classification of epidermolysis bullosa: a first report from Iran. Int J Dermatol. 2015 Oct; 54(10):e416-23.
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Basu S, Rajakaruna S, De Arcangelis A, Zhang L, Georges-Labouesse E, Menko AS. a6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation. J Biol Chem. 2014 Feb 14; 289(7):3842-55.
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Dayal JH, Cole CL, Pourreyron C, Watt SA, Lim YZ, Salas-Alanis JC, Murrell DF, McGrath JA, Stieger B, Jahoda C, Leigh IM, South AP. Type VII collagen regulates expression of OATP1B3, promotes front-to-rear polarity and increases structural organisation in 3D spheroid cultures of RDEB tumour keratinocytes. J Cell Sci. 2014 Feb 15; 127(Pt 4):740-51.
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Menko AS, Andley UP. aA-Crystallin associates with a6 integrin receptor complexes and regulates cellular signaling. Exp Eye Res. 2010 Nov; 91(5):640-51.
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Chandramouly G, Abad PC, Knowles DW, Leli?vre SA. The control of tissue architecture over nuclear organization is crucial for epithelial cell fate. J Cell Sci. 2007 May 01; 120(Pt 9):1596-606.
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Gonzalez-Angulo AM, Sahin A, Krishnamurthy S, Yang Y, Kau SW, Hortobagyi GN, Cristofanilli M. Biologic markers in axillary node-negative breast cancer: differential expression in invasive ductal carcinoma versus invasive lobular carcinoma. Clin Breast Cancer. 2006 Dec; 7(5):396-400.
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Walker JL, Zhang L, Menko AS. A signaling role for the uncleaved form of alpha 6 integrin in differentiating lens fiber cells. Dev Biol. 2002 Nov 15; 251(2):195-205.
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Walker JL, Zhang L, Menko AS. Transition between proliferation and differentiation for lens epithelial cells is regulated by Src family kinases. Dev Dyn. 2002 Aug; 224(4):361-72.
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Walker JL, Zhang L, Zhou J, Woolkalis MJ, Menko AS. Role for alpha 6 integrin during lens development: Evidence for signaling through IGF-1R and ERK. Dev Dyn. 2002 Mar; 223(2):273-84.
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Walker JL, Menko AS. alpha6 Integrin is regulated with lens cell differentiation by linkage to the cytoskeleton and isoform switching. Dev Biol. 1999 Jun 15; 210(2):497-511.