Kelvin H Lee

TitleGore Professor of Chemical Engineering
InstitutionUniversity of Delaware
DepartmentChemical and Biomolecular Engineering
Address15 Innovation Way
Newark DE 19716
Phone302-831-0344
vCardDownload vCard
    Other Positions
    TitleDirector
    InstitutionUniversity of Delaware
    DepartmentDelaware Biotechnology Institute (DBI)

    TitleProfessor
    InstitutionUniversity of Delaware
    DepartmentDelaware Biotechnology Institute (DBI)


    Collapse Research 
    Collapse research activities and funding
    R01MH059926     (LEE, KELVIN H)Apr 1, 2001 - Mar 31, 2007
    NIH
    Proteome Markers for Alzheimer's Disease Diagnosis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Singh SK, Lee KH. Characterization of Monoclonal Antibody Glycan Heterogeneity Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry. Front Bioeng Biotechnol. 2021; 9:805788. PMID: 35087805.
      Citations:    
    2. Spahn PN, Zhang X, Hu Q, Lu H, Hamaker NK, Hefzi H, Li S, Kuo CC, Huang Y, Lee JC, Davis AJ, Ly P, Lee KH, Lewis NE. Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells. Biotechnol Bioeng. 2022 03; 119(3):963-982. PMID: 34953085.
      Citations:    
    3. MacDonald ML, Lee KH. EvalDNA: a machine learning-based tool for the comprehensive evaluation of mammalian genome assembly quality. BMC Bioinformatics. 2021 Nov 27; 22(1):570. PMID: 34837948.
      Citations:    
    4. Nmagu D, Singh SK, Lee KH. Creation of monoclonal antibody expressing CHO cell lines grown with sodium butyrate and characterization of resulting antibody glycosylation. Methods Enzymol. 2021; 660:267-295. PMID: 34742393.
      Citations:    
    5. Green EA, Lee KH. Analytical methods to characterize recombinant adeno-associated virus vectors and the benefit of standardization and reference materials. Curr Opin Biotechnol. 2021 Oct; 71:65-76. PMID: 34273809.
      Citations:    
    6. Klaubert SR, Chitwood DG, Dahodwala H, Williamson M, Kasper R, Lee KH, Harcum SW. Method to transfer Chinese hamster ovary (CHO) batch shake flask experiments to large-scale, computer-controlled fed-batch bioreactors. Methods Enzymol. 2021; 660:297-320. PMID: 34742394.
      Citations:    
    7. MacDonald ML, Polson SW, Lee KH. k-mer-Based Metagenomics Tools Provide a Fast and Sensitive Approach for the Detection of Viral Contaminants in Biopharmaceutical and Vaccine Manufacturing Applications Using Next-Generation Sequencing. mSphere. 2021 Apr 21; 6(2). PMID: 33883263.
      Citations:    
    8. Baik JY, Han HJ, Lee KH. DNA Double-Strand Breaks Affect Chromosomal Rearrangements during Methotrexate-Mediated Gene Amplification in Chinese Hamster Ovary Cells. Pharmaceutics. 2021 Mar 12; 13(3). PMID: 33809068.
      Citations:    
    9. Hilliard W, Lee KH. Systematic identification of safe harbor regions in the CHO genome through a comprehensive epigenome analysis. Biotechnol Bioeng. 2020 Oct 13. PMID: 33049068.
      Citations:    
    10. Ruano-Salguero JS, Lee KH. Adsorptive-Mediated Endocytosis of Sulfo-Cy5-Labeled IgG Causes Aberrant IgG Processing by Brain Endothelial-Like Cells. Mol Pharm. 2020 11 02; 17(11):4280-4285. PMID: 32986439.
      Citations:    
    11. Luo Y, Lovelett RJ, Price JV, Radhakrishnan D, Barnthouse K, Hu P, Schaefer E, Cunningham J, Lee KH, Shivappa RB, Ogunnaike BA. Modeling the Effect of Amino Acids and Copper on Monoclonal Antibody Productivity and Glycosylation: A Modular Approach. Biotechnol J. 2020 Sep 01; e2000261. PMID: 32875683.
