Thomas Jefferson University

Howard Gamper Jr

TitleAsst Professor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address233 S. 10th Street
Philadelphia PA 19107
Phone215-503-9798
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    R44AI025266     (GAMPER, HOWARD BYRON)Sep 1, 1987 - Aug 31, 1992
    NIH
    SYNTHETIC OLIGONUCLEOTIDES FOR TRYPANOSOME CHEMOTHERAPY
    Role: Principal Investigator
    R43AI031315     (GAMPER, HOWARD BYRON)Apr 1, 1991 - Sep 30, 1991
    NIH
    HIV REPORTER CELL LINE FOR SCREENING ANTI-SENSE AGENTS
    Role: Principal Investigator
    R43AI031007     (GAMPER, HOWARD BYRON)Aug 1, 1991 - Jul 31, 1992
    NIH
    ANTI SENSE INHIBITION OF HBSAG EXPRESSION IN HEP G2 CELL
    Role: Principal Investigator
    R42GM074564     (GAMPER, HOWARD BYRON)Jul 1, 2005 - Jun 30, 2008
    NIH
    Reagents for Preparing Structure-Free DNA and RNA
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nakano Y, Gamper H, McGuigan H, Maharjan S, Li J, Sun Z, Yigit E, Gr?nberg S, Krishnan K, Li NS, Piccirilli JA, Kleiner R, Nichols N, Gregory BD, Hou YM. Genome-wide profiling of tRNA modifications by Induro-tRNAseq reveals coordinated changes. Nat Commun. 2025 Jan 26; 16(1):1047. PMID: 39865096.
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    2. Fanari O, Tavakoli S, Qiu Y, Makhamreh A, Nian K, Akeson S, Meseonznik M, McCormick CA, Bloch D, Gamper H, Jain M, Hou YM, Wanunu M, Rouhanifard SH. Probing enzyme-dependent pseudouridylation using direct RNA sequencing to assess neuronal epitranscriptome plasticity. bioRxiv. 2024 Nov 26. PMID: 38585714.
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    3. Maharjan S, Gamper H, Yamaki Y, Christian T, Henley RY, Li NS, Suzuki T, Suzuki T, Piccirilli JA, Wanunu M, Seifert E, Wallace DC, Hou YM. Post-transcriptional methylation of mitochondrial-tRNA differentially contributes to mitochondrial pathology. Nat Commun. 2024 10 18; 15(1):9008. PMID: 39424798.
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    4. Makhamreh A, Tavakoli S, Fallahi A, Kang X, Gamper H, Nabizadehmashhadtoroghi M, Jain M, Hou YM, Rouhanifard SH, Wanunu M. Nanopore signal deviations from pseudouridine modifications in RNA are sequence-specific: quantification requires dedicated synthetic controls. Sci Rep. 2024 09 28; 14(1):22457. PMID: 39341872.
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    5. Namani S, Kavetsky K, Lin CY, Maharjan S, Gamper HB, Li NS, Piccirilli JA, Hou YM, Drndic M. Unraveling RNA Conformation Dynamics in Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episode Syndrome with Solid-State Nanopores. ACS Nano. 2024 07 02; 18(26):17240-17250. PMID: 38906834.
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    6. Maharjan S, Gamper H, Yamaki Y, Henley RY, Li NS, Suzuki T, Suzuki T, Piccirilli JA, Wanunu M, Seifert E, Wallace DC, Hou YM. Post-Transcriptional Methylation of Mitochondrial-tRNA Differentially Contributes to Mitochondrial Pathology. bioRxiv. 2023 Dec 10. PMID: 38106193.
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    7. Nakano Y, Gamper H, McGuigan H, Maharjan S, Sun Z, Krishnan K, Yigit E, Li NS, Piccirilli JA, Kleiner R, Nichols N, Hou YM. Genome-Wide Profiling of tRNA Using an Unexplored Reverse Transcriptase with High Processivity. bioRxiv. 2023 Dec 09. PMID: 38106225.
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    8. Li Y, Majumdar S, Treen R, Sharma MR, Corro J, Gamper HB, Manjari SR, Prusa J, Banavali NK, Stallings CL, Hou YM, Agrawal RK, Ojha AK. Starvation sensing by mycobacterial RelA/SpoT homologue through constitutive surveillance of translation. Proc Natl Acad Sci U S A. 2023 05 30; 120(22):e2302006120. PMID: 37216503.
