Ulhas P Naik

TitleProfessor
InstitutionUniversity of Delaware
DepartmentBiological Sciences
Address105 The Green
Newark DE 19716
Phone302-831-0434
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    Other Positions
    TitleDirector
    InstitutionUniversity of Delaware
    DepartmentCollege of Arts and Sciences

    TitleProfessor
    InstitutionUniversity of Delaware
    DepartmentChemical and Biomolecular Engineering


    Collapse Research 
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    R29HL057630     (NAIK, ULHAS P)Jul 1, 1997 - Jun 30, 2003
    NIH
    MODULATION OF INTEGRIN FUNCTION BY CYTOPLASMIC SIGNALING
    Role: Principal Investigator

    R01HL057630     (NAIK, ULHAS P)Jul 1, 1997 - Jun 30, 2010
    NIH
    Modulation of integrin function by cytoplasmic signals
    Role: Principal Investigator

    R01HL063960     (NAIK, ULHAS P)Dec 1, 1999 - Nov 30, 2011
    NIH
    Role of JAM Family in Angiogenesis
    Role: Principal Investigator

    R01HL113188     (NAIK, ULHAS P)Feb 1, 2013 - Mar 31, 2023
    NIH
    ASK1 a novel regulator of platelet function
    Role: Principal Investigator

    R01HL119374     (NAIK, ULHAS P)Aug 1, 2013 - Jun 30, 2023
    NIH
    Endogenous suppression of integrin signaling
    Role: Principal Investigator

