Vascular Endothelial Growth Factor Receptor-2

"Vascular Endothelial Growth Factor Receptor-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.

Descriptor ID	D040301
MeSH Number(s)	D08.811.913.696.620.682.725.400.950.200 D12.776.543.750.630.750.200 D12.776.543.750.750.400.910.200
Concept/Terms	Vascular Endothelial Growth Factor Receptor-2 Vascular Endothelial Growth Factor Receptor-2 Vascular Endothelial Growth Factor Receptor 2 KDR Tyrosine Kinase Tyrosine Kinase, KDR VEGFR-2 Fetal Liver Kinase-1 Fetal Liver Kinase 1 Kinase Insert Domain Receptor VEGF Receptor Flk-1 Flk-1, VEGF Receptor VEGF Receptor Flk 1 VEGF Receptor KDR KDR, VEGF Receptor Flk-1 Protein Flk 1 Protein Flk-1 Receptor Tyrosine Kinase Flk 1 Receptor Tyrosine Kinase

Below are MeSH descriptors whose meaning is more general than "Vascular Endothelial Growth Factor Receptor-2".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
Receptors, Vascular Endothelial Growth Factor [D08.811.913.696.620.682.725.400.950]
Vascular Endothelial Growth Factor Receptor-2 [D08.811.913.696.620.682.725.400.950.200]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
Receptors, Vascular Endothelial Growth Factor [D12.776.543.750.630.750]
Vascular Endothelial Growth Factor Receptor-2 [D12.776.543.750.630.750.200]
Receptors, Peptide [D12.776.543.750.750]
Receptors, Growth Factor [D12.776.543.750.750.400]
Receptors, Vascular Endothelial Growth Factor [D12.776.543.750.750.400.910]
Vascular Endothelial Growth Factor Receptor-2 [D12.776.543.750.750.400.910.200]

Below are MeSH descriptors whose meaning is related to "Vascular Endothelial Growth Factor Receptor-2".

Below are MeSH descriptors whose meaning is more specific than "Vascular Endothelial Growth Factor Receptor-2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Vascular Endothelial Growth Factor Receptor-2" by people in this website by year, and whether "Vascular Endothelial Growth Factor Receptor-2" was a major or minor topic of these publications.

Bar chart showing 54 publications over 19 distinct years, with a maximum of 6 publications in 2013 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	1	0	1
2004	1	0	1
2005	2	0	2
2007	2	0	2
2008	2	0	2
2009	2	1	3
2010	3	1	4
2011	1	2	3
2012	3	2	5
2013	1	5	6
2014	2	2	4
2015	5	1	6
2016	2	1	3
2017	0	2	2
2018	1	1	2
2019	2	0	2
2020	1	1	2
2021	0	3	3
2024	1	0	1

Below are the most recent publications written about "Vascular Endothelial Growth Factor Receptor-2" by people in Profiles.

Ramirez A, Vyzas CA, Zhao H, Eng K, Degenhardt K, Astrof S. Buffering Mechanism in Aortic Arch Artery Formation and Congenital Heart Disease. Circ Res. 2024 May 10; 134(10):e112-e132.

View in: PubMed
Srour AM, Panda SS, Mostafa A, Fayad W, El-Manawaty MA, A F Soliman A, Moatasim Y, El Taweel A, Abdelhameed MF, Bekheit MS, Ali MA, Girgis AS. Synthesis of aspirin-curcumin mimic conjugates of potential antitumor and anti-SARS-CoV-2 properties. Bioorg Chem. 2021 12; 117:105466.

View in: PubMed
Balne PK, Gupta S, Zhang J, Bristow D, Faubion M, Heil SD, Sinha PR, Green SL, Iozzo RV, Mohan RR. The functional role of decorin in corneal neovascularization in vivo. Exp Eye Res. 2021 06; 207:108610.

View in: PubMed
Harding JJ, Do RK, Yaqubie A, Cleverly A, Zhao Y, Gueorguieva I, Lahn M, Benhadji KA, Kelley RK, Abou-Alfa GK. Phase 1b study of galunisertib and ramucirumab in patients with advanced hepatocellular carcinoma. Cancer Med. 2021 05; 10(9):3059-3067.

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Chen CG, Iozzo RV. Angiostatic cues from the matrix: Endothelial cell autophagy meets hyaluronan biology. J Biol Chem. 2020 12 04; 295(49):16797-16812.

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Neill T, Buraschi S, Kapoor A, Iozzo RV. Proteoglycan-driven Autophagy: A Nutrient-independent Mechanism to Control Intracellular Catabolism. J Histochem Cytochem. 2020 11; 68(11):733-746.

View in: PubMed
Disel U, Madison R, Abhishek K, Chung JH, Trabucco SE, Matos AO, Frampton GM, Albacker LA, Reddy V, Karadurmus N, Benson A, Webster J, Paydas S, Cabanillas R, Nangia C, Ozturk MA, Millis SZ, Pal SK, Wilky B, Sokol ES, Gay LM, Soman S, Ganesan S, Janeway K, Stephens PJ, Zhu VW, Ou SI, Lovly CM, Gounder M, Schrock AB, Ross JS, Miller VA, Klempner SJ, Ali SM. The Pan-Cancer Landscape of Coamplification of the Tyrosine Kinases KIT, KDR, and PDGFRA. Oncologist. 2020 01; 25(1):e39-e47.

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Pellicani R, Poletto E, Andreuzzi E, Paulitti A, Doliana R, Bizzotto D, Braghetta P, Colladel R, Tarticchio G, Sabatelli P, Bucciotti F, Bressan G, Iozzo RV, Colombatti A, Bonaldo P, Mongiat M. Multimerin-2 maintains vascular stability and permeability. Matrix Biol. 2020 05; 87:11-25.

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Marks ECA, Wilkinson TM, Frampton CM, Skelton L, Pilbrow AP, Yandle TG, Pemberton CJ, Doughty RN, Whalley GA, Ellis CJ, Troughton RW, Owen MC, Pattinson NR, Cameron VA, Richards AM, Gieseg SP, Palmer BR. Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes. BMC Cardiovasc Disord. 2018 08 15; 18(1):169.

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Neill T, Andreuzzi E, Wang ZX, Peiper SC, Mongiat M, Iozzo RV. Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature. J Biol Chem. 2018 08 03; 293(31):12137-12148.

View in: PubMed

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