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    9. Gamper H, McCormick C, Makhamreh A, Wanunu M, Rouhanifard SH, Hou YM. Enzymatic synthesis of RNA standards for mapping and quantifying RNA modifications in sequencing analysis. Methods Enzymol. 2023; 692:127-153. PMID: 37925177.
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    10. Tavakoli S, Nabizadeh M, Makhamreh A, Gamper H, McCormick CA, Rezapour NK, Hou YM, Wanunu M, Rouhanifard SH. Semi-quantitative detection of pseudouridine modifications and type I/II hypermodifications in human mRNAs using direct long-read sequencing. Nat Commun. 2023 01 19; 14(1):334. PMID: 36658122.
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    11. Yamaki Y, Gamper H, Hou YM. Synthesis of Stably Charged Arg-tRNAArg for Structural Analysis. Methods Mol Biol. 2023; 2620:263-271. PMID: 37010769.
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    12. Avcilar-Kucukgoze I, Gamper H, Hou YM, Kashina AS. Preparation of an Enriched tRNAArg Fraction for Arginylation by Expression in E. coli. Methods Mol Biol. 2023; 2620:101-106. PMID: 37010754.
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    13. Cui Z, Li X, Shin J, Gamper H, Hou YM, Sacchettini JC, Zhang J. Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Nat Commun. 2022 01 21; 13(1):432. PMID: 35064151.
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    14. Gamper H, Masuda I, Hou YM. Genome Expansion by tRNA +1 Frameshifting at Quadruplet Codons. J Mol Biol. 2022 04 30; 434(8):167440. PMID: 34995554.
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    15. Carbone CE, Loveland AB, Gamper HB, Hou YM, Demo G, Korostelev AA. Time-resolved cryo-EM visualizes ribosomal translocation with EF-G and GTP. Nat Commun. 2021 12 13; 12(1):7236. PMID: 34903725.
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    16. Gamper H, Mao Y, Masuda I, McGuigan H, Blaha G, Wang Y, Xu S, Hou YM. Twice exploration of tRNA?+1 frameshifting in an elongation cycle of protein synthesis. Nucleic Acids Res. 2021 09 27; 49(17):10046-10060. PMID: 34417618.
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    17. Masuda I, Hwang JY, Christian T, Maharjan S, Mohammad F, Gamper H, Buskirk AR, Hou YM. Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression. Elife. 2021 08 12; 10. PMID: 34382933.
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    18. Demo G, Gamper HB, Loveland AB, Masuda I, Carbone CE, Svidritskiy E, Hou YM, Korostelev AA. Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation. Nat Commun. 2021 07 30; 12(1):4644. PMID: 34330903.
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    19. Gamper H, Li H, Masuda I, Miklos Robkis D, Christian T, Conn AB, Blaha G, Petersson EJ, Gonzalez RL, Hou YM. Insights into genome recoding from the mechanism of a classic +1-frameshifting tRNA. Nat Commun. 2021 01 12; 12(1):328. PMID: 33436566.
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    20. Avcilar-Kucukgoze I, Gamper H, Hou YM, Kashina A. Purification and Use of tRNA for Enzymatic Post-translational Addition of Amino Acids to Proteins. STAR Protoc. 2020 12 18; 1(3):100207. PMID: 33377101.
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    21. Gamper H, Hou YM. A Label-Free Assay for Aminoacylation of tRNA. Genes (Basel). 2020 10 07; 11(10). PMID: 33036365.
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    22. Avcilar-Kucukgoze I, Gamper H, Polte C, Ignatova Z, Kraetzner R, Shtutman M, Hou YM, Dong DW, Kashina A. tRNAArg-Derived Fragments Can Serve as Arginine Donors for Protein Arginylation. Cell Chem Biol. 2020 07 16; 27(7):839-849.e4. PMID: 32553119.
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    23. Hou YM, Masuda I, Gamper H. Codon-Specific Translation by m1G37 Methylation of tRNA. Front Genet. 2018; 9:713. PMID: 30687389.
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    24. Naganuma M, Sekine SI, Chong YE, Guo M, Yang XL, Gamper H, Hou YM, Schimmel P, Yokoyama S. Author Correction: The selective tRNA aminoacylation mechanism based on a single G?U pair. Nature. 2018 12; 564(7736):E37. PMID: 30459470.