    R01HL142959     (NAIK, ULHAS P)Jul 1, 2019 - Jun 30, 2023
    NIH
    Regulation of Platelet Reactivity by S1P Signaling
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Patel P, Michael JV, Naik UP, McKenzie SE. Platelet Fc?RIIA in immunity and thrombosis: Adaptive immunothrombosis. J Thromb Haemost. 2021 May; 19(5):1149-1160. PMID: 33587783.
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    2. Lauko A, Mu Z, Gutmann DH, Naik UP, Lathia JD. Junctional adhesion molecules in cancer: a paradigm for the diverse functions of cell-cell interactions in tumor progression. Cancer Res. 2020 Aug 14. PMID: 32816855.
      Citations:    
    3. Patel P, Shaik NF, Zhou Y, Golla K, McKenzie SE, Naik UP. ASK1 Regulates Immune-Mediated Thrombocytopenia, Thrombosis, and Systemic Shock. J Thromb Haemost. 2020 Aug 07. PMID: 32767736.
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    4. Patel P, Naik UP. Platelet MAPKs a 20+year history: what do we really know? J Thromb Haemost. 2020 Jun 23. PMID: 32574399.
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    5. Chen X, Gupta S, Cooper M, DeHelian D, Zhao X, Naik MU, Wurtzel JGT, Stalker TJ, Goldfinger LE, Benovic J, Brass LF, McKenzie SE, Naik UP, Ma P. GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets. Blood Adv. 2020 Jan 14; 4(1):76-86. PMID: 31899801.
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    6. Chen J, Zhang J, Shaik NF, Yi B, Wei X, Yang XF, Naik UP, Summer R, Yan G, Xu X, Sun J. The histone deacetylase inhibitor tubacin mitigates endothelial dysfunction by up-regulating the expression of endothelial nitric oxide synthase. J Biol Chem. 2019 Dec 20; 294(51):19565-19576. PMID: 31719145.
      Citations:    
    7. Patel P, Naik MU, Golla K, Shaik NF, Naik UP. ----Calcium-induced dissociation of CIB1 from ASK1 regulates agonist-induced activation of the p38 MAPK pathway in platelets. Biochem J. 2019 Sep 17. PMID: 31530712.
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    8. Yoon KW, Yang HS, Kim YM, Kim Y, Kang S, Sun W, Naik UP, Parise LV, Choi EJ. CIB1 protects against MPTP-induced neurotoxicity through inhibiting ASK1. Sci Rep. 2017 Sep 22; 7(1):12178. PMID: 28939911.
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    9. Naik MU, Naik TU, Summer R, Naik UP. Binding of CIB1 to the aIIb tail of aIIbß3 is required for FAK recruitment and activation in platelets. PLoS One. 2017; 12(5):e0176602. PMID: 28542214.
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    10. Naik MU, Patel P, Derstine R, Turaga R, Chen X, Golla K, Neeves KB, Ichijo H, Naik UP. Ask1 regulates murine platelet granule secretion, thromboxane A2 generation, and thrombus formation. Blood. 2017 Mar 02; 129(9):1197-1209. PMID: 28028021.
      Citations:    
    11. Naik KU, Naik UP. Manipulating integrin signaling for anti-thrombotic benefits. Cell Adh Migr. 2015 Jul 4; 9(4):277-9. PMID: 25482619.
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    12. Naik UP. Bacteria exploit platelets. Blood. 2014 May 15; 123(20):3067-8. PMID: 24832941.
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    13. Lathia JD, Li M, Sinyuk M, Alvarado AG, Flavahan WA, Stoltz K, Rosager AM, Hale J, Hitomi M, Gallagher J, Wu Q, Martin J, Vidal JG, Nakano I, Dahlrot RH, Hansen S, McLendon RE, Sloan AE, Bao S, Hjelmeland AB, Carson CT, Naik UP, Kristensen B, Rich JN. High-throughput flow cytometry screening reveals a role for junctional adhesion molecule a as a cancer stem cell maintenance factor. Cell Rep. 2014 Jan 16; 6(1):117-29. PMID: 24373972.
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    14. Naik MU, Caplan JL, Naik UP. Junctional adhesion molecule-A suppresses platelet integrin aIIbß3 signaling by recruiting Csk to the integrin-c-Src complex. Blood. 2014 Feb 27; 123(9):1393-402. PMID: 24300854.
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    15. Chatterjee S, Wang Y, Duncan MK, Naik UP. Junctional adhesion molecule-a regulates vascular endothelial growth factor receptor-2 signaling-dependent mouse corneal wound healing. PLoS One. 2013; 8(5):e63674. PMID: 23667656.
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    16. Manne BK, Getz TM, Hughes CE, Alshehri O, Dangelmaier C, Naik UP, Watson SP, Kunapuli SP. Fucoidan Is a Novel Platelet Agonist for the C-type Lectin-like Receptor 2 (CLEC-2). J Biol Chem. 2013 Mar 15; 288(11):7717-26. PMID: 23341451.