      Citations:    
    12. Saylor J, Mehta V, Choe LH, Mantle J, Szkodny A, Kingham B, Taylor L, Meadows A, Flynn C, Lee KH, Joseph A. Rapid Development and Validation of a Novel Laboratory-Derived Test for the Detection of SARS-CoV-2. Dela J Public Health. 2020 Jul; 6(2):10-15. PMID: 34467100.
      Citations:    
    13. Lee KH, Mantle JL. Summary from Advanced Manufacturing Technology Workshop held at 6th Accelerating Biopharmaceutical Development Meeting. PDA J Pharm Sci Technol. 2020 Jun 15. PMID: 32540863.
      Citations:    
    14. Hamaker NK, Lee KH. A Site-Specific Integration Reporter System That Enables Rapid Evaluation of CRISPR/Cas9-Mediated Genome Editing Strategies in CHO Cells. Biotechnol J. 2020 Jun 04; e2000057. PMID: 32500600.
      Citations:    
    15. Mantle JL, Lee KH. NIIMBL-facilitated Active Listening Meeting between industry and FDA identifies common challenges for adoption of new biopharmaceutical manufacturing technologies. PDA J Pharm Sci Technol. 2020 May 28. PMID: 32467179.
      Citations:    
    16. Hilliard W, MacDonald ML, Lee KH. Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome. Biotechnol Bioeng. 2020 May 15. PMID: 32410221.
      Citations:    
    17. Ruano-Salguero JS, Lee KH. Antibody transcytosis across brain endothelial-like cells occurs nonspecifically and independent of FcRn. Sci Rep. 2020 Feb 28; 10(1):3685. PMID: 32111886.
      Citations:    
    18. De Leoz MLA, Duewer DL, Fung A, Liu L, Yau HK, Potter O, Staples GO, Furuki K, Frenkel R, Hu Y, Sosic Z, Zhang P, Altmann F, Gru Nwald-Grube C, Shao C, Zaia J, Evers W, Pengelley S, Suckau D, Wiechmann A, Resemann A, Jabs W, Beck A, Froehlich JW, Huang C, Li Y, Liu Y, Sun S, Wang Y, Seo Y, An HJ, Reichardt NC, Ruiz JE, Archer-Hartmann S, Azadi P, Bell L, Lakos Z, An Y, Cipollo JF, Pucic-Bakovic M, Štambuk J, Lauc G, Li X, Wang PG, Bock A, Hennig R, Rapp E, Creskey M, Cyr TD, Nakano M, Sugiyama T, Leung PA, Link-Lenczowski P, Jaworek J, Yang S, Zhang H, Kelly T, Klapoetke S, Cao R, Kim JY, Lee HK, Lee JY, Yoo JS, Kim SR, Suh SK, de Haan N, Falck D, Lageveen-Kammeijer GSM, Wuhrer M, Emery RJ, Kozak RP, Liew LP, Royle L, Urbanowicz PA, Packer NH, Song X, Everest-Dass A, Lattová E, Cajic S, Alagesan K, Kolarich D, Kasali T, Lindo V, Chen Y, Goswami K, Gau B, Amunugama R, Jones R, Stroop CJM, Kato K, Yagi H, Kondo S, Yuen CT, Harazono A, Shi X, Magnelli PE, Kasper BT, Mahal L, Harvey DJ, O'Flaherty R, Rudd PM, Saldova R, Hecht ES, Muddiman DC, Kang J, Bhoskar P, Menard D, Saati A, Merle C, Mast S, Tep S, Truong J, Nishikaze T, Sekiya S, Shafer A, Funaoka S, Toyoda M, de Vreugd P, Caron C, Pradhan P, Tan NC, Mechref Y, Patil S, Rohrer JS, Chakrabarti R, Dadke D, Lahori M, Zou C, Cairo C, Reiz B, Whittal RM, Lebrilla CB, Wu L, Guttman A, Szigeti M, Kremkow BG, Lee KH, Sihlbom C, Adamczyk B, Jin C, Karlsson NG, Örnros J, Larson G, Nilsson J, Meyer B, Wiegandt A, Komatsu E, Perreault H, Bodnar ED, Said N, Francois YN, Leize-Wagner E, Maier S, Zeck A, Heck AJR, Yang Y, Haselberg R, Yu YQ, Alley W, Leone JW, Yuan H, Stein SE. NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods. Mol Cell Proteomics. 2020 Jan; 19(1):11-30. PMID: 31591262.
