Actins

"Actins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.

Descriptor ID	D000199
MeSH Number(s)	D05.750.078.730.250 D12.776.210.500.100 D12.776.220.525.255
Concept/Terms	Actins Actins Actin alpha-Isoactin alpha-Isoactin alpha Isoactin beta-Actin beta-Actin beta Actin N-Actin N-Actin N Actin G-Actin G-Actin G Actin gamma-Actin gamma-Actin gamma Actin Isoactin Isoactin alpha-Actin alpha-Actin alpha Actin F-Actin F-Actin F Actin

Below are MeSH descriptors whose meaning is more general than "Actins".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Polymers [D05.750]
Biopolymers [D05.750.078]
Microfilament Proteins [D05.750.078.730]
Actins [D05.750.078.730.250]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Contractile Proteins [D12.776.210]
Muscle Proteins [D12.776.210.500]
Actins [D12.776.210.500.100]
Cytoskeletal Proteins [D12.776.220]
Microfilament Proteins [D12.776.220.525]
Actins [D12.776.220.525.255]

Below are MeSH descriptors whose meaning is more specific than "Actins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Actins" by people in this website by year, and whether "Actins" was a major or minor topic of these publications.

Bar chart showing 144 publications over 30 distinct years, with a maximum of 9 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	3	3
1997	3	1	4
1998	1	4	5
1999	0	6	6
2000	2	3	5
2001	2	4	6
2002	3	6	9
2003	2	6	8
2004	3	5	8
2005	2	2	4
2006	2	5	7
2007	1	3	4
2008	1	5	6
2009	1	3	4
2010	1	4	5
2011	2	1	3
2012	3	5	8
2013	2	4	6
2014	0	6	6
2015	2	3	5
2016	0	5	5
2017	1	3	4
2018	1	1	2
2019	0	2	2
2020	0	2	2
2021	0	6	6
2022	2	1	3
2023	2	3	5
2024	1	1	2
2025	1	0	1

Below are the most recent publications written about "Actins" by people in Profiles.

Moazzeni S, Kyker-Snowman K, Cohen RI, Wang H, Li R, Shreiber DI, Zahn JD, Shi Z, Lin H. N-Cadherin based adhesion and Rac1 activity regulate tension polarization in the actin cortex. Sci Rep. 2025 02 04; 15(1):4296.

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Tymanskyj SR, Escorce A, Karthikeyan S, Ma L. Optogenetic control of receptor-mediated growth cone dynamics in neurons. Mol Biol Cell. 2025 Feb 01; 36(2):br5.

View in: PubMed
Garg A, Jansen S, Greenberg L, Zhang R, Lavine KJ, Greenberg MJ. Dilated cardiomyopathy-associated skeletal muscle actin (ACTA1) mutation R256H disrupts actin structure and function and causes cardiomyocyte hypocontractility. Proc Natl Acad Sci U S A. 2024 11 12; 121(46):e2405020121.

View in: PubMed
Nayak AP, Javed E, Villalba DR, Wang Y, Morelli HP, Shah SD, Kim N, Ostrom RS, Panettieri RA, An SS, Tang DD, Penn RB. Prorelaxant E-type Prostanoid Receptors Functionally Partition to Different Procontractile Receptors in Airway Smooth Muscle. Am J Respir Cell Mol Biol. 2023 11; 69(5):584-591.

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Ogunmowo TH, Jing H, Raychaudhuri S, Kusick GF, Imoto Y, Li S, Itoh K, Ma Y, Jafri H, Dalva MB, Chapman ER, Ha T, Watanabe S, Liu J. Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis. Nat Commun. 2023 05 20; 14(1):2888.

View in: PubMed
Clippinger Schulte SR, Scott B, Barrick SK, Stump WT, Blackwell T, Greenberg MJ. Single-molecule mechanics and kinetics of cardiac myosin interacting with regulated thin filaments. Biophys J. 2023 06 20; 122(12):2544-2555.

View in: PubMed
Lee LA, Barrick SK, Buvoli AE, Walklate J, Stump WT, Geeves M, Greenberg MJ, Leinwand LA. Distinct effects of two hearing loss-associated mutations in?the sarcomeric myosin MYH7b. J Biol Chem. 2023 05; 299(5):104631.

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Haines A, Wesolowski J, Paumet F. Chlamydia trachomatis Subverts Alpha-Actinins To Stabilize Its Inclusion. Microbiol Spectr. 2023 02 14; 11(1):e0261422.

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Tompkins E, Mimic B, Cuevas-Mora K, Schorsch H, Shah SD, Deshpande DA, Benovic JL, Penn RB, Pera T. PD 102807 Induces M3 mAChR-Dependent GRK-/Arrestin-Biased Signaling in Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol. 2022 11; 67(5):550-561.

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Menko AS, Walker JL. The Pro-Fibrotic Response to Lens Injury Is Signaled in a PI3K Isoform-Specific Manner. Biomolecules. 2022 08 25; 12(9).

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