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    25. Gamper H, Hou YM. tRNA 3'-amino-tailing for stable amino acid attachment. RNA. 2018 12; 24(12):1878-1885. PMID: 30217865.
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    26. Masuda I, Takase R, Matsubara R, Paulines MJ, Gamper H, Limbach PA, Hou YM. Selective terminal methylation of a tRNA wobble base. Nucleic Acids Res. 2018 04 20; 46(7):e37. PMID: 29361055.
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    27. Fan H, Conn AB, Williams PB, Diggs S, Hahm J, Gamper HB, Hou YM, O'Leary SE, Wang Y, Blaha GM. Transcription-translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits. Nucleic Acids Res. 2017 Nov 02; 45(19):11043-11055. PMID: 28977553.
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    28. Po P, Delaney E, Gamper H, Szantai-Kis DM, Speight L, Tu L, Kosolapov A, Petersson EJ, Hou YM, Deutsch C. Effect of Nascent Peptide Steric Bulk on Elongation Kinetics in the Ribosome Exit Tunnel. J Mol Biol. 2017 06 16; 429(12):1873-1888. PMID: 28483649.
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    29. Masuda I, Igarashi T, Sakaguchi R, Nitharwal RG, Takase R, Han KY, Leslie BJ, Liu C, Gamper H, Ha T, Sanyal S, Hou YM. A genetically encoded fluorescent tRNA is active in live-cell protein synthesis. Nucleic Acids Res. 2017 04 20; 45(7):4081-4093. PMID: 27956502.
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    30. Falk MJ, Gai X, Shigematsu M, Vilardo E, Takase R, McCormick E, Christian T, Place E, Pierce EA, Consugar M, Gamper HB, Rossmanith W, Hou YM. A novel HSD17B10 mutation impairing the activities of the mitochondrial RNase P complex causes X-linked intractable epilepsy and neurodevelopmental regression. RNA Biol. 2016 05 03; 13(5):477-85. PMID: 26950678.
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    31. Gamper HB, Masuda I, Frenkel-Morgenstern M, Hou YM. The UGG Isoacceptor of tRNAPro Is Naturally Prone to Frameshifts. Int J Mol Sci. 2015 Jul 01; 16(7):14866-83. PMID: 26140378.
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    32. Gamper HB, Masuda I, Frenkel-Morgenstern M, Hou YM. Maintenance of protein synthesis reading frame by EF-P and m(1)G37-tRNA. Nat Commun. 2015 May 26; 6:7226. PMID: 26009254.
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    33. Hou YM, Gamper H, Yang W. Post-transcriptional modifications to tRNA--a response to the genetic code degeneracy. RNA. 2015 Apr; 21(4):642-4. PMID: 25780173.
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    34. Simons C, Griffin LB, Helman G, Golas G, Pizzino A, Bloom M, Murphy JL, Crawford J, Evans SH, Topper S, Whitehead MT, Schreiber JM, Chapman KA, Tifft C, Lu KB, Gamper H, Shigematsu M, Taft RJ, Antonellis A, Hou YM, Vanderver A. Loss-of-function alanyl-tRNA synthetase mutations cause an autosomal-recessive early-onset epileptic encephalopathy with persistent myelination defect. Am J Hum Genet. 2015 Apr 02; 96(4):675-81. PMID: 25817015.
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    35. Sakaguchi R, Lahoud G, Christian T, Gamper H, Hou YM. A divalent metal ion-dependent N(1)-methyl transfer to G37-tRNA. Chem Biol. 2014 Oct 23; 21(10):1351-1360. PMID: 25219964.
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    36. Naganuma M, Sekine S, Chong YE, Guo M, Yang XL, Gamper H, Hou YM, Schimmel P, Yokoyama S. The selective tRNA aminoacylation mechanism based on a single G?U pair. Nature. 2014 Jun 26; 510(7506):507-11. PMID: 24919148.
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    37. Peacock JR, Walvoord RR, Chang AY, Kozlowski MC, Gamper H, Hou YM. Amino acid-dependent stability of the acyl linkage in aminoacyl-tRNA. RNA. 2014 Jun; 20(6):758-64. PMID: 24751649.