      Citations:    
    19. Mantle JL, Rammohan J, Romantseva EF, Welch JT, Kauffman LR, McCarthy J, Schiel J, Baker JC, Strychalski EA, Rogers KC, Lee KH. Cyberbiosecurity for Biopharmaceutical Products. Front Bioeng Biotechnol. 2019; 7:116. PMID: 31214582.
      Citations:    
    20. Mantle JL, Lee KH. IgG transport increases in an in vitro blood-brain barrier model with Amyloid-ß and with neuroinflammatory cytokines. Biotechnol Bioeng. 2019 Mar 18. PMID: 30883675.
      Citations:    
    21. Dahodwala H, Lee KH. The fickle CHO: a review of the causes, implications, and potential alleviation of the CHO cell line instability problem. Curr Opin Biotechnol. 2019 Feb 28; 60:128-137. PMID: 30826670.
      Citations:    
    22. Hamaker NK, Lee KH. Site-specific Integration Ushers in a New Era of Precise CHO Cell Line Engineering. Curr Opin Chem Eng. 2018 Dec; 22:152-160. PMID: 31086757.
      Citations:    
    23. Ruano-Salguero JS, Lee KH. Efflux Pump Substrates Shuttled to Cytosolic or Vesicular Compartments Exhibit Different Permeability in a Quantitative Human Blood-Brain Barrier Model. Mol Pharm. 2018 Oct 01. PMID: 30212633.
      Citations:    
    24. MacDonald ML, Hamaker N, Lee KH. Bioinformatic analysis of Chinese hamster ovary host cell protein lipases. AIChE J. 2018 Dec; 64(12):4247-4254. PMID: 30911190.
      Citations:    
    25. Mantle JL, Lee KH. A differentiating neural stem cell-derived astrocytic population mitigates the inflammatory effects of TNF-a and IL-6 in an iPSC-based blood-brain barrier model. Neurobiol Dis. 2018 Nov; 119:113-120. PMID: 30075293.
      Citations:    
    26. Greene DG, Traylor SJ, Guo J, Choe LH, Modla S, Xu X, Singh N, Lock LL, Ghose S, Li ZJ, Lee KH, Wagner NJ, Lenhoff AM. Mechanisms of precipitate formation during the purification of an Fc-fusion protein. Biotechnol Bioeng. 2018 Jun 13. PMID: 29896879.
      Citations:    
    27. Rupp O, MacDonald ML, Li S, Dhiman H, Polson S, Griep S, Heffner K, Hernandez I, Brinkrolf K, Jadhav V, Samoudi M, Hao H, Kingham B, Goesmann A, Betenbaugh MJ, Lewis NE, Borth N, Lee KH. A reference genome of the Chinese hamster based on a hybrid assembly strategy. Biotechnol Bioeng. 2018 Apr 28. PMID: 29704459.
      Citations:    
    28. Kremkow BG, Lee KH. Glyco-Mapper: A Chinese hamster ovary (CHO) genome-specific glycosylation prediction tool. Metab Eng. 2018 Mar 06; 47:134-142. PMID: 29522825.
      Citations:    
    29. Sawicki LA, Choe LH, Wiley KL, Lee KH, Kloxin AM. Isolation and Identification of Proteins Secreted by Cells Cultured within Synthetic Hydrogel-Based Matrices. ACS Biomater Sci Eng. 2018 Mar 12; 4(3):836-845. PMID: 29552635.
      Citations:    
    30. Valente KN, Levy NE, Lee KH, Lenhoff AM. Applications of proteomic methods for CHO host cell protein characterization in biopharmaceutical manufacturing. Curr Opin Biotechnol. 2018 Feb 02; 53:144-150. PMID: 29414072.
      Citations:    
    31. Baik JY, Lee KH. Growth Rate Changes in CHO Host Cells Are Associated with Karyotypic Heterogeneity. Biotechnol J. 2018 Mar; 13(3):e1700230. PMID: 28865132.
      Citations:    
    32. Rehmann MS, Skeens KM, Kharkar PM, Ford EM, Maverakis E, Lee KH, Kloxin AM. Tuning and Predicting Mesh Size and Protein Release from Step Growth Hydrogels. Biomacromolecules. 2017 Oct 09; 18(10):3131-3142. PMID: 28850788.
