Focal Adhesion Kinase 2

"Focal Adhesion Kinase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A non-receptor protein-tyrosine kinase that is expressed primarily in the BRAIN; OSTEOBLASTS; and LYMPHOID CELLS. In the CENTRAL NERVOUS SYSTEM focal adhesion kinase 2 modulates ION CHANNEL function and MITOGEN-ACTIVATED PROTEIN KINASES activity.

Descriptor ID	D051418
MeSH Number(s)	D08.811.913.696.620.682.725.049.750 D23.050.301.500.600.350 D23.050.705.552.600.350
Concept/Terms	Focal Adhesion Kinase 2 Focal Adhesion Kinase 2 RAFTK Protein Cell Adhesion Kinase Beta Proline-Rich Tyrosine Kinase 2 Proline Rich Tyrosine Kinase 2 Related Adhesion Focal Tyrosine Kinase CADTK Protein Focal Adhesion Kinase Autokinase FAK Autokinase Calcium-Dependent Protein Tyrosine Kinase Calcium Dependent Protein Tyrosine Kinase PYK2 Protein Tyrosine Kinase Protein Tyrosine Kinase PYK2

Below are MeSH descriptors whose meaning is more general than "Focal Adhesion Kinase 2".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Focal Adhesion Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.049]
Focal Adhesion Kinase 2 [D08.811.913.696.620.682.725.049.750]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Surface [D23.050.301]
Histocompatibility Antigens [D23.050.301.500]
Minor Histocompatibility Antigens [D23.050.301.500.600]
Focal Adhesion Kinase 2 [D23.050.301.500.600.350]
Isoantigens [D23.050.705]
Histocompatibility Antigens [D23.050.705.552]
Minor Histocompatibility Antigens [D23.050.705.552.600]
Focal Adhesion Kinase 2 [D23.050.705.552.600.350]

Below are MeSH descriptors whose meaning is related to "Focal Adhesion Kinase 2".

Below are MeSH descriptors whose meaning is more specific than "Focal Adhesion Kinase 2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Focal Adhesion Kinase 2" by people in this website by year, and whether "Focal Adhesion Kinase 2" was a major or minor topic of these publications.

Bar chart showing 8 publications over 6 distinct years, with a maximum of 2 publications in 2012 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2004	0	1	1
2012	2	0	2
2013	1	1	2
2014	1	0	1
2015	1	0	1

Below are the most recent publications written about "Focal Adhesion Kinase 2" by people in Profiles.

Steblyanko M, Anikeeva N, Campbell KS, Keen JH, Sykulev Y. Integrins Influence the Size and Dynamics of Signaling Microclusters in a Pyk2-dependent Manner. J Biol Chem. 2015 May 08; 290(19):11833-42.

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O-Uchi J, Jhun BS, Xu S, Hurst S, Raffaello A, Liu X, Yi B, Zhang H, Gross P, Mishra J, Ainbinder A, Kettlewell S, Smith GL, Dirksen RT, Wang W, Rizzuto R, Sheu SS. Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter. Antioxid Redox Signal. 2014 Aug 20; 21(6):863-79.

View in: PubMed
Fernandez SV, Robertson FM, Pei J, Aburto-Chumpitaz L, Mu Z, Chu K, Alpaugh RK, Huang Y, Cao Y, Ye Z, Cai KQ, Boley KM, Klein-Szanto AJ, Devarajan K, Addya S, Cristofanilli M. Inflammatory breast cancer (IBC): clues for targeted therapies. Breast Cancer Res Treat. 2013 Jul; 140(1):23-33.

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Cheng YH, Hooker RA, Nguyen K, Gerard-O'Riley R, Waning DL, Chitteti BR, Meijome TE, Chua HL, Plett AP, Orschell CM, Srour EF, Mayo LD, Pavalko FM, Bruzzaniti A, Kacena MA. Pyk2 regulates megakaryocyte-induced increases in osteoblast number and bone formation. J Bone Miner Res. 2013 Jun; 28(6):1434-45.

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Genua M, Xu SQ, Buraschi S, Peiper SC, Gomella LG, Belfiore A, Iozzo RV, Morrione A. Proline-rich tyrosine kinase 2 (Pyk2) regulates IGF-I-induced cell motility and invasion of urothelial carcinoma cells. PLoS One. 2012; 7(6):e40148.

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Kacena MA, Eleniste PP, Cheng YH, Huang S, Shivanna M, Meijome TE, Mayo LD, Bruzzaniti A. Megakaryocytes regulate expression of Pyk2 isoforms and caspase-mediated cleavage of actin in osteoblasts. J Biol Chem. 2012 May 18; 287(21):17257-17268.

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Koon N, Schneider-Stock R, Sarlomo-Rikala M, Lasota J, Smolkin M, Petroni G, Zaika A, Boltze C, Meyer F, Andersson L, Knuutila S, Miettinen M, El-Rifai W. Molecular targets for tumour progression in gastrointestinal stromal tumours. Gut. 2004 Feb; 53(2):235-40.

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Guinamard R, Okigaki M, Schlessinger J, Ravetch JV. Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nat Immunol. 2000 Jul; 1(1):31-6.

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