SMN Complex Proteins

"SMN Complex Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A complex of proteins that assemble the SNRNP CORE PROTEINS into a core structure that surrounds a highly conserved RNA sequence found in SMALL NUCLEAR RNA. They are found localized in the GEMINI OF COILED BODIES and in the CYTOPLASM. The SMN complex is named after the Survival of Motor Neuron Complex Protein 1, which is a critical component of the complex.

Descriptor ID	D055532
MeSH Number(s)	D12.776.157.725.875 D12.776.580.922 D12.776.664.962.875
Concept/Terms	SMN Complex Proteins SMN Complex Proteins Gemin Proteins Survival of Motor Neuron Complex Proteins Gem-Associated Proteins Gem Associated Proteins Gemin4 Protein Gemin4 Protein Gemin-4 Protein Gemin 4 Protein Component of Gems 4 Protein SMN Complex SMN Complex Survival of Motor Neuron Complex Gemin6 Protein Gemin6 Protein Gemin-6 Protein Gemin 6 Protein Gemin7 Protein Gemin7 Protein Protein, Gemin7 Gemin-7 Protein Gemin 7 Protein Protein, Gemin-7 Gemin8 Protein Gemin8 Protein Gemin-8 Protein Gemin 8 Protein FAM51A1 Protein Gemin2 Protein Gemin2 Protein Survival of Motor Neuron Protein-Interacting Protein 1 Survival of Motor Neuron Protein Interacting Protein 1 Gemin-2 Protein Gemin 2 Protein Gemin5 Protein Gemin5 Protein Gemin-5 Protein Gemin 5 Protein

Below are MeSH descriptors whose meaning is more general than "SMN Complex Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
RNA-Binding Proteins [D12.776.157.725]
SMN Complex Proteins [D12.776.157.725.875]
Molecular Chaperones [D12.776.580]
SMN Complex Proteins [D12.776.580.922]
Nucleoproteins [D12.776.664]
RNA-Binding Proteins [D12.776.664.962]
SMN Complex Proteins [D12.776.664.962.875]

Below are MeSH descriptors whose meaning is more specific than "SMN Complex Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "SMN Complex Proteins" by people in this website by year, and whether "SMN Complex Proteins" was a major or minor topic of these publications.

Bar chart showing 10 publications over 5 distinct years, with a maximum of 5 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	0	1	1
2007	0	5	5
2008	1	1	2
2011	1	0	1
2014	1	0	1

Below are the most recent publications written about "SMN Complex Proteins" by people in Profiles.

Butchbach ME, Singh J, Gurney ME, Burghes AH. The effect of diet on the protective action of D156844 observed in spinal muscular atrophy mice. Exp Neurol. 2014 Jun; 256:1-6.

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Wu CY, Curtis A, Choi YS, Maeda M, Xu MJ, Berg A, Joneja U, Mason RW, Lee KH, Wang W. Identification of the phosphorylation sites in the survival motor neuron protein by protein kinase A. Biochim Biophys Acta. 2011 Sep; 1814(9):1134-9.

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Mattis VB, Butchbach ME, Lorson CL. Detection of human survival motor neuron (SMN) protein in mice containing the SMN2 transgene: applicability to preclinical therapy development for spinal muscular atrophy. J Neurosci Methods. 2008 Oct 30; 175(1):36-43.

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Thurmond J, Butchbach ME, Palomo M, Pease B, Rao M, Bedell L, Keyvan M, Pai G, Mishra R, Haraldsson M, Andresson T, Bragason G, Thosteinsdottir M, Bjornsson JM, Coovert DD, Burghes AH, Gurney ME, Singh J. Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy. J Med Chem. 2008 Feb 14; 51(3):449-69.

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Novoyatleva T, Heinrich B, Tang Y, Benderska N, Butchbach ME, Lorson CL, Lorson MA, Ben-Dov C, Fehlbaum P, Bracco L, Burghes AH, Bollen M, Stamm S. Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing. Hum Mol Genet. 2008 Jan 01; 17(1):52-70.

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Gabanella F, Butchbach ME, Saieva L, Carissimi C, Burghes AH, Pellizzoni L. Ribonucleoprotein assembly defects correlate with spinal muscular atrophy severity and preferentially affect a subset of spliceosomal snRNPs. PLoS One. 2007 Sep 26; 2(9):e921.

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Shanmugarajan S, Swoboda KJ, Iannaccone ST, Ries WL, Maria BL, Reddy SV. Congenital bone fractures in spinal muscular atrophy: functional role for SMN protein in bone remodeling. J Child Neurol. 2007 Aug; 22(8):967-73.

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G?mez-Curet I, Robinson KG, Funanage VL, Crawford TO, Scavina M, Wang W. Robust quantification of the SMN gene copy number by real-time TaqMan PCR. Neurogenetics. 2007 Nov; 8(4):271-8.

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Butchbach ME, Edwards JD, Burghes AH. Abnormal motor phenotype in the SMNDelta7 mouse model of spinal muscular atrophy. Neurobiol Dis. 2007 Aug; 27(2):207-19.

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Le TT, Pham LT, Butchbach ME, Zhang HL, Monani UR, Coovert DD, Gavrilina TO, Xing L, Bassell GJ, Burghes AH. SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN. Hum Mol Genet. 2005 Mar 15; 14(6):845-57.

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