Thomas Jefferson University

Yuri Sykulev

TitleFaculty
InstitutionThomas Jefferson University
DepartmentMedical Oncology - Thomas Jefferson University
Address951 Locust Street
Philadelphia PA 19107
Phone2155034530
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Maskalenko NA, Zahroun S, Tsygankova O, Anikeeva N, Sykulev Y, Campbell KS. The Fc?RIIIA (CD16) L48-H/R Polymorphism Enhances NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity by Promoting Serial Killing. Cancer Immunol Res. 2025 Mar 04; 13(3):417-429. PMID: 39666369.
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    2. Golovin AV, Panteleev S, Zlobin AS, Anikeeva N, Smirnov I, Gabibov A, Sykulev Y. The role of peptide conformation presented by MHC in the induction of TCR triggering. Biophys J. 2025 Apr 01; 124(7):1073-1084. PMID: 39921257.
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    3. Sykulev Y. Factors contributing to the potency of CD8+ T cells. Trends Immunol. 2023 09; 44(9):693-700. PMID: 37558570.
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    4. Anikeeva N, Steblyanko M, Kuri-Cervantes L, Buggert M, Betts MR, Sykulev Y. The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection. Nat Commun. 2022 10 28; 13(1):6436. PMID: 36307445.
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    5. Anikeeva N, Panteleev S, Mazzanti NW, Terai M, Sato T, Sykulev Y. Efficient killing of tumor cells by CAR-T cells requires greater number of engaged CARs than TCRs. J Biol Chem. 2021 09; 297(3):101033. PMID: 34371020.
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    6. Maskalenko N, Nath S, Ramakrishnan A, Anikeeva N, Sykulev Y, Poenie M. The DISC1-Girdin complex - a missing link in signaling to the T cell cytoskeleton. J Cell Sci. 2020 07 06; 133(13). PMID: 32482796.
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    7. Mamedov A, Vorobyeva N, Filimonova I, Zakharova M, Kiselev I, Bashinskaya V, Baulina N, Boyko A, Favorov A, Kulakova O, Ziganshin R, Smirnov I, Poroshina A, Shilovskiy I, Khaitov M, Sykulev Y, Favorova O, Vlassov V, Gabibov A, Belogurov A. Protective Allele for Multiple Sclerosis HLA-DRB1*01:01 Provides Kinetic Discrimination of Myelin and Exogenous Antigenic Peptides. Front Immunol. 2019; 10:3088. PMID: 32010139.
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    8. Anikeeva N, Fischer NO, Blanchette CD, Sykulev Y. Extent of MHC Clustering Regulates Selectivity and Effectiveness of T Cell Responses. J Immunol. 2019 01 15; 202(2):591-597. PMID: 30541879.
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    9. Steblyanko M, Anikeeva N, Buggert M, Betts MR, Sykulev Y. Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue. J Vis Exp. 2018 07 30; (137). PMID: 30102290.
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    10. Buggert M, Nguyen S, McLane LM, Steblyanko M, Anikeeva N, Paquin-Proulx D, Del Rio Estrada PM, Ablanedo-Terrazas Y, Noyan K, Reuter MA, Demers K, Sandberg JK, Eller MA, Streeck H, Jansson M, Nowak P, S?nnerborg A, Canaday DH, Naji A, Wherry EJ, Robb ML, Deeks SG, Reyes-Teran G, Sykulev Y, Karlsson AC, Betts MR. Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease. PLoS Pathog. 2018 04; 14(4):e1006973. PMID: 29652923.
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    11. Anikeeva N, Grosso D, Flomenberg N, Sykulev Y. Evaluating frequency and quality of pathogen-specific T cells. Nat Commun. 2016 10 27; 7:13264. PMID: 27786275.
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    12. Steblyanko M, Anikeeva N, Campbell KS, Keen JH, Sykulev Y. Integrins Influence the Size and Dynamics of Signaling Microclusters in a Pyk2-dependent Manner. J Biol Chem. 2015 May 08; 290(19):11833-42. PMID: 25778396.
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    13. Kranz DM, Sykulev Y. Herman N. Eisen: Mentor to many. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):1650-1. PMID: 25617368.
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    14. Anikeeva N, Sykulev Y, Delikatny EJ, Popov AV. Core-based lipid nanoparticles as a nanoplatform for delivery of near-infrared fluorescent imaging agents. Am J Nucl Med Mol Imaging. 2014; 4(6):507-24. PMID: 25250201.