      Citations:    
    33. Chiu J, Valente KN, Levy NE, Min L, Lenhoff AM, Lee KH. Knockout of a difficult-to-remove CHO host cell protein, lipoprotein lipase, for improved polysorbate stability in monoclonal antibody formulations. Biotechnol Bioeng. 2017 May; 114(5):1006-1015. PMID: 27943242.
      Citations:    
    34. Baik JY, Lee KH. A framework to quantify karyotype variation associated with CHO production instability. Biotechnol Bioeng. 2016 Dec 06. PMID: 27922175.
      Citations:    
    35. Harcum SW, Lee KH. CHO Cells Can Make More Protein. Cell Syst. 2016 Nov 23; 3(5):412-413. PMID: 27883886.
      Citations:    
    36. Mantle JL, Min L, Lee KH. Minimum Transendothelial Electrical Resistance Thresholds for the Study of Small and Large Molecule Drug Transport in a Human in Vitro Blood-Brain Barrier Model. Mol Pharm. 2016 Dec 05; 13(12):4191-4198. PMID: 27934481.
      Citations:    
    37. Levy AT, Lee KH, Hanson TE. Chlorobaculum tepidum Modulates Amino Acid Composition in Response to Energy Availability, as Revealed by a Systematic Exploration of the Energy Landscape of Phototrophic Sulfur Oxidation. Appl Environ Microbiol. 2016 Nov 1; 82(21):6431-6439. PMID: 27565613.
      Citations:    
    38. Baik JY, Lee KH. Toward improved host cell protein impurity assessment. Biotechnol J. 2016 Aug; 11(8):998-9. PMID: 27331371.
      Citations:    
    39. Heintz KA, Bregenzer ME, Mantle JL, Lee KH, West JL, Slater JH. Fabrication of 3D Biomimetic Microfluidic Networks in Hydrogels. Adv Healthc Mater. 2016 Sep; 5(17):2153-60. PMID: 27239785.
      Citations:    
    40. Levy NE, Valente KN, Lee KH, Lenhoff AM. Host cell protein impurities in chromatographic polishing steps for monoclonal antibody purification. Biotechnol Bioeng. 2016 Jun; 113(6):1260-72. PMID: 26550778.
      Citations:    
    41. Choi YS, Lee KH. Multiple reaction monitoring assay based on conventional liquid chromatography and electrospray ionization for simultaneous monitoring of multiple cerebrospinal fluid biomarker candidates for Alzheimer's disease. Arch Pharm Res. 2016 Mar; 39(3):390-7. PMID: 26404792.
      Citations:    
    42. Venkataramanan KP, Min L, Hou S, Jones SW, Ralston MT, Lee KH, Papoutsakis ET. Complex and extensive post-transcriptional regulation revealed by integrative proteomic and transcriptomic analysis of metabolite stress response in Clostridium acetobutylicum. Biotechnol Biofuels. 2015; 8:81. PMID: 26269711.
      Citations:    
    43. Min L, Choe LH, Lee KH. Improved protease digestion conditions for membrane protein detection. Electrophoresis. 2015 Aug; 36(15):1690-8. PMID: 25884272.
      Citations:    
    44. Kremkow BG, Baik JY, MacDonald ML, Lee KH. CHOgenome.org 2.0: Genome resources and website updates. Biotechnol J. 2015 Jul; 10(7):931-8. PMID: 25923813.
      Citations:    
    45. Valente KN, Lenhoff AM, Lee KH. Expression of difficult-to-remove host cell protein impurities during extended Chinese hamster ovary cell culture and their impact on continuous bioprocessing. Biotechnol Bioeng. 2015 Jun; 112(6):1232-42. PMID: 25502542.
      Citations:    
    46. Kremkow BG, Lee KH. Sequencing technologies for animal cell culture research. Biotechnol Lett. 2015 Jan; 37(1):55-65. PMID: 25214225.
      Citations:    
    47. Dordick JS, Lee KH. Editorial overview: Nanobiotechnology. Curr Opin Biotechnol. 2014 Aug; 28:iv-v. PMID: 24996481.
      Citations:    
    48. Shayan G, Adamiak B, Choe LH, Relkin N, Lee KH. Longitudinal effects of intravenous immunoglobulin on Alzheimer's cerebrospinal fluid proteome. Electrophoresis. 2014 Jul; 35(12-13):1821-7. PMID: 24756957.
