Ubiquitin Thiolesterase

"Ubiquitin Thiolesterase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A thioester hydrolase which acts on esters formed between thiols such as DITHIOTHREITOL or GLUTATHIONE and the C-terminal glycine residue of UBIQUITIN.

Descriptor ID	D043222
MeSH Number(s)	D08.811.037.500 D08.811.277.352.897.850 D12.776.637.937
Concept/Terms	Ubiquitin Thiolesterase Ubiquitin Thiolesterase Thiolesterase, Ubiquitin Ubiquitin C-Terminal Hydrolase C-Terminal Hydrolase, Ubiquitin Hydrolase, Ubiquitin C-Terminal Ubiquitin C Terminal Hydrolase Ubiquitin Carboxy-Terminal Hydrolase Carboxy-Terminal Hydrolase, Ubiquitin Hydrolase, Ubiquitin Carboxy-Terminal Ubiquitin Carboxy Terminal Hydrolase Ubiquitin C-Terminal Esterase C-Terminal Esterase, Ubiquitin Esterase, Ubiquitin C-Terminal Ubiquitin C Terminal Esterase Ubiquitin Carboxy-Terminal Esterase Carboxy-Terminal Esterase, Ubiquitin Esterase, Ubiquitin Carboxy-Terminal Ubiquitin Carboxy Terminal Esterase Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 Ubiquitin Carboxyl Terminal Hydrolase Isozyme L1 Parkinson Disease 5 Protein PARK5 Protein Neuron Cytoplasmic Protein 9.5 UCHL1 Protein Uch-L1 Protein Uch L1 Protein

Below are MeSH descriptors whose meaning is more general than "Ubiquitin Thiolesterase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Deubiquitinating Enzymes [D08.811.037]
Ubiquitin Thiolesterase [D08.811.037.500]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Thiolester Hydrolases [D08.811.277.352.897]
Ubiquitin Thiolesterase [D08.811.277.352.897.850]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Parkinson Disease Associated Proteins [D12.776.637]
Ubiquitin Thiolesterase [D12.776.637.937]

Below are MeSH descriptors whose meaning is related to "Ubiquitin Thiolesterase".

Below are MeSH descriptors whose meaning is more specific than "Ubiquitin Thiolesterase".

Ubiquitin Thiolesterase
Ubiquitin-Specific Peptidase 7

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ubiquitin Thiolesterase" by people in this website by year, and whether "Ubiquitin Thiolesterase" was a major or minor topic of these publications.

Bar chart showing 40 publications over 14 distinct years, with a maximum of 7 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	0	1
2005	1	0	1
2008	0	3	3
2012	0	1	1
2013	1	3	4
2015	1	1	2
2016	1	0	1
2017	2	0	2
2018	2	2	4
2019	3	2	5
2020	1	1	2
2021	4	3	7
2022	2	1	3
2024	3	1	4

Below are the most recent publications written about "Ubiquitin Thiolesterase" by people in Profiles.

Monda SM, Carney BW, May AM, Gulati S, Salami SS, Chandrasekar T, Keller ET, Huebner NA, Palapattu GS, Dall'Era MA. Differences?in mutations across tumour sizes in clear-cell renal cell carcinoma. BJU Int. 2025 Feb; 135(2):269-278.

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Zeng L, Zhu Y, Cui X, Chi J, Uddin A, Zhou Z, Song X, Dai M, Cristofanilli M, Kalinsky K, Wan Y. Tuning Immune-Cold Tumor by Suppressing USP10/B7-H4 Proteolytic Axis Reinvigorates Therapeutic Efficacy of ADCs. Adv Sci (Weinh). 2024 10; 11(40):e2400757.

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Chua V, Lopez-Anton M, Baqai U, Purwin TJ, Haj JI, Waltrich FJ, Trachtenberg I, Luo K, Tudi R, Jeon A, Han A, Chervoneva I, Davies MA, Aguirre-Ghiso JA, Sato T, Aplin AE. Slow proliferation of BAP1-deficient uveal melanoma cells is associated with reduced S6 signaling and resistance to nutrient stress. Sci Signal. 2024 06 11; 17(840):eadn8376.

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Eiger-Moscovich M, Shields CL, Eagle RC, Milman T. BRCA-associated protein1 (BAP1) immunohistochemical stain reliability in postbrachytherapy uveal melanoma enucleation specimens. Indian J Ophthalmol. 2024 05 01; 72(Suppl 3):S459-S467.

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Langbein LE, El Hajjar R, He S, Sementino E, Zhong Z, Jiang W, Leiby BE, Li L, Uzzo RG, Testa JR, Yang H. BAP1 maintains HIF-dependent interferon beta induction to suppress tumor growth in clear cell renal cell carcinoma. Cancer Lett. 2022 10 28; 547:215885.

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Baqai U, Purwin TJ, Bechtel N, Chua V, Han A, Hartsough EJ, Kuznetsoff JN, Harbour JW, Aplin AE. Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma. Mol Cancer Res. 2022 08 05; 20(8):1260-1271.

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Han A, Chua V, Baqai U, Purwin TJ, Bechtel N, Hunter E, Tiago M, Seifert E, Speicher DW, Schug ZT, Harbour JW, Aplin AE. Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma. Oncogene. 2022 Feb; 41(8):1129-1139.

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Hu ZI, Miettinen M, Quezado M, Lebensohn AP, Aldape K, Agra M, Wagner C, Mallory Y, Hassan R, Ghafoor A. Meningiomas in Patients With Malignant Pleural Mesothelioma Harboring Germline BAP1 Mutations. J Thorac Oncol. 2022 03; 17(3):461-466.

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Chua V, Han A, Bechtel N, Purwin TJ, Hunter E, Liao C, Harbour JW, Aplin AE. The AMP-dependent kinase pathway is upregulated in BAP1 mutant uveal melanoma. Pigment Cell Melanoma Res. 2022 01; 35(1):78-87.

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Stanek TJ, Gennaro VJ, Tracewell MA, Di Marcantonio D, Pauley KL, Butt S, McNair C, Wang F, Kossenkov AV, Knudsen KE, Butt T, Sykes SM, McMahon SB. The SAGA complex regulates early steps in transcription via its deubiquitylase module subunit USP22. EMBO J. 2021 08 16; 40(16):e102509.

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