Janice Walker

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentAnatomy
Address1020 Locust St.
Philadelphia PA 19107
Phone215-503-5903
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    F32GM065031     (WALKER, JANICE L)Jan 4, 2002 - Jan 3, 2005
    NIH
    Integrin-mediated repression of the p21 CIPI promoter
    Role: Principal Investigator

    R21EY019571     (WALKER, JANICE LYNN)Aug 1, 2009 - Jul 31, 2012
    NIH
    The Stem Cell Niche and Lens Fibrotic Disease
    Role: Principal Investigator

    R21DE024954     (KUKURUZINSKA, MARIA A)Jul 1, 2015 - Jun 30, 2018
    NIH
    Repair, Regeneration and Fibrosis of the Salivary Gland
    Role: Co-Principal Investigator

    R01EY026159     (WALKER, JANICE LYNN)Apr 1, 2017 - Mar 31, 2021
    NIH
    Structure of post-replicative chromatin during cell reprogramming in fibrotic disease
    Role: Principal Investigator

    R01EY035771     (WALKER, JANICE LYNN)Apr 1, 2024 - Mar 31, 2029
    NIH
    Molecular function of extracellular vimentin in regulating the response to lens wounding
    Role: Principal Investigator

    R21EY035462     (WALKER, JANICE LYNN)Jun 1, 2024 - May 31, 2026
    NIH
    Investigating the role of mitochondrial function in driving lens fibrotic disease
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. DeDreu J, Basta MD, Walker JL, Menko AS. Immune Responses Induced at One Hour Post Cataract Surgery Wounding of the Chick Lens. Biomolecules. 2023 Nov 04; 13(11). PMID: 38002297.
      Citations:    
    2. Basta MD, Petruk S, Mazo A, Walker JL. Fibrosis-the tale of H3K27 histone methyltransferases and demethylases. Front Cell Dev Biol. 2023; 11:1193344. PMID: 37476157.
      Citations:    
    3. Basta MD, Petruk S, Summer R, Rosenbloom J, Wermuth PJ, Macarak E, Levin AV, Mazo A, Walker JL. Changes in nascent chromatin structure regulate activation of the pro-fibrotic transcriptome and myofibroblast emergence in organ fibrosis. iScience. 2023 May 19; 26(5):106570. PMID: 37250334.
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    4. Basta MD, Menko AS, Walker JL. PI3K Isoform-Specific Regulation of Leader and Follower Cell Function for Collective Migration and Proliferation in Response to Injury. Cells. 2022 11 07; 11(21). PMID: 36359913.
      Citations:    
    5. Menko AS, Walker JL. The Pro-Fibrotic Response to Lens Injury Is Signaled in a PI3K Isoform-Specific Manner. Biomolecules. 2022 08 25; 12(9). PMID: 36139020.
      Citations:    
    6. Menko AS, Romisher A, Walker JL. The Pro-fibrotic Response of Mesenchymal Leader Cells to Lens Wounding Involves Hyaluronic Acid, Its Receptor RHAMM, and Vimentin. Front Cell Dev Biol. 2022; 10:862423. PMID: 35386200.
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    7. Basta MD, Paulson H, Walker JL. The local wound environment is a key determinant of the outcome of TGFß signaling on the fibrotic response of CD44+ leader cells in an ex vivo post-cataract-surgery model. Exp Eye Res. 2021 12; 213:108829. PMID: 34774488.
      Citations:    
    8. Walker JL, Menko AS. Immune cells in lens injury repair and fibrosis. Exp Eye Res. 2021 Jun 11; 209:108664. PMID: 34126081.
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    9. Menko AS, DeDreu J, Logan CM, Paulson H, Levin AV, Walker JL. Resident immune cells of the avascular lens: Mediators of the injury and fibrotic response of the lens. FASEB J. 2021 Apr; 35(4):e21341. PMID: 33710665.
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    10. Walker JL, Wang W, Lin E, Romisher A, Bouchie MP, Bleaken B, Menko AS, Kukuruzinska MA. Specification of the patterning of a ductal tree during branching morphogenesis of the submandibular gland. Sci Rep. 2021 Jan 11; 11(1):330. PMID: 33432003.
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    11. DeDreu J, Walker JL, Menko AS. Dynamics of the lens basement membrane capsule and its interaction with connective tissue-like extracapsular matrix proteins. Matrix Biol. 2020 Dec 28. PMID: 33383103.
      Citations:    
    12. Menko AS, Walker JL, Stepp MA. Fibrosis: Shared lessons from the lens and cornea. Anat Rec (Hoboken). 2019 Feb 15. PMID: 30768772.
      Citations:    
    13. Bleaken BM, Menko AS, Walker JL. Cells activated for wound repair have the potential to direct collective invasion of an epithelium. Mol Biol Cell. 2016 Feb 1; 27(3):451-65. PMID: 26658613.
      Citations:    
    14. Walker JL, Bleaken BM, Wolff IM, Menko AS. Establishment of a Clinically Relevant Ex Vivo Mock Cataract Surgery Model for Investigating Epithelial Wound Repair in a Native Microenvironment. J Vis Exp. 2015; (100). PMID: 26132117.
      Citations:    
    15. Walker JL, Zhai N, Zhang L, Bleaken BM, Wolff I, Gerhart J, George-Weinstein M, Menko AS. Unique precursors for the mesenchymal cells involved in injury response and fibrosis. Proc Natl Acad Sci U S A. 2010 Aug 3; 107(31):13730-5. PMID: 20634425.
      Citations:    
    16. Walker JL, Menko AS, Khalil S, Rebustini I, Hoffman MP, Kreidberg JA, Kukuruzinska MA. Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures. Dev Dyn. 