"Flap Endonucleases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.
| Descriptor ID |
D045585
|
| MeSH Number(s) |
D08.811.277.352.355.325.350
|
| Concept/Terms |
Flap Endonuclease-1- Flap Endonuclease-1
- Endonuclease-1, Flap
- Flap Endonuclease 1
- RTH-1 Nuclease
- Nuclease, RTH-1
- RTH 1 Nuclease
- RAD2 Homolog-1 Nuclease
- RAD2 Homolog 1 Nuclease
- FEN-1
- Fen1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Flap Endonucleases".
Below are MeSH descriptors whose meaning is more specific than "Flap Endonucleases".
This graph shows the total number of publications written about "Flap Endonucleases" by people in this website by year, and whether "Flap Endonucleases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
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Below are the most recent publications written about "Flap Endonucleases" by people in Profiles.
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Kalifa L, Beutner G, Phadnis N, Sheu SS, Sia EA. Evidence for a role of FEN1 in maintaining mitochondrial DNA integrity. DNA Repair (Amst). 2009 Oct 2; 8(10):1242-9.
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Casta LJ, Buguliskis JS, Matsumoto Y, Taraschi TF. Expression and biochemical characterization of the Plasmodium falciparum DNA repair enzyme, flap endonuclease-1 (PfFEN-1). Mol Biochem Parasitol. 2008 Jan; 157(1):1-12.
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Negritto MC, Qiu J, Ratay DO, Shen B, Bailis AM. Novel function of Rad27 (FEN-1) in restricting short-sequence recombination. Mol Cell Biol. 2001 Apr; 21(7):2349-58.
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Haltiwanger BM, Matsumoto Y, Nicolas E, Dianov GL, Bohr VA, Taraschi TF. DNA base excision repair in human malaria parasites is predominantly by a long-patch pathway. Biochemistry. 2000 Feb 01; 39(4):763-72.