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    15. Anikeeva N, Steblyanko M, Fayngerts S, Kopylova N, Marshall DJ, Powers GD, Sato T, Campbell KS, Sykulev Y. Integrin receptors on tumor cells facilitate NK cell-mediated antibody-dependent cytotoxicity. Eur J Immunol. 2014 Aug; 44(8):2331-9. PMID: 24810893.
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    16. Anikeeva N, Gakamsky D, Sch?ller J, Sykulev Y. Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling. PLoS One. 2012; 7(8):e41466. PMID: 22870225.
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    17. Yashin DV, Dukhanina EA, Kabanova OD, Romanova EA, Lukyanova TI, Sheludchenkov AA, Sykulev YK, Gnuchev NV, Sashchenko LP. The mechanisms of inactivation of the Tag7-Hsp70 cytotoxic complex. Dokl Biol Sci. 2012 Jan-Feb; 442:62-3. PMID: 22427227.
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    18. Lisitsyn NA, Bukurova YA, Nikitina IG, Krasnov GS, Sykulev Y, Beresten SF. Enteric alpha defensins in norm and pathology. Ann Clin Microbiol Antimicrob. 2012 Jan 11; 11:1. PMID: 22236533.
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    19. Anikeeva N, Sykulev Y. Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes. Immunol Res. 2011 Dec; 51(2-3):183-94. PMID: 22058021.
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    20. Sykulev Y. T cell receptor signaling kinetics takes the stage. Sci Signal. 2010 Dec 21; 3(153):pe50. PMID: 21177491.
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    21. Sykulev Y. Changing separating distances between immune receptors as a sensitive mechanism regulating T-cell activation. Self Nonself. 2010 Jan; 1(1):67-68. PMID: 21318086.
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    22. Mareeva T, Wanjalla C, Schnell MJ, Sykulev Y. A novel composite immunotoxin that suppresses rabies virus production by the infected cells. J Immunol Methods. 2010 Feb 28; 353(1-2):78-86. PMID: 19932697.
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    23. Beal AM, Anikeeva N, Varma R, Cameron TO, Vasiliver-Shamis G, Norris PJ, Dustin ML, Sykulev Y. Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain. Immunity. 2009 Oct 16; 31(4):632-42. PMID: 19833088.
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    24. Anikeeva N, Mareeva T, Liu W, Sykulev Y. Can oligomeric T-cell receptor be used as a tool to detect viral peptide epitopes on infected cells? Clin Immunol. 2009 Jan; 130(1):98-109. PMID: 18845488.
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    25. Beal AM, Anikeeva N, Varma R, Cameron TO, Norris PJ, Dustin ML, Sykulev Y. Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL. J Immunol. 2008 Oct 01; 181(7):4815-24. PMID: 18802085.
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    26. Mareeva T, Martinez-Hackert E, Sykulev Y. How a T cell receptor-like antibody recognizes major histocompatibility complex-bound peptide. J Biol Chem. 2008 Oct 24; 283(43):29053-9. PMID: 18703505.
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    27. Tsatsanis C, Vaporidi K, Zacharioudaki V, Androulidaki A, Sykulev Y, Margioris AN, Tsichlis PN. Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):2987-92. PMID: 18287049.
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    28. Anikeeva N, Lebedeva T, Clapp AR, Goldman ER, Dustin ML, Mattoussi H, Sykulev Y. Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16846-51. PMID: 17077145.
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    29. Martinez-Hackert E, Anikeeva N, Kalams SA, Walker BD, Hendrickson WA, Sykulev Y. Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes. J Biol Chem. 2006 Jul 21; 281(29):20205-12. PMID: 16702212.
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    30. Norris PJ, Stone JD, Anikeeva N, Heitman JW, Wilson IC, Hirschkorn DF, Clark MJ, Moffett HF, Cameron TO, Sykulev Y, Stern LJ, Walker BD. Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope. Mol Immunol. 2006 Mar; 43(9):1349-57. PMID: 16216327.
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    31. Lebedeva T, Dustin ML, Sykulev Y. ICAM-1 co-stimulates target cells to facilitate antigen presentation. Curr Opin Immunol. 2005 Jun; 17(3):251-8. PMID: 15886114.
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    32. Anikeeva N, Somersalo K, Sims TN, Thomas VK, Dustin ML, Sykulev Y. Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 2005 May 03; 102(18):6437-42. PMID: 15851656.