      Citations:    
    49. Baik JY, Lee KH. Toward product attribute control: developments from genome sequencing. Curr Opin Biotechnol. 2014 Dec; 30:40-4. PMID: 24874795.
      Citations:    
    50. Wuest DM, Lee KH. Amyloid-ß concentration and structure influences the transport and immunomodulatory effects of IVIG. J Neurochem. 2014 Jul; 130(1):136-44. PMID: 24517534.
      Citations:    
    51. Baik JY, Lee KH. miRNA Expression in CHO: Nature knows best. Biotechnol J. 2014 Apr; 9(4):459-60. PMID: 24519876.
      Citations:    
    52. Yuk IH, Zhang JD, Ebeling M, Berrera M, Gomez N, Werz S, Meiringer C, Shao Z, Swanberg JC, Lee KH, Luo J, Szperalski B. Effects of copper on CHO cells: Insights from gene expression analyses. Biotechnol Prog. 2014 Mar; 30(2):429-42. PMID: 24403277.
      Citations:    
    53. Levy NE, Valente KN, Choe LH, Lee KH, Lenhoff AM. Identification and characterization of host cell protein product-associated impurities in monoclonal antibody bioprocessing. Biotechnol Bioeng. 2014 May; 111(5):904-12. PMID: 24254318.
      Citations:    
    54. Valente KN, Schaefer AK, Kempton HR, Lenhoff AM, Lee KH. Recovery of Chinese hamster ovary host cell proteins for proteomic analysis. Biotechnol J. 2014 Jan; 9(1):87-99. PMID: 24039059.
      Citations:    
    55. Choi YS, Hou S, Choe LH, Lee KH. Targeted human cerebrospinal fluid proteomics for the validation of multiple Alzheimer's disease biomarker candidates. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jul 1; 930:129-35. PMID: 23735279.
      Citations:    
    56. Hou S, Jones SW, Choe LH, Papoutsakis ET, Lee KH. Workflow for quantitative proteomic analysis of Clostridium acetobutylicum ATCC 824 using iTRAQ tags. Methods. 2013 Jun 15; 61(3):269-76. PMID: 23523702.
      Citations:    
    57. Wuest DM, Wing AM, Lee KH. Membrane configuration optimization for a murine in vitro blood-brain barrier model. J Neurosci Methods. 2013 Jan 30; 212(2):211-21. PMID: 23131353.
      Citations:    
    58. Villamil MA, Liang Q, Chen J, Choi YS, Hou S, Lee KH, Zhuang Z. Serine Phosphorylation Is Critical for the Activation of Ubiquitin-Specific Protease 1 and Its Interaction with WD40-Repeat Protein UAF1. Biochemistry. 2012 Nov 13; 51(45):9112-23. PMID: 23116119.
      Citations:    
    59. Valente KN, Choe LH, Lenhoff AM, Lee KH. Optimization of protein sample preparation for two-dimensional electrophoresis. Electrophoresis. 2012 Jul; 33(13):1947-57. PMID: 22806459.
      Citations:    
    60. Shayan G, Adamiak B, Relkin NR, Lee KH. Longitudinal analysis of novel Alzheimer's disease proteomic cerebrospinal fluid biomarkers during intravenous immunoglobulin therapy. Electrophoresis. 2012 Jul; 33(13):1975-9. PMID: 22806462.
      Citations:    
    61. Gupta P, Swanberg JC, Lee KH. A single nucleotide polymorphism in ycdC alters tRNA synthetase expression and results in hypersecretion in Escherichia coli. Biotechnol Prog. 2012 May; 28(3):646-53. PMID: 22505047.
      Citations:    
    62. Shayan G, Felix N, Cho Y, Chatzichristidi M, Shuler ML, Ober CK, Lee KH. Synthesis and characterization of high-throughput nanofabricated poly(4-hydroxy styrene) membranes for in vitro models of barrier tissue. Tissue Eng Part C Methods. 2012 Sep; 18(9):667-76. PMID: 22435738.
      Citations:    
    63. Hammond S, Swanberg JC, Polson SW, Lee KH. Profiling conserved microRNA expression in recombinant CHO cell lines using Illumina sequencing. Biotechnol Bioeng. 2012 Jun; 109(6):1371-5. PMID: 22189905.