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    17. Lakshmi SP, Reddy AT, Naik MU, Naik UP, Reddy RC. Effects of JAM-A deficiency or blocking antibodies on neutrophil migration and lung injury in a murine model of ALI. Am J Physiol Lung Cell Mol Physiol. 2012 Nov 1; 303(9):L758-66. PMID: 22904169.
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    18. Aravindan RG, Fomin VP, Naik UP, Modelski MJ, Naik MU, Galileo DS, Duncan RL, Martin-Deleon PA. CASK interacts with PMCA4b and JAM-A on the mouse sperm flagellum to regulate Ca2+ homeostasis and motility. J Cell Physiol. 2012 Aug; 227(8):3138-50. PMID: 22020416.
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    19. Chatterjee S, Naik UP. Pericyte-endothelial cell interaction: a survival mechanism for the tumor vasculature. Cell Adh Migr. 2012 May-Jun; 6(3):157-9. PMID: 22568989.
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    20. Naik MU, Stalker TJ, Brass LF, Naik UP. JAM-A protects from thrombosis by suppressing integrin aIIbß3-dependent outside-in signaling in platelets. Blood. 2012 Apr 5; 119(14):3352-60. PMID: 22271446.
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    21. Kostyak JC, Naik MU, Naik UP. Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration. Blood. 2012 Jan 19; 119(3):838-46. PMID: 22128142.
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    22. Naik MU, Naik UP. Contra-regulation of calcium- and integrin-binding protein 1-induced cell migration on fibronectin by PAK1 and MAP kinase signaling. J Cell Biochem. 2011 Nov; 112(11):3289-99. PMID: 21748785.
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    23. Welf ES, Naik UP, Ogunnaike BA. Probabilistic modeling and analysis of the effects of extra-cellular matrix density on the sizes, shapes, and locations of integrin clusters in adherent cells. BMC Biophys. 2011; 4:15. PMID: 21827670.
      Citations:    
    24. Naik MU, Pham NT, Beebe K, Dai W, Naik UP. Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells. Int J Cancer. 2011 Feb 1; 128(3):587-96. PMID: 20473878.
      Citations:    
    25. Kostyak JC, Naik UP. Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells. PLoS One. 2011; 6(1):e14513. PMID: 21264284.
      Citations:    
    26. Johnson DA, Rose WC, Edwards JW, Naik UP, Beris AN. Application of 1D blood flow models of the human arterial network to differential pressure predictions. J Biomech. 2011 Mar 15; 44(5):869-76. PMID: 21236432.
      Citations:    
    27. Chari-Turaga R, Naik UP. Integrin aIIbß3: a novel effector of Ga13. Cell Adh Migr. 2011 Jan-Feb; 5(1):4-5. PMID: 20930548.
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    28. Naik MU, Naik UP. Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression. Int J Biochem Cell Biol. 2011 Jan; 43(1):120-9. PMID: 20951827.
      Citations:    
    29. Naik UP. PTEN: not just a tumor suppressor. Blood. 2010 Oct 7; 116(14):2404-5. PMID: 20930079.
      Citations:    
    30. Millili PG, Selekman JA, Blocker KM, Johnson DA, Naik UP, Sullivan MO. Structural and functional consequences of poly(ethylene glycol) inclusion on DNA condensation for gene delivery. Microsc Res Tech. 2010 Sep; 73(9):866-77. PMID: 20232467.
      Citations:    
    31. Millili PG, Yin DH, Fan H, Naik UP, Sullivan MO. Formulation of a Peptide nucleic Acid based nucleic Acid delivery construct. Bioconjug Chem. 2010 Mar 17; 21(3):445-55. PMID: 20131756.
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    32. Naik UP. Lyn and PKCdelta order SHIP1 embargo. Blood. 2009 Oct 1; 114(14):2856-7. PMID: 19797530.
      Citations:    
    33. Yoon KW, Cho JH, Lee JK, Kang YH, Chae JS, Kim YM, Kim J, Kim EK, Kim SE, Baik JH, Naik UP, Cho SG, Choi EJ. CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17389-94. PMID: 19805025.
      Citations:    
    34. Naik MU, Nigam A, Manrai P, Millili P, Czymmek K, Sullivan M, Naik UP. CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin alpha IIb beta 3. J Thromb Haemost. 2009 Nov; 7(11):1906-14. PMID: 19691476.
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    35. Weitzman M, Bayley EB, Naik UP. Robo4: a guidance receptor that regulates angiogenesis. Cell Adh Migr. 2008 Oct-Dec; 2(4):220-2. PMID: 19270536.
