Thomas Jefferson University

Daniel C Flynn

TitleAssoc Prof CHP
InstitutionThomas Jefferson University
DepartmentNursing - Undergraduate
Address25 North College Ave.
Newark DE 19716
Phone302-831-7578
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Flynn DC, Bhagwat AR, Brenner MH, N??ez MF, Mork BE, Cai D, Swanson JA, Ogilvie JP. Pulse-shaping based two-photon FRET stoichiometry. Opt Express. 2015 Feb 09; 23(3):3353-72. PMID: 25836193.
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    2. Arnold KM, Opdenaker LM, Flynn D, Sims-Mourtada J. Wound healing and cancer stem cells: inflammation as a driver of treatment resistance in breast cancer. Cancer Growth Metastasis. 2015; 8:1-13. PMID: 25674014.
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    3. Opdenaker LM, Arnold KM, Pohlig RT, Padmanabhan JS, Flynn DC, Sims-Mourtada J. Immunohistochemical analysis of aldehyde dehydrogenase isoforms and their association with estrogen-receptor status and disease progression in breast cancer. Breast Cancer (Dove Med Press). 2014; 6:205-9. PMID: 25540596.
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    4. Khan SH, Ahmad F, Ahmad N, Flynn DC, Kumar R. Protein-protein interactions: principles, techniques, and their potential role in new drug development. J Biomol Struct Dyn. 2011 Jun; 28(6):929-38. PMID: 21469753.
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    5. Snyder BN, Cho Y, Qian Y, Coad JE, Flynn DC, Cunnick JM. AFAP1L1 is a novel adaptor protein of the AFAP family that interacts with cortactin and localizes to invadosomes. Eur J Cell Biol. 2011 May; 90(5):376-89. PMID: 21333378.
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    6. Clump DA, Yu JJ, Cho Y, Gao R, Jett J, Zot H, Cunnick JM, Snyder B, Clump AC, Dodrill M, Gannett P, Coad JE, Shurina R, Figg WD, Reed E, Flynn DC. A Polymorphic Variant of AFAP-110 Enhances cSrc Activity. Transl Oncol. 2010 Aug 01; 3(4):276-85. PMID: 20689769.
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    7. Flynn DC, Ramakrishna G, Yang HB, Northrop BH, Stang PJ, Goodson T. Ultrafast optical excitations in supramolecular metallacycles with charge transfer properties. J Am Chem Soc. 2010 Feb 03; 132(4):1348-58. PMID: 20055383.
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    8. Apopa PL, Qian Y, Shao R, Guo NL, Schwegler-Berry D, Pacurari M, Porter D, Shi X, Vallyathan V, Castranova V, Flynn DC. Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling. Part Fibre Toxicol. 2009 Jan 09; 6:1. PMID: 19134195.
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    9. Guo NL, Wan YW, Tosun K, Lin H, Msiska Z, Flynn DC, Remick SC, Vallyathan V, Dowlati A, Shi X, Castranova V, Beer DG, Qian Y. Confirmation of gene expression-based prediction of survival in non-small cell lung cancer. Clin Cancer Res. 2008 Dec 15; 14(24):8213-20. PMID: 19088038.
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    10. Xu X, Harder J, Flynn DC, Lanier LM. AFAP120 regulates actin organization during neuronal differentiation. Differentiation. 2009 Jan; 77(1):38-47. PMID: 19281763.
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    11. Dorfleutner A, Cho Y, Vincent D, Cunnick J, Lin H, Weed SA, Stehlik C, Flynn DC. Phosphorylation of AFAP-110 affects podosome lifespan in A7r5 cells. J Cell Sci. 2008 Jul 15; 121(Pt 14):2394-405. PMID: 18577577.
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    12. Flynn DC, Cho Y, Vincent D, Cunnick JM. Podosomes and Invadopodia: Related structures with Common Protein Components that May Promote Breast Cancer Cellular Invasion. Breast Cancer (Auckl). 2008; 2:17-29. PMID: 21655365.