      Citations:    
    64. Wuest DM, Lee KH. Optimization of endothelial cell growth in a murine in vitro blood-brain barrier model. Biotechnol J. 2012 Mar; 7(3):409-17. PMID: 22095877.
      Citations:    
    65. Hammond S, Kaplarevic M, Borth N, Betenbaugh MJ, Lee KH. Chinese hamster genome database: an online resource for the CHO community at www.CHOgenome.org. Biotechnol Bioeng. 2012 Jun; 109(6):1353-6. PMID: 22105744.
      Citations:    
    66. Wuest DM, Harcum SW, Lee KH. Genomics in mammalian cell culture bioprocessing. Biotechnol Adv. 2012 May-Jun; 30(3):629-38. PMID: 22079893.
      Citations:    
    67. Munro SA, Choe L, Zinder SH, Lee KH, Walker LP. Proteomic and physiological experiments to test Thermotoga neapolitana constraint-based model hypotheses of carbon source utilization. Biotechnol Prog. 2012 Mar-Apr; 28(2):312-8. PMID: 22034176.
      Citations:    
    68. Hammond S, Lee KH. RNA interference of cofilin in Chinese hamster ovary cells improves recombinant protein productivity. Biotechnol Bioeng. 2012 Feb; 109(2):528-35. PMID: 21915848.
      Citations:    
    69. Xu X, Nagarajan H, Lewis NE, Pan S, Cai Z, Liu X, Chen W, Xie M, Wang W, Hammond S, Andersen MR, Neff N, Passarelli B, Koh W, Fan HC, Wang J, Gui Y, Lee KH, Betenbaugh MJ, Quake SR, Famili I, Palsson BO, Wang J. The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line. Nat Biotechnol. 2011 Aug; 29(8):735-41. PMID: 21804562.
      Citations:    
    70. Shayan G, Shuler ML, Lee KH. The effect of astrocytes on the induction of barrier properties in aortic endothelial cells. Biotechnol Prog. 2011 Jul; 27(4):1137-45. PMID: 21626719.
      Citations:    
    71. Wu CY, Curtis A, Choi YS, Maeda M, Xu MJ, Berg A, Joneja U, Mason RW, Lee KH, Wang W. Identification of the phosphorylation sites in the survival motor neuron protein by protein kinase A. Biochim Biophys Acta. 2011 Sep; 1814(9):1134-9. PMID: 21609790.
      Citations:    
    72. Wu CY, Whye D, Glazewski L, Choe L, Kerr D, Lee KH, Mason RW, Wang W. Proteomic assessment of a cell model of spinal muscular atrophy. BMC Neurosci. 2011; 12:25. PMID: 21385431.
      Citations:    
    73. Hammond S, Swanberg JC, Kaplarevic M, Lee KH. Genomic sequencing and analysis of a Chinese hamster ovary cell line using Illumina sequencing technology. BMC Genomics. 2011; 12:67. PMID: 21269493.
      Citations:    
    74. Choi YS, Choe LH, Lee KH. Recent cerebrospinal fluid biomarker studies of Alzheimer's disease. Expert Rev Proteomics. 2010 Dec; 7(6):919-29. PMID: 21142892.
      Citations:    
    75. Shayan G, Choi YS, Shusta EV, Shuler ML, Lee KH. Murine in vitro model of the blood-brain barrier for evaluating drug transport. Eur J Pharm Sci. 2011 Jan 18; 42(1-2):148-55. PMID: 21078386.
      Citations:    
    76. Liao PY, Choi YS, Dinman JD, Lee KH. The many paths to frameshifting: kinetic modelling and analysis of the effects of different elongation steps on programmed -1 ribosomal frameshifting. Nucleic Acids Res. 2011 Jan; 39(1):300-12. PMID: 20823091.
      Citations:    
    77. Liao PY, Choi YS, Lee KH. FSscan: a mechanism-based program to identify +1 ribosomal frameshift hotspots. Nucleic Acids Res. 2009 Nov; 37(21):7302-11. PMID: 19783813.
      Citations:    
    78. Rudrappa T, Choi YS, Levia DF, Legates DR, Lee KH, Bais HP. Phragmites australis root secreted phytotoxin undergoes photo-degradation to execute severe phytotoxicity. Plant Signal Behav. 2009 Jun; 4(6):506-13. PMID: 19816146.
