STAT1 Transcription Factor
"STAT1 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducer and activator of transcription that mediates cellular responses to INTERFERONS. Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS.
| Descriptor ID |
D050794
|
| MeSH Number(s) |
D12.644.360.024.303.500.500 D12.644.360.024.342.100 D12.776.157.057.061.500.500 D12.776.157.057.186.100 D12.776.260.513.249.500 D12.776.476.024.386.500.500 D12.776.476.024.430.100 D12.776.930.354.249.500 D12.776.930.840.100
|
| Concept/Terms |
STAT1 Transcription Factor- STAT1 Transcription Factor
- Transcription Factor, STAT1
- Transcription Factor STAT91
- Gamma-Activated Factor, 91 kDa
- Gamma Activated Factor, 91 kDa
- STAT-91 Transcription Factor
- STAT 91 Transcription Factor
- Transcription Factor, STAT-91
- STAT-91 Protein
- STAT 91 Protein
- STAT91 Transcription Factor
- Transcription Factor, STAT91
- STAT1 Protein
- Signal Transducer and Activator of Transcription 1
|
Below are MeSH descriptors whose meaning is more general than "STAT1 Transcription Factor".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- Adaptor Proteins, Signal Transducing [D12.644.360.024]
- Interferon-Stimulated Gene Factor 3 [D12.644.360.024.303]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.644.360.024.303.500]
- STAT1 Transcription Factor [D12.644.360.024.303.500.500]
- STAT Transcription Factors [D12.644.360.024.342]
- STAT1 Transcription Factor [D12.644.360.024.342.100]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Adaptor Proteins, Signal Transducing [D12.776.157.057]
- Interferon-Stimulated Gene Factor 3 [D12.776.157.057.061]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.157.057.061.500]
- STAT1 Transcription Factor [D12.776.157.057.061.500.500]
- STAT Transcription Factors [D12.776.157.057.186]
- STAT1 Transcription Factor [D12.776.157.057.186.100]
- DNA-Binding Proteins [D12.776.260]
- Interferon-Stimulated Gene Factor 3 [D12.776.260.513]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.260.513.249]
- STAT1 Transcription Factor [D12.776.260.513.249.500]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- Adaptor Proteins, Signal Transducing [D12.776.476.024]
- Interferon-Stimulated Gene Factor 3 [D12.776.476.024.386]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.476.024.386.500]
- STAT1 Transcription Factor [D12.776.476.024.386.500.500]
- STAT Transcription Factors [D12.776.476.024.430]
- STAT1 Transcription Factor [D12.776.476.024.430.100]
- Transcription Factors [D12.776.930]
- Interferon-Stimulated Gene Factor 3 [D12.776.930.354]
- Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.930.354.249]
- STAT1 Transcription Factor [D12.776.930.354.249.500]
- STAT Transcription Factors [D12.776.930.840]
- STAT1 Transcription Factor [D12.776.930.840.100]
Below are MeSH descriptors whose meaning is more specific than "STAT1 Transcription Factor".
This graph shows the total number of publications written about "STAT1 Transcription Factor" by people in this website by year, and whether "STAT1 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 3 | 4 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 2 | 0 | 2 |
| 2016 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "STAT1 Transcription Factor" by people in Profiles.
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Tao Y, Zhang X, Markovic-Plese S. Toll-like receptor (TLR)7 and TLR9 agonists enhance interferon (IFN) beta-1a's immunoregulatory effects on B cells in patients with relapsing-remitting multiple sclerosis (RRMS). J Neuroimmunol. 2016 09 15; 298:181-8.
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Lin CC, Jiang W, Mitra R, Cheng F, Yu H, Zhao Z. Regulation rewiring analysis reveals mutual regulation between STAT1 and miR-155-5p in tumor immunosurveillance in seven major cancers. Sci Rep. 2015 Jul 09; 5:12063.
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Mounayar M, Kefaloyianni E, Smith B, Solhjou Z, Maarouf OH, Azzi J, Chabtini L, Fiorina P, Kraus M, Briddell R, Fodor W, Herrlich A, Abdi R. PI3ka and STAT1 Interplay Regulates Human Mesenchymal Stem Cell Immune Polarization. Stem Cells. 2015 Jun; 33(6):1892-901.
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Basu S, Rajakaruna S, De Arcangelis A, Zhang L, Georges-Labouesse E, Menko AS. a6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation. J Biol Chem. 2014 Feb 14; 289(7):3842-55.
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Stankiewicz TR, Loucks FA, Schroeder EK, Nevalainen MT, Tyler KL, Aktories K, Bouchard RJ, Linseman DA. Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity. J Biol Chem. 2012 May 11; 287(20):16835-48.
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Li H, Nourbakhsh B, Cullimore M, Zhang GX, Rostami A. IL-9 is important for T-cell activation and differentiation in autoimmune inflammation of the central nervous system. Eur J Immunol. 2011 Aug; 41(8):2197-206.
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Koksal AC, Cingolani G. Dimerization of Vaccinia virus VH1 is essential for dephosphorylation of STAT1 at tyrosine 701. J Biol Chem. 2011 Apr 22; 286(16):14373-82.
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HuangFu WC, Qian J, Liu C, Rui H, Fuchs SY. Melanoma cell-secreted soluble factor that stimulates ubiquitination and degradation of the interferon alpha receptor and attenuates its signaling. Pigment Cell Melanoma Res. 2010 Dec; 23(6):838-40.
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Nardozzi J, Wenta N, Yasuhara N, Vinkemeier U, Cingolani G. Molecular basis for the recognition of phosphorylated STAT1 by importin alpha5. J Mol Biol. 2010 Sep 10; 402(1):83-100.
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El-behi M, Ciric B, Yu S, Zhang GX, Fitzgerald DC, Rostami A. Differential effect of IL-27 on developing versus committed Th17 cells. J Immunol. 2009 Oct 15; 183(8):4957-67.