Smad2 Protein

"Smad2 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. It regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.

Descriptor ID	D051899
MeSH Number(s)	D12.644.360.024.334.500.200 D12.776.157.057.170.500.200 D12.776.476.024.428.500.200 D12.776.744.741.750 D12.776.930.806.500.200
Concept/Terms	Smad2 Protein Smad2 Protein MAD-Related 2 Protein MAD Related 2 Protein MADR2 Protein

Below are MeSH descriptors whose meaning is more general than "Smad2 Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
Smad Proteins [D12.644.360.024.334]
Smad Proteins, Receptor-Regulated [D12.644.360.024.334.500]
Smad2 Protein [D12.644.360.024.334.500.200]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
Smad Proteins [D12.776.157.057.170]
Smad Proteins, Receptor-Regulated [D12.776.157.057.170.500]
Smad2 Protein [D12.776.157.057.170.500.200]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
Smad Proteins [D12.776.476.024.428]
Smad Proteins, Receptor-Regulated [D12.776.476.024.428.500]
Smad2 Protein [D12.776.476.024.428.500.200]
Phosphoproteins [D12.776.744]
Smad Proteins, Receptor-Regulated [D12.776.744.741]
Smad2 Protein [D12.776.744.741.750]
Transcription Factors [D12.776.930]
Smad Proteins [D12.776.930.806]
Smad Proteins, Receptor-Regulated [D12.776.930.806.500]
Smad2 Protein [D12.776.930.806.500.200]

Below are MeSH descriptors whose meaning is related to "Smad2 Protein".

Below are MeSH descriptors whose meaning is more specific than "Smad2 Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Smad2 Protein" by people in this website by year, and whether "Smad2 Protein" was a major or minor topic of these publications.

Bar chart showing 23 publications over 16 distinct years, with a maximum of 3 publications in 2013 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2002	0	1	1
2003	0	1	1
2006	0	2	2
2007	1	0	1
2008	0	1	1
2010	0	2	2
2011	0	1	1
2012	1	0	1
2013	0	3	3
2014	0	3	3
2015	0	1	1
2016	1	1	2
2017	0	1	1
2018	0	1	1
2022	0	1	1

Below are the most recent publications written about "Smad2 Protein" by people in Profiles.

Bertrand-Chapel A, Caligaris C, Fenouil T, Savary C, Aires S, Martel S, Huched? P, Chassot C, Chauvet V, Cardot-Ruffino V, Morel AP, Subtil F, Mohkam K, Mabrut JY, Tonon L, Viari A, Cassier P, Hervieu V, Castets M, Mauviel A, Sentis S, Bartholin L. SMAD2/3 mediate oncogenic effects of TGF-? in the absence of SMAD4. Commun Biol. 2022 10 07; 5(1):1068.

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Pons M, Koniaris LG, Moe SM, Gutierrez JC, Esquela-Kerscher A, Zimmers TA. GDF11 induces kidney fibrosis, renal cell epithelial-to-mesenchymal transition, and kidney dysfunction and failure. Surgery. 2018 08; 164(2):262-273.

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Zhang Y, O'Leary MN, Peri S, Wang M, Zha J, Melov S, Kappes DJ, Feng Q, Rhodes J, Amieux PS, Morris DR, Kennedy BK, Wiest DL. Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing. Cell Rep. 2017 01 10; 18(2):545-556.

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Wang W, Song B, Anbarchian T, Shirazyan A, Sadik JE, Lyons KM. Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate. PLoS Genet. 2016 Oct; 12(10):e1006352.

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Jin X, Ren S, Macarak E, Rosenbloom J. Pathobiological mechanisms of peritoneal adhesions: The mesenchymal transition of rat peritoneal mesothelial cells induced by TGF-?1 and IL-6 requires activation of Erk1/2 and Smad2 linker region phosphorylation. Matrix Biol. 2016 04; 51:55-64.

View in: PubMed
Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M, McGrath JA, Cerio R, Kivisaari A, K?h?ri VM, Hodivala-Dilke K, Brennan CH, Chen M, Marshall JF, O'Toole EA. Suppression of TGF? and Angiogenesis by Type VII Collagen in Cutaneous SCC. J Natl Cancer Inst. 2016 Jan; 108(1).

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Khan S, Joyce J, Margulies KB, Tsuda T. Enhanced bioactive myocardial transforming growth factor-? in advanced human heart failure. Circ J. 2014; 78(11):2711-8.

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Stephen TL, Rutkowski MR, Allegrezza MJ, Perales-Puchalt A, Tesone AJ, Svoronos N, Nguyen JM, Sarmin F, Borowsky ME, Tchou J, Conejo-Garcia JR. Transforming growth factor ?-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression. Immunity. 2014 Sep 18; 41(3):427-439.

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Kern G, Mair SM, Noppert SJ, Jennings P, Schramek H, Rudnicki M, Mueller GA, Mayer G, Koppelstaetter C. Tacrolimus increases Nox4 expression in human renal fibroblasts and induces fibrosis-related genes by aberrant TGF-beta receptor signalling. PLoS One. 2014; 9(5):e96377.

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Kang MH, Oh DJ, Kang JH, Rhee DJ. Regulation of SPARC by transforming growth factor ?2 in human trabecular meshwork. Invest Ophthalmol Vis Sci. 2013 Apr 05; 54(4):2523-32.

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