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    36. Naik UP, Naik MU. Putting the brakes on cancer cell migration: JAM-A restrains integrin activation. Cell Adh Migr. 2008 Oct-Dec; 2(4):249-51. PMID: 19262151.
      Citations:    
    37. Naik MU, Naik TU, Suckow AT, Duncan MK, Naik UP. Attenuation of junctional adhesion molecule-A is a contributing factor for breast cancer cell invasion. Cancer Res. 2008 Apr 1; 68(7):2194-203. PMID: 18381425.
      Citations:    
    38. Naik TU, Naik MU, Naik UP. Junctional adhesion molecules in angiogenesis. Front Biosci. 2008; 13:258-62. PMID: 17981544.
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    39. Braiterman LT, Heffernan S, Nyasae L, Johns D, See AP, Yutzy R, McNickle A, Herman M, Sharma A, Naik UP, Hubbard AL. JAM-A is both essential and inhibitory to development of hepatic polarity in WIF-B cells. Am J Physiol Gastrointest Liver Physiol. 2008 Feb; 294(2):G576-88. PMID: 18096610.
      Citations:    
    40. Shao M, Ghosh A, Cooke VG, Naik UP, Martin-DeLeon PA. JAM-A is present in mammalian spermatozoa where it is essential for normal motility. Dev Biol. 2008 Jan 1; 313(1):246-55. PMID: 18022613.
      Citations:    
    41. Bonner MA, Naik UP. Cytoplasmic binding partners of the platelet integrin alphaIIb beta3. Front Biosci. 2007; 12:2038-49. PMID: 17127442.
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    42. Kostyak JC, Naik UP. Megakaryopoiesis: transcriptional insights into megakaryocyte maturation. Front Biosci. 2007; 12:2050-62. PMID: 17127443.
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    43. Kang LI, Wang Y, Suckow AT, Czymmek KJ, Cooke VG, Naik UP, Duncan MK. Deletion of JAM-A causes morphological defects in the corneal epithelium. Int J Biochem Cell Biol. 2007; 39(3):576-85. PMID: 17118692.
      Citations:    
    44. Cooke VG, Naik MU, Naik UP. Fibroblast growth factor-2 failed to induce angiogenesis in junctional adhesion molecule-A-deficient mice. Arterioscler Thromb Vasc Biol. 2006 Sep; 26(9):2005-11. PMID: 16809549.
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    45. Naik MU, Naik UP. Junctional adhesion molecule-A-induced endothelial cell migration on vitronectin is integrin alpha v beta 3 specific. J Cell Sci. 2006 Feb 1; 119(Pt 3):490-9. PMID: 16418218.
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    46. Parris JJ, Cooke VG, Skarnes WC, Duncan MK, Naik UP. JAM-A expression during embryonic development. Dev Dyn. 2005 Aug; 233(4):1517-24. PMID: 15977176.
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    47. Blamey CJ, Ceccarelli C, Naik UP, Bahnson BJ. The crystal structure of calcium- and integrin-binding protein 1: insights into redox regulated functions. Protein Sci. 2005 May; 14(5):1214-21. PMID: 15840829.
      Citations:    
    48. Cui W, Ning J, Naik UP, Duncan MK. OptiRNAi, an RNAi design tool. Comput Methods Programs Biomed. 2004 Jul; 75(1):67-73. PMID: 15158049.
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    49. Naik MU, Vuppalanchi D, Naik UP. Essential role of junctional adhesion molecule-1 in basic fibroblast growth factor-induced endothelial cell migration. Arterioscler Thromb Vasc Biol. 2003 Dec; 23(12):2165-71. PMID: 12958043.
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    50. Naik MU, Naik UP. Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen. Blood. 2003 Nov 15; 102(10):3629-36. PMID: 12881299.
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    51. Naik MU, Mousa SA, Parkos CA, Naik UP. Signaling through JAM-1 and alphavbeta3 is required for the angiogenic action of bFGF: dissociation of the JAM-1 and alphavbeta3 complex. Blood. 2003 Sep 15; 102(6):2108-14. PMID: 12750158.
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    52. Naik UP, Naik MU. Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen. Blood. 2003 Aug 15; 102(4):1355-62. PMID: 12714504.
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    53. Wang Q, Xie S, Chen J, Fukasawa K, Naik U, Traganos F, Darzynkiewicz Z, Jhanwar-Uniyal M, Dai W. Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity. Mol Cell Biol. 2002 May; 22(10):3450-9. PMID: 11971976.
      Citations:    
    54. Naik UP, Naik MU, Eckfeld K, Martin-DeLeon P, Spychala J. Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibody. J Cell Sci. 2001 Feb; 114(Pt 3):539-47. PMID: 11171323.
      Citations:    
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