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    33. Lebedeva T, Anikeeva N, Kalams SA, Walker BD, Gaidarov I, Keen JH, Sykulev Y. Major histocompatibility complex class I-intercellular adhesion molecule-1 association on the surface of target cells: implications for antigen presentation to cytotoxic T lymphocytes. Immunology. 2004 Dec; 113(4):460-71. PMID: 15554924.
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    34. Mareeva T, Lebedeva T, Anikeeva N, Manser T, Sykulev Y. Antibody specific for the peptide.major histocompatibility complex. Is it T cell receptor-like? J Biol Chem. 2004 Oct 22; 279(43):44243-9. PMID: 15302863.
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    35. Somersalo K, Anikeeva N, Sims TN, Thomas VK, Strong RK, Spies T, Lebedeva T, Sykulev Y, Dustin ML. Cytotoxic T lymphocytes form an antigen-independent ring junction. J Clin Invest. 2004 Jan; 113(1):49-57. PMID: 14702108.
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    36. Anikeeva N, Lebedeva T, Sumaroka M, Kalams SA, Sykulev Y. Soluble HIV-specific T cell receptor: expression, purification and analysis of the specificity. J Immunol Methods. 2003 Jun 01; 277(1-2):75-86. PMID: 12799041.
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    37. Anikeeva N, Lebedeva T, Krogsgaard M, Tetin SY, Martinez-Hackert E, Kalams SA, Davis MM, Sykulev Y. Distinct molecular mechanisms account for the specificity of two different T-cell receptors. Biochemistry. 2003 Apr 29; 42(16):4709-16. PMID: 12705834.
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    38. Das S, Lin JH, Papamatheakis J, Sykulev Y, Tsichlis PN. Differential splicing generates Tvl-1/RFXANK isoforms with different functions. J Biol Chem. 2002 Nov 22; 277(47):45172-80. PMID: 12215433.
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    39. Sykulev YK, Cohen RJ, Eisen HN. Particle counting by flow cytometry can determine intrinsic equilibrium constants for antibody-ligand interactions in solution. Mol Immunol. 1993 Jan; 30(1):101-4. PMID: 8417367.
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    40. Sykulev YK, Sherman DA, Cohen RJ, Eisen HN. Quantitation of reversible binding by particle counting: hapten-antibody interaction as a model system. Proc Natl Acad Sci U S A. 1992 May 15; 89(10):4703-7. PMID: 1584807.
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    41. Sykulev YK, Yeronina TV, Aleshkin VA, Ostreiko KK. Galactose-containing epitopes on the surface of IgG model immune complexes are accessible for specific binding with the high molecular weight ligand, Ricinus agglutinin, in solution-light-scattering studies. Mol Immunol. 1991 Oct; 28(10):1105-11. PMID: 1717838.
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    42. Sykulev YK, Nezlin RS. Spin labeling of immunoglobulin M and E carbohydrates. Immunol Lett. 1982 Sep; 5(3):121-6. PMID: 6295927.
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    43. Nezlin RS, Sykulev YK. Structural studies of immunoglobulins spin-labeled at the carbohydrate moiety. Mol Immunol. 1982 Mar; 19(3):347-56. PMID: 6285180.
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    44. Timofeev VP, Dudich IV, Sykulev YK, Nezlin RS, Franek F. Slow conformational change in anti-dansyl antibody as a consequence of hapten binding: demonstration by ESR spectra. FEBS Lett. 1979 Jun 01; 102(1):103-6. PMID: 222612.
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    45. Sykulev YK, Timofeev VP, Nezlin RS, Misharin AY, Franek F. Spin-label study of segmental flexibility of anti-hapten antibodies. Precipitating pig anti-Dnp antibody is more flexible than non-precipitating. FEBS Lett. 1979 May 01; 101(1):27-30. PMID: 221252.
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    46. Timofeev VP, Dudich IV, Sykulev YK, Nezlin RS. Rotational correlation times of IgG and its fragments spin-labeled at carbohydrate or protein moieties. Spatially fixed position of the Fc carbohydrate. FEBS Lett. 1978 May 15; 89(2):191-5. PMID: 207572.
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    47. Nezlin RS, Timofeev VP, Sykulev YK, Zurabyan SE. Spin-labeling of immunoglobulin carbohydrates. Immunochemistry. 1978 Mar; 15(3):143-4. PMID: 205501.
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