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    13. Guo L, Abraham J, Flynn DC, Castranova V, Shi X, Qian Y. Individualized Survival and Treatment Response Predictions in Breast Cancer Patients: Involvements of Phospho-EGFR and Phospho-Her2/neu Proteins. Open Clin Cancer J. 2008 May 27; 2:18-31. PMID: 25558292.
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    14. Dorfleutner A, Stehlik C, Zhang J, Gallick GE, Flynn DC. AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells. J Cell Physiol. 2007 Dec; 213(3):740-9. PMID: 17520695.
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    15. Qian Y, Luo J, Leonard SS, Harris GK, Millecchia L, Flynn DC, Shi X. Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis. Nihon Arukoru Yakubutsu Igakkai Zasshi. 2007 Dec; 42(6):605-9. PMID: 18240647.
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    16. Zhang J, Park SI, Artime MC, Summy JM, Shah AN, Bomser JA, Dorfleutner A, Flynn DC, Gallick GE. AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts. J Clin Invest. 2007 Oct; 117(10):2962-73. PMID: 17885682.
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    17. Dorfleutner A, Talbott SJ, Bryan NB, Funya KN, Rellick SL, Reed JC, Shi X, Rojanasakul Y, Flynn DC, Stehlik C. A Shope Fibroma virus PYRIN-only protein modulates the host immune response. Virus Genes. 2007 Dec; 35(3):685-94. PMID: 17676277.
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    18. Ma Y, Qian Y, Wei L, Abraham J, Shi X, Castranova V, Harner EJ, Flynn DC, Guo L. Population-based molecular prognosis of breast cancer by transcriptional profiling. Clin Cancer Res. 2007 Apr 01; 13(7):2014-22. PMID: 17404081.
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    19. Walker VG, Ammer A, Cao Z, Clump AC, Jiang BH, Kelley LC, Weed SA, Zot H, Flynn DC. PI3K activation is required for PMA-directed activation of cSrc by AFAP-110. Am J Physiol Cell Physiol. 2007 Jul; 293(1):C119-32. PMID: 17360811.
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    20. Sun XH, Flynn DC, Castranova V, Millecchia LL, Beardsley AR, Liu J. Identification of a novel domain at the N terminus of caveolin-1 that controls rear polarization of the protein and caveolae formation. J Biol Chem. 2007 Mar 09; 282(10):7232-41. PMID: 17213184.
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    21. Yu JJ, Flynn DC. EGFR artifactual mutations associated with two DNA sequencers. Biotechniques. 2007 Jan; 42(1):41. PMID: 17269483.
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    22. Dorfleutner A, Bryan NB, Talbott SJ, Funya KN, Rellick SL, Reed JC, Shi X, Rojanasakul Y, Flynn DC, Stehlik C. Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation. Infect Immun. 2007 Mar; 75(3):1484-92. PMID: 17178784.
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    23. Jiang BH, Liu LZ, Schafer R, Flynn DC, Barnett JB. A novel role for 3, 4-dichloropropionanilide (DCPA) in the inhibition of prostate cancer cell migration, proliferation, and hypoxia-inducible factor 1alpha expression. BMC Cancer. 2006; 6:204. PMID: 16884534.
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    24. Helfer B, Boswell BC, Finlay D, Cipres A, Vuori K, Bong Kang T, Wallach D, Dorfleutner A, Lahti JM, Flynn DC, Frisch SM. Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions. Cancer Res. 2006 Apr 15; 66(8):4273-8. PMID: 16618751.
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    25. Clump DA, Qazi IH, Sudol M, Flynn DC. c-Yes response to growth factor activation. Growth Factors. 2005 Dec; 23(4):263-72. PMID: 16338789.
