"Thymine DNA Glycosylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that removes THYMINE and URACIL bases mispaired with GUANINE through hydrolysis of their N-glycosidic bond. These mispaired nucleotides generally occur through the hydrolytic DEAMINATION of 5-METHYLCYTOSINE to thymine.
| Descriptor ID |
D044502
|
| MeSH Number(s) |
D08.811.074.249.750 D08.811.277.450.430.099.750
|
| Concept/Terms |
Thymine DNA Glycosylase- Thymine DNA Glycosylase
- DNA Glycosylase, Thymine
- Glycosylase, Thymine DNA
- Thymine Glycol Glycosylase
- Glycol Glycosylase, Thymine
- Glycosylase, Thymine Glycol
- G-T Mismatch-Specific Thymine DNA Glycosylase
- G T Mismatch Specific Thymine DNA Glycosylase
- Thymine Glycol DNA Glycosylase
|
Below are MeSH descriptors whose meaning is more general than "Thymine DNA Glycosylase".
Below are MeSH descriptors whose meaning is more specific than "Thymine DNA Glycosylase".
This graph shows the total number of publications written about "Thymine DNA Glycosylase" by people in this website by year, and whether "Thymine DNA Glycosylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 |
| 2013 | 2 | 0 | 2 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Thymine DNA Glycosylase" by people in Profiles.
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Tricarico R, Madzo J, Scher G, Cohen M, Jelinek J, Maegawa S, Nagarathinam R, Scher C, Chang WC, Nicolas E, Slifker M, Zhou Y, Devarajan K, Cai KQ, Kwok T, Nakajima P, Xu J, Mancuso P, Doneddu V, Bagella L, Williams R, Balachandran S, Maskalenko N, Campbell K, Ma X, Ca?adas I, Viana-Errasti J, Moreno V, Valle L, Grivennikov S, Peshkova I, Kurilenko N, Mazitova A, Koltsova E, Lee H, Walsh M, Duttweiler R, Whetstine JR, Yen TJ, Issa JP, Bellacosa A. TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype. Gastroenterology. 2023 05; 164(6):921-936.e1.
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Hashimoto H, Zhang X, Cheng X. Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH. DNA Repair (Amst). 2013 Jul; 12(7):535-40.
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Hashimoto H, Zhang X, Cheng X. Selective excision of 5-carboxylcytosine by a thymine DNA glycosylase mutant. J Mol Biol. 2013 Mar 25; 425(6):971-6.
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Cortellino S, Xu J, Sannai M, Moore R, Caretti E, Cigliano A, Le Coz M, Devarajan K, Wessels A, Soprano D, Abramowitz LK, Bartolomei MS, Rambow F, Bassi MR, Bruno T, Fanciulli M, Renner C, Klein-Szanto AJ, Matsumoto Y, Kobi D, Davidson I, Alberti C, Larue L, Bellacosa A. Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell. 2011 Jul 08; 146(1):67-79.