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    38. Masuda I, Sakaguchi R, Liu C, Gamper H, Hou YM. The temperature sensitivity of a mutation in the essential tRNA modification enzyme tRNA methyltransferase D (TrmD). J Biol Chem. 2013 Oct 04; 288(40):28987-96. PMID: 23986443.
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    39. Christian T, Gamper H, Hou YM. Conservation of structure and mechanism by Trm5 enzymes. RNA. 2013 Sep; 19(9):1192-9. PMID: 23887145.
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    40. Rodriguez-Hernandez A, Spears JL, Gaston KW, Limbach PA, Gamper H, Hou YM, Kaiser R, Agris PF, Perona JJ. Structural and mechanistic basis for enhanced translational efficiency by 2-thiouridine at the tRNA anticodon wobble position. J Mol Biol. 2013 Oct 23; 425(20):3888-906. PMID: 23727144.
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    41. Liu C, Gamper H, Liu H, Cooperman BS, Hou YM. Potential for interdependent development of tRNA determinants for aminoacylation and ribosome decoding. Nat Commun. 2011; 2:329. PMID: 21629262.
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    42. Kim S, Liu C, Halkidis K, Gamper HB, Hou YM. Distinct kinetic determinants for the stepwise CCA addition to tRNA. RNA. 2009 Oct; 15(10):1827-36. PMID: 19696158.
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    43. Lahoud G, Timoshchuk V, Lebedev A, Arar K, Hou YM, Gamper H. Properties of pseudo-complementary DNA substituted with weakly pairing analogs of guanine or cytosine. Nucleic Acids Res. 2008 Dec; 36(22):6999-7008. PMID: 18987000.
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    44. Lahoud G, Arar K, Hou YM, Gamper H. RecA-mediated strand invasion of DNA by oligonucleotides substituted with 2-aminoadenine and 2-thiothymine. Nucleic Acids Res. 2008 Dec; 36(21):6806-15. PMID: 18953036.
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    45. Zhang CM, Liu C, Christian T, Gamper H, Rozenski J, Pan D, Randolph JB, Wickstrom E, Cooperman BS, Hou YM. Pyrrolo-C as a molecular probe for monitoring conformations of the tRNA 3' end. RNA. 2008 Oct; 14(10):2245-53. PMID: 18755841.
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    46. Lahoud G, Timoshchuk V, Lebedev A, de Vega M, Salas M, Arar K, Hou YM, Gamper H. Enzymatic synthesis of structure-free DNA with pseudo-complementary properties. Nucleic Acids Res. 2008 Jun; 36(10):3409-19. PMID: 18448471.
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    47. Dupasquier M, Kim S, Halkidis K, Gamper H, Hou YM. tRNA integrity is a prerequisite for rapid CCA addition: implication for quality control. J Mol Biol. 2008 Jun 06; 379(3):579-88. PMID: 18466919.
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    48. Betteridge T, Liu H, Gamper H, Kirillov S, Cooperman BS, Hou YM. Fluorescent labeling of tRNAs for dynamics experiments. RNA. 2007 Sep; 13(9):1594-601. PMID: 17652134.
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    49. Liu C, Gamper H, Shtivelband S, Hauenstein S, Perona JJ, Hou YM. Kinetic quality control of anticodon recognition by a eukaryotic aminoacyl-tRNA synthetase. J Mol Biol. 2007 Apr 06; 367(4):1063-78. PMID: 17303165.
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    50. Gamper HB, Arar K, Gewirtz A, Hou YM. Unrestricted hybridization of oligonucleotides to structure-free DNA. Biochemistry. 2006 Jun 06; 45(22):6978-86. PMID: 16734433.
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    51. Hou YM, Li Z, Gamper H. Isolation of a site-specifically modified RNA from an unmodified transcript. Nucleic Acids Res. 2006 Feb 10; 34(3):e21. PMID: 16473844.
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    52. Gamper HB, Arar K, Gewirtz A, Hou YM. Unrestricted accessibility of short oligonucleotides to RNA. RNA. 2005 Sep; 11(9):1441-7. PMID: 16120834.
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    53. Gamper HB, Gewirtz A, Edwards J, Hou YM. Modified bases in RNA reduce secondary structure and enhance hybridization. Biochemistry. 2004 Aug 10; 43(31):10224-36. PMID: 15287750.
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    54. Gamper HB, Nulf CJ, Corey DR, Kmiec EB. The synaptic complex of RecA protein participates in hybridization and inverse strand exchange reactions. Biochemistry. 2003 Mar 11; 42(9):2643-55. PMID: 12614159.