      Citations:    
    79. Gupta P, Lee KH. Silent mutations result in HlyA hypersecretion by reducing intracellular HlyA protein aggregates. Biotechnol Bioeng. 2008 Dec 1; 101(5):967-74. PMID: 18553505.
      Citations:    
    80. Griffiths LG, Choe L, Lee KH, Reardon KF, Orton EC. Protein extraction and 2-DE of water- and lipid-soluble proteins from bovine pericardium, a low-cellularity tissue. Electrophoresis. 2008 Nov; 29(22):4508-15. PMID: 18985661.
      Citations:    
    81. D'Ascenzo M, Choe L, Lee KH. iTRAQPak: an R based analysis and visualization package for 8-plex isobaric protein expression data. Brief Funct Genomic Proteomic. 2008 Mar; 7(2):127-35. PMID: 18272547.
      Citations:    
    82. Choe L, D'Ascenzo M, Relkin NR, Pappin D, Ross P, Williamson B, Guertin S, Pribil P, Lee KH. 8-plex quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer's disease. Proteomics. 2007 Oct; 7(20):3651-60. PMID: 17880003.
      Citations:    
    83. Kuczenski RS, Hong KC, García-Ojalvo J, Lee KH. PERIOD-TIMELESS interval timer may require an additional feedback loop. PLoS Comput Biol. 2007 Aug; 3(8):e154. PMID: 17676950.
      Citations:    
    84. Gupta P, Lee KH. Genomics and proteomics in process development: opportunities and challenges. Trends Biotechnol. 2007 Jul; 25(7):324-30. PMID: 17475353.
      Citations:    
    85. Finehout EJ, Franck Z, Choe LH, Relkin N, Lee KH. Cerebrospinal fluid proteomic biomarkers for Alzheimer's disease. Ann Neurol. 2007 Feb; 61(2):120-9. PMID: 17167789.
      Citations:    
    86. Lee DH, Kim SG, Park YC, Nam SW, Lee KH, Seo JH. Proteome analysis of recombinant Escherichia coli producing human glucagon-like peptide-1. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Apr 15; 849(1-2):323-30. PMID: 17049938.
      Citations:    
    87. Finehout EJ, Franck Z, Relkin N, Lee KH. Proteomic analysis of cerebrospinal fluid changes related to postmortem interval. Clin Chem. 2006 Oct; 52(10):1906-13. PMID: 16887899.
      Citations:    
    88. Choe LH, Werner BG, Lee KH. Two-dimensional protein electrophoresis: from molecular pathway discovery to biomarker discovery in neurological disorders. NeuroRx. 2006 Jul; 3(3):327-35. PMID: 16815216.
      Citations:    
    89. Aggarwal K, Choe LH, Lee KH. Shotgun proteomics using the iTRAQ isobaric tags. Brief Funct Genomic Proteomic. 2006 Jun; 5(2):112-20. PMID: 16772272.
      Citations:    
    90. Kuczenski RS, Aggarwal K, Lee KH. Improved understanding of gene expression regulation using systems biology. Expert Rev Proteomics. 2005 Dec; 2(6):915-24. PMID: 16307520.
      Citations:    
    91. D'Ascenzo M, Relkin NR, Lee KH. Alzheimer's disease cerebrospinal fluid biomarker discovery: a proteomics approach. Curr Opin Mol Ther. 2005 Dec; 7(6):557-64. PMID: 16372405.
      Citations:    
    92. Yang Y, Li C, Lee KH, Craighead HG. Coupling on-chip solid-phase extraction to electrospray mass spectrometry through an integrated electrospray tip. Electrophoresis. 2005 Oct; 26(19):3622-30. PMID: 16136527.
      Citations:    
    93. Aggarwal K, Choe LH, Lee KH. Quantitative analysis of protein expression using amine-specific isobaric tags in Escherichia coli cells expressing rhsA elements. Proteomics. 2005 Jun; 5(9):2297-308. PMID: 15887184.
      Citations:    
    94. Choe LH, Aggarwal K, Franck Z, Lee KH. A comparison of the consistency of proteome quantitation using two-dimensional electrophoresis and shotgun isobaric tagging in Escherichia coli cells. Electrophoresis. 2005 Jun; 26(12):2437-49. PMID: 15924362.