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    26. Stettner MR, Wang W, Nabors LB, Bharara S, Flynn DC, Grammer JR, Gillespie GY, Gladson CL. Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells. Cancer Res. 2005 Jul 01; 65(13):5535-43. PMID: 15994925.
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    27. Qian Y, Zhong X, Flynn DC, Zheng JZ, Qiao M, Wu C, Dedhar S, Shi X, Jiang BH. ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling. Oncogene. 2005 Apr 28; 24(19):3154-65. PMID: 15735674.
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    28. Qian Y, Liu KJ, Chen Y, Flynn DC, Castranova V, Shi X. Cdc42 regulates arsenic-induced NADPH oxidase activation and cell migration through actin filament reorganization. J Biol Chem. 2005 Feb 04; 280(5):3875-84. PMID: 15492012.
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    29. Gatesman A, Walker VG, Baisden JM, Weed SA, Flynn DC. Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110. Mol Cell Biol. 2004 Sep; 24(17):7578-97. PMID: 15314167.
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    30. Gao N, Flynn DC, Zhang Z, Zhong XS, Walker V, Liu KJ, Shi X, Jiang BH. G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells. Am J Physiol Cell Physiol. 2004 Aug; 287(2):C281-91. PMID: 15028555.
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    31. Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC. Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity. J Cell Biochem. 2004 Feb 15; 91(3):602-20. PMID: 14755689.
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    32. Belcastro M, Miller MR, Flynn DC, Soisson AP. C/EBPbeta activity and HPV-16 E6/E7 mRNA expression are not altered by imiquimod (ALDARA) in human cervical cancer cells in vitro. Gynecol Oncol. 2004 Feb; 92(2):660-8. PMID: 14766263.
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    33. Qian Y, Corum L, Meng Q, Blenis J, Zheng JZ, Shi X, Flynn DC, Jiang BH. PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration. Am J Physiol Cell Physiol. 2004 Jan; 286(1):C153-63. PMID: 12967912.
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    34. Summy JM, Qian Y, Jiang BH, Guappone-Koay A, Gatesman A, Shi X, Flynn DC. The SH4-Unique-SH3-SH2 domains dictate specificity in signaling that differentiate c-Yes from c-Src. J Cell Sci. 2003 Jun 15; 116(Pt 12):2585-98. PMID: 12734402.
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    35. Qian Y, Luo J, Leonard SS, Harris GK, Millecchia L, Flynn DC, Shi X. Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis. J Biol Chem. 2003 May 02; 278(18):16189-97. PMID: 12598535.
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    36. Clump DA, Clem R, Qian Y, Guappone-Koay A, Berrebi AS, Flynn DC. Protein expression levels of the Src activating protein AFAP are developmentally regulated in brain. J Neurobiol. 2003 Feb 15; 54(3):473-85. PMID: 12532398.
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    37. Summy JM, Sudol M, Eck MJ, Monteiro AN, Gatesman A, Flynn DC. Specificity in signaling by c-Yes. Front Biosci. 2003 Jan 01; 8:s185-205. PMID: 12456296.
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    38. Gao N, Jiang BH, Leonard SS, Corum L, Zhang Z, Roberts JR, Antonini J, Zheng JZ, Flynn DC, Castranova V, Shi X. p38 Signaling-mediated hypoxia-inducible factor 1alpha and vascular endothelial growth factor induction by Cr(VI) in DU145 human prostate carcinoma cells. J Biol Chem. 2002 Nov 22; 277(47):45041-8. PMID: 12213806.
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    39. Qian Y, Baisden JM, Cherezova L, Summy JM, Guappone-Koay A, Shi X, Mast T, Pustula J, Zot HG, Mazloum N, Lee MY, Flynn DC. PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments. Mol Biol Cell. 2002 Jul; 13(7):2311-22. PMID: 12134071.
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    40. Cherezova L, Gatesman A, Flynn DC. The effects of phosphorylation on adaptor protein function. Front Biosci. 2002 Jan 01; 7:d164-203. PMID: 11779691.
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