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    55. Agarwal S, Gamper HB, Kmiec EB. Nucleotide replacement at two sites can be directed by modified single-stranded oligonucleotides in vitro and in vivo. Biomol Eng. 2003 Jan; 20(1):7-20. PMID: 12485680.
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    56. Liu L, Rice MC, Drury M, Cheng S, Gamper H, Kmiec EB. Strand bias in targeted gene repair is influenced by transcriptional activity. Mol Cell Biol. 2002 Jun; 22(11):3852-63. PMID: 11997519.
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    57. Gamper HB, Hou YM, Kmiec EB. Evidence for a four-strand exchange catalyzed by the RecA protein. Biochemistry. 2000 Dec 12; 39(49):15272-81. PMID: 11106508.
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    58. Gamper HB, Parekh H, Rice MC, Bruner M, Youkey H, Kmiec EB. The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts. Nucleic Acids Res. 2000 Nov 01; 28(21):4332-9. PMID: 11058133.
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    59. Gamper HB, Cole-Strauss A, Metz R, Parekh H, Kumar R, Kmiec EB. A plausible mechanism for gene correction by chimeric oligonucleotides. Biochemistry. 2000 May 16; 39(19):5808-16. PMID: 10801331.
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    60. Gamper HB, Afonina I, Belousov E, Reed MW, Podyminogin MA. Use of quantitative ligation-mediated polymerase chain reaction to detect gene targeting by alkylating oligodeoxynucleotides. Methods Mol Biol. 2000; 133:201-11. PMID: 10561840.
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    61. Singer MJ, Podyminogin MA, Metcalf MA, Reed MW, Brown DA, Gamper HB, Meyer RB, Wydro RM. Targeted mutagenesis of DNA with alkylating RecA assisted oligonucleotides. Nucleic Acids Res. 1999 Dec 15; 27(24):e38. PMID: 10572190.
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    62. Compagno D, Lampe JN, Bourget C, Kutyavin IV, Yurchenko L, Lukhtanov EA, Gorn VV, Gamper HB, Toulm? JJ. Antisense oligonucleotides containing modified bases inhibit in vitro translation of Leishmania amazonensis mRNAs by invading the mini-exon hairpin. J Biol Chem. 1999 Mar 19; 274(12):8191-8. PMID: 10075723.
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    63. Cole-Strauss A, Gamper H, Holloman WK, Mu?oz M, Cheng N, Kmiec EB. Targeted gene repair directed by the chimeric RNA/DNA oligonucleotide in a mammalian cell-free extract. Nucleic Acids Res. 1999 Mar 01; 27(5):1323-30. PMID: 9973621.
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    64. Ebbinghaus SW, Fortinberry H, Gamper HB. Inhibition of transcription elongation in the HER-2/neu coding sequence by triplex-directed covalent modification of the template strand. Biochemistry. 1999 Jan 12; 38(2):619-28. PMID: 9888801.
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    65. Belousov ES, Afonina IA, Kutyavin IV, Gall AA, Reed MW, Gamper HB, Wydro RM, Meyer RB. Triplex targeting of a native gene in permeabilized intact cells: covalent modification of the gene for the chemokine receptor CCR5. Nucleic Acids Res. 1998 Mar 01; 26(5):1324-8. PMID: 9469844.
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    66. Kumar S, Reed MW, Gamper HB, Gorn VV, Lukhtanov EA, Foti M, West J, Meyer RB, Schweitzer BI. Solution structure of a highly stable DNA duplex conjugated to a minor groove binder. Nucleic Acids Res. 1998 Feb 01; 26(3):831-8. PMID: 9443977.
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    67. Gamper HB, Kutyavin IV, Rhinehart RL, Lokhov SG, Reed MW, Meyer RB. Modulation of Cm/T, G/A, and G/T triplex stability by conjugate groups in the presence and absence of KCl. Biochemistry. 1997 Dec 02; 36(48):14816-26. PMID: 9398203.
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    68. Lampe JN, Kutyavin IV, Rhinehart R, Reed MW, Meyer RB, Gamper HB. Factors influencing the extent and selectivity of alkylation within triplexes by reactive G/A motif oligonucleotides. Nucleic Acids Res. 1997 Oct 15; 25(20):4123-31. PMID: 9321668.
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    69. Kutyavin IV, Lukhtanov EA, Gamper HB, Meyer RB. Oligonucleotides with conjugated dihydropyrroloindole tripeptides: base composition and backbone effects on hybridization. Nucleic Acids Res. 1997 Sep 15; 25(18):3718-23. PMID: 9278496.
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    70. Belousov ES, Afonina IA, Podyminogin MA, Gamper HB, Reed MW, Wydro RM, Meyer RB. Sequence-specific targeting and covalent modification of human genomic DNA. Nucleic Acids Res. 1997 Sep 01; 25(17):3440-4. PMID: 9254701.
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    71. Afonina I, Zivarts M, Kutyavin I, Lukhtanov E, Gamper H, Meyer RB. Efficient priming of PCR with short oligonucleotides conjugated to a minor groove binder. Nucleic Acids Res. 1997 Jul 01; 25(13):2657-60. PMID: 9185578.
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    72. Hou YM, Gamper HB. Inhibition of tRNA aminoacylation by 2'-O-methyl oligonucleotides. Biochemistry. 1996 Dec 03; 35(48):15340-8. PMID: 8952485.
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    73. Kutyavin IV, Rhinehart RL, Lukhtanov EA, Gorn VV, Meyer RB, Gamper HB. Oligonucleotides containing 2-aminoadenine and 2-thiothymine act as selectively binding complementary agents. Biochemistry. 1996 Aug 27; 35(34):11170-6. PMID: 8780521.
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    74. Woo J, Meyer RB, Gamper HB. G/C-modified oligodeoxynucleotides with selective complementarity: synthesis and hybridization properties. Nucleic Acids Res. 1996 Jul 01; 24(13):2470-5. PMID: 8692683.
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    75. Podyminogin MA, Meyer RB, Gamper HB. RecA-catalyzed, sequence-specific alkylation of DNA by cross-linking oligonucleotides. Effects of length and nonhomologous base substitutions. Biochemistry. 1996 Jun 04; 35(22):7267-74. PMID: 8679556.
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    76. Afonina I, Kutyavin I, Lukhtanov E, Meyer RB, Gamper H. Sequence-specific arrest of primer extension on single-stranded DNA by an oligonucleotide-minor groove binder conjugate. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3199-204. PMID: 8622913.
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    77. Lukhtanov EA, Podyminogin MA, Kutyavin IV, Meyer RB, Gamper HB. Rapid and efficient hybridization-triggered crosslinking within a DNA duplex by an oligodeoxyribonucleotide bearing a conjugated cyclopropapyrroloindole. Nucleic Acids Res. 1996 Feb 15; 24(4):683-7. PMID: 8604310.
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    78. Podyminogin MA, Meyer RB, Gamper HB. Sequence-specific covalent modification of DNA by cross-linking oligonucleotides. Catalysis by RecA and implication for the mechanism of synaptic joint formation. Biochemistry. 1995 Oct 10; 34(40):13098-108. PMID: 7548070.
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    79. Zhou JH, Pai BS, Reed MW, Gamper HB, Lukhtanov E, Podyminogin M, Meyer RB, Cheng YC. Discovery of short, 3'-cholesterol-modified DNA duplexes with unique antitumor cell activity. Cancer Res. 1994 Nov 15; 54(22):5783-7. PMID: 7954399.
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    80. Tabone JC, Stamm MR, Gamper HB, Meyer RB. Factors influencing the extent and regiospecificity of cross-link formation between single-stranded DNA and reactive complementary oligodeoxynucleotides. Biochemistry. 1994 Jan 11; 33(1):375-83. PMID: 8286359.
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    81. Gamper HB, Reed MW, Cox T, Virosco JS, Adams AD, Gall AA, Scholler JK, Meyer RB. Facile preparation of nuclease resistant 3' modified oligodeoxynucleotides. Nucleic Acids Res. 1993 Jan 11; 21(1):145-50. PMID: 8382790.
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    82. Piette J, Gamper HB, van de Vorst A, Hearst JE. Mutagenesis induced by site specifically placed 4'-hydroxymethyl-4,5',8-trimethylpsoralen adducts. Nucleic Acids Res. 1988 Nov 11; 16(21):9961-77. PMID: 3057451.
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    83. Cheng S, Van Houten B, Gamper HB, Sancar A, Hearst JE. Use of psoralen-modified oligonucleotides to trap three-stranded RecA-DNA complexes and repair of these cross-linked complexes by ABC excinuclease. J Biol Chem. 1988 Oct 15; 263(29):15110-7. PMID: 2844801.
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    84. Shi YB, Griffith J, Gamper H, Hearst JE. Evidence for structural deformation of the DNA helix by a psoralen diadduct but not by a monoadduct. Nucleic Acids Res. 1988 Sep 26; 16(18):8945-52. PMID: 3174437.
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    85. Kodadek T, Gamper H. Efficient synthesis of a supercoiled M13 DNA molecule containing a site specifically placed psoralen adduct and its use as a substrate for DNA replication. Biochemistry. 1988 May 03; 27(9):3210-5. PMID: 3291944.
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    86. Shi YB, Gamper H, Van Houten B, Hearst JE. Interaction of Escherichia coli RNA polymerase with DNA in an elongation complex arrested at a specific psoralen crosslink site. J Mol Biol. 1988 Jan 20; 199(2):277-93. PMID: 3280804.
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    87. Shi YB, Gamper H, Hearst JE. Interaction of T7 RNA polymerase with DNA in an elongation complex arrested at a specific psoralen adduct site. J Biol Chem. 1988 Jan 05; 263(1):527-34. PMID: 3275650.
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    88. Van Houten B, Gamper H, Sancar A, Hearst JE. DNase I footprint of ABC excinuclease. J Biol Chem. 1987 Sep 25; 262(27):13180-7. PMID: 3308871.
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    89. Gamper HB, Cimino GD, Hearst JE. Solution hybridization of crosslinkable DNA oligonucleotides to bacteriophage M13 DNA. Effect of secondary structure on hybridization kinetics and equilibria. J Mol Biol. 1987 Sep 20; 197(2):349-62. PMID: 3316669.
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    90. Shi YB, Gamper H, Hearst JE. The effects of covalent additions of a psoralen on transcription by E. coli RNA polymerase. Nucleic Acids Res. 1987 Sep 11; 15(17):6843-54. PMID: 3309888.
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    91. Gamper HB, Cimino GD, Isaacs ST, Ferguson M, Hearst JE. Reverse Southern hybridization. Nucleic Acids Res. 1986 Dec 22; 14(24):9943-54. PMID: 3808957.
      Citations:    
    92. Van Houten B, Gamper H, Holbrook SR, Hearst JE, Sancar A. Action mechanism of ABC excision nuclease on a DNA substrate containing a psoralen crosslink at a defined position. Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8077-81. PMID: 3534882.
      Citations:    
    93. Van Houten B, Gamper H, Hearst JE, Sancar A. Construction of DNA substrates modified with psoralen at a unique site and study of the action mechanism of ABC excinuclease on these uniformly modified substrates. J Biol Chem. 1986 Oct 25; 261(30):14135-41. PMID: 3021728.
      Citations:    
    94. Cimino GD, Gamper HB, Isaacs ST, Hearst JE. Psoralens as photoactive probes of nucleic acid structure and function: organic chemistry, photochemistry, and biochemistry. Annu Rev Biochem. 1985; 54:1151-93. PMID: 2411210.
      Citations:    
    95. Gamper HB, Hearst JE. Size of the unwound region of DNA in Escherichia coli RNA polymerase and calf thymus RNA polymerase II ternary complexes. Cold Spring Harb Symp Quant Biol. 1983; 47 Pt 1:455-61. PMID: 6345062.
      Citations:    
    96. Gamper HB, Hearst JE. A topological model for transcription based on unwinding angle analysis of E. coli RNA polymerase binary, initiation and ternary complexes. Cell. 1982 May; 29(1):81-90. PMID: 6286146.
      Citations:    
    97. Gamper HB, Bartholomew JC, Calvin M. Mechanism of benzo[a]pyrene diol epoxide induced deoxyribonucleic acid strand scission. Biochemistry. 1980 Aug 19; 19(17):3948-56. PMID: 6250579.
      Citations:    
    98. Gamper HB, Tung AS, Straub K, Bartholomew JC, Calvin M. DNA strand scission by benzo[a]pyrene diol epoxides. Science. 1977 Aug 12; 197(4304):671-4. PMID: 877583.
      Citations:    
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