      Citations:    
    95. Hayduk EJ, Lee KH. Cytochalasin D can improve heterologous protein productivity in adherent Chinese hamster ovary cells. Biotechnol Bioeng. 2005 May 5; 90(3):354-64. PMID: 15772946.
      Citations:    
    96. Li C, Yang Y, Craighead HG, Lee KH. Isoelectric focusing in cyclic olefin copolymer microfluidic channels coated by polyacrylamide using a UV photografting method. Electrophoresis. 2005 May; 26(9):1800-6. PMID: 15800962.
      Citations:    
    97. Lee PS, Lee KH. Engineering HlyA hypersecretion in Escherichia coli based on proteomic and microarray analyses. Biotechnol Bioeng. 2005 Jan 20; 89(2):195-205. PMID: 15580578.
      Citations:    
    98. Finehout EJ, Franck Z, Lee KH. Complement protein isoforms in CSF as possible biomarkers for neurodegenerative disease. Dis Markers. 2005; 21(2):93-101. PMID: 15920296.
      Citations:    
    99. Hayduk EJ, Choe LH, Lee KH. A two-dimensional electrophoresis map of Chinese hamster ovary cell proteins based on fluorescence staining. Electrophoresis. 2004 Aug; 25(15):2545-56. PMID: 15300775.
      Citations:    
    100. Finehout EJ, Franck Z, Lee KH. Towards two-dimensional electrophoresis mapping of the cerebrospinal fluid proteome from a single individual. Electrophoresis. 2004 Aug; 25(15):2564-75. PMID: 15300777.
      Citations:    
    101. Lee WC, Lee KH. Applications of affinity chromatography in proteomics. Anal Biochem. 2004 Jan 1; 324(1):1-10. PMID: 14654038.
      Citations:    
    102. Lee PS, Lee KH. Escherichia coli--a model system that benefits from and contributes to the evolution of proteomics. Biotechnol Bioeng. 2003 Dec 30; 84(7):801-14. PMID: 14708121.
      Citations:    
    103. Mehra A, Lee KH, Hatzimanikatis V. Insights into the relation between mRNA and protein expression patterns: I. Theoretical considerations. Biotechnol Bioeng. 2003 Dec 30; 84(7):822-33. PMID: 14708123.
      Citations:    
    104. Lee PS, Shaw LB, Choe LH, Mehra A, Hatzimanikatis V, Lee KH. Insights into the relation between mrna and protein expression patterns: II. Experimental observations in Escherichia coli. Biotechnol Bioeng. 2003 Dec 30; 84(7):834-41. PMID: 14708124.
      Citations:    
    105. Aggarwal K, Lee KH. Functional genomics and proteomics as a foundation for systems biology. Brief Funct Genomic Proteomic. 2003 Oct; 2(3):175-84. PMID: 15239921.
      Citations:    
    106. Choe LH, Lee KH. Quantitative and qualitative measure of intralaboratory two-dimensional protein gel reproducibility and the effects of sample preparation, sample load, and image analysis. Electrophoresis. 2003 Oct; 24(19-20):3500-7. PMID: 14595697.
      Citations:    
    107. Finehout EJ, Lee KH. Comparison of automated in-gel digest methods for femtomole level samples. Electrophoresis. 2003 Oct; 24(19-20):3508-16. PMID: 14595698.
      Citations:    
    108. Reardon KF, Lee KH, Wittrup KD, Hatzimanikatis V. Jay Bailey as mentor--the students' perspective. Biotechnol Bioeng. 2002 Sep 5; 79(5):484-9. PMID: 12209819.
      Citations:    
    109. Choe LH, Green A, Knight RS, Thompson EJ, Lee KH. Apolipoprotein E and other cerebrospinal fluid proteins differentiate ante mortem variant Creutzfeldt-Jakob disease from ante mortem sporadic Creutzfeldt-Jakob disease. Electrophoresis. 2002 Jul; 23(14):2242-6. PMID: 12210228.
      Citations:    
    110. Choe LH, Dutt MJ, Relkin N, Lee KH. Studies of potential cerebrospinal fluid molecular markers for Alzheimer's disease. Electrophoresis. 2002 Jul; 23(14):2247-51. PMID: 12210229.
      Citations:    
    Lee's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (261)
    Explore
    _
    Co-Authors (4)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _