Focal Adhesion Kinase 1

"Focal Adhesion Kinase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.

Descriptor ID	D051417
MeSH Number(s)	D08.811.913.696.620.682.725.049.500 D12.776.744.493
Concept/Terms	Focal Adhesion Kinase 1 Focal Adhesion Kinase 1 Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK Focal Adhesion Associated Protein Tyrosine Kinase pp125FAK p125FAK Protein Protein Tyrosine Kinase 2 Endogenous Substrate pp120

Below are MeSH descriptors whose meaning is more general than "Focal Adhesion Kinase 1".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Focal Adhesion Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.049]
Focal Adhesion Kinase 1 [D08.811.913.696.620.682.725.049.500]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Phosphoproteins [D12.776.744]
Focal Adhesion Kinase 1 [D12.776.744.493]

Below are MeSH descriptors whose meaning is related to "Focal Adhesion Kinase 1".

Below are MeSH descriptors whose meaning is more specific than "Focal Adhesion Kinase 1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Focal Adhesion Kinase 1" by people in this website by year, and whether "Focal Adhesion Kinase 1" was a major or minor topic of these publications.

Bar chart showing 20 publications over 13 distinct years, with a maximum of 3 publications in 2004 and 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	0	1	1
2003	0	2	2
2004	0	3	3
2006	1	1	2
2007	0	1	1
2008	1	0	1
2009	0	1	1
2011	1	0	1
2012	1	2	3
2013	0	1	1
2016	1	1	2
2017	1	0	1

Below are the most recent publications written about "Focal Adhesion Kinase 1" by people in Profiles.

Naik MU, Naik TU, Summer R, Naik UP. Binding of CIB1 to the aIIb tail of aIIb?3 is required for FAK recruitment and activation in platelets. PLoS One. 2017; 12(5):e0176602.

View in: PubMed
DeRita RM, Zerlanko B, Singh A, Lu H, Iozzo RV, Benovic JL, Languino LR. c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes. J Cell Biochem. 2017 01; 118(1):66-73.

View in: PubMed
Anderson HJ, Galileo DS. Small-molecule inhibitors of FGFR, integrins and FAK selectively decrease L1CAM-stimulated glioblastoma cell motility and proliferation. Cell Oncol (Dordr). 2016 Jun; 39(3):229-42.

View in: PubMed
Fernandez SV, Robertson FM, Pei J, Aburto-Chumpitaz L, Mu Z, Chu K, Alpaugh RK, Huang Y, Cao Y, Ye Z, Cai KQ, Boley KM, Klein-Szanto AJ, Devarajan K, Addya S, Cristofanilli M. Inflammatory breast cancer (IBC): clues for targeted therapies. Breast Cancer Res Treat. 2013 Jul; 140(1):23-33.

View in: PubMed
Trerotola M, Li J, Alberti S, Languino LR. Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the ?1 integrin-RACK1 axis. J Cell Physiol. 2012 Nov; 227(11):3670-7.

View in: PubMed
Thom SR, Bhopale VM, Milovanova TN, Yang M, Bogush M. Thioredoxin reductase linked to cytoskeleton by focal adhesion kinase reverses actin S-nitrosylation and restores neutrophil ?(2) integrin function. J Biol Chem. 2012 Aug 31; 287(36):30346-57.

View in: PubMed
Genua M, Xu SQ, Buraschi S, Peiper SC, Gomella LG, Belfiore A, Iozzo RV, Morrione A. Proline-rich tyrosine kinase 2 (Pyk2) regulates IGF-I-induced cell motility and invasion of urothelial carcinoma cells. PLoS One. 2012; 7(6):e40148.

View in: PubMed
Yang M, Li Y, Chilukuri K, Brady OA, Boulos MI, Kappes JC, Galileo DS. L1 stimulation of human glioma cell motility correlates with FAK activation. J Neurooncol. 2011 Oct; 105(1):27-44.

View in: PubMed
Izumchenko E, Singh MK, Plotnikova OV, Tikhmyanova N, Little JL, Serebriiskii IG, Seo S, Kurokawa M, Egleston BL, Klein-Szanto A, Pugacheva EN, Hardy RR, Wolfson M, Connolly DC, Golemis EA. NEDD9 promotes oncogenic signaling in mammary tumor development. Cancer Res. 2009 Sep 15; 69(18):7198-206.

View in: PubMed
Pala D, Kapoor M, Woods A, Kennedy L, Liu S, Chen S, Bursell L, Lyons KM, Carter DE, Beier F, Leask A. Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2. J Biol Chem. 2008 Apr 04; 283(14):9239-47.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement