"Myostatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A growth differentiation factor that is a potent inhibitor of SKELETAL MUSCLE growth. It may play a role in the regulation of MYOGENESIS and in muscle maintenance during adulthood.
| Descriptor ID |
D055435
|
| MeSH Number(s) |
D12.644.276.954.300.925 D12.776.467.942.300.925 D23.529.942.300.925
|
| Concept/Terms |
Myostatin- Myostatin
- Growth Differentiation Factor 8
- GDF-8
|
Below are MeSH descriptors whose meaning is more general than "Myostatin".
Below are MeSH descriptors whose meaning is more specific than "Myostatin".
This graph shows the total number of publications written about "Myostatin" by people in this website by year, and whether "Myostatin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 2 | 0 | 2 |
| 2014 | 1 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
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Below are the most recent publications written about "Myostatin" by people in Profiles.
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Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M. Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation. 2016 Sep 13; 134(11):817-32.
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Schafer MJ, Atkinson EJ, Vanderboom PM, Kotajarvi B, White TA, Moore MM, Bruce CJ, Greason KL, Suri RM, Khosla S, Miller JD, Bergen HR, LeBrasseur NK. Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease. Cell Metab. 2016 Jun 14; 23(6):1207-1215.
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Padhi D, Higano CS, Shore ND, Sieber P, Rasmussen E, Smith MR. Pharmacological inhibition of myostatin and changes in lean body mass and lower extremity muscle size in patients receiving androgen deprivation therapy for prostate cancer. J Clin Endocrinol Metab. 2014 Oct; 99(10):E1967-75.
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Benny Klimek ME, Aydogdu T, Link MJ, Pons M, Koniaris LG, Zimmers TA. Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia. Biochem Biophys Res Commun. 2010 Jan 15; 391(3):1548-54.
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Karlowatz RJ, Scharhag J, Rahnenf?hrer J, Schneider U, Jakob E, Kindermann W, Zang KD. Polymorphisms in the IGF1 signalling pathway including the myostatin gene are associated with left ventricular mass in male athletes. Br J Sports Med. 2011 Jan; 45(1):36-41.
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Sengle G, Ono RN, Lyons KM, B?chinger HP, Sakai LY. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol. 2008 Sep 12; 381(4):1025-39.
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Zimmers TA, Davies MV, Koniaris LG, Haynes P, Esquela AF, Tomkinson KN, McPherron AC, Wolfman NM, Lee SJ. Induction of cachexia in mice by systemically administered myostatin. Science. 2002 May 24; 296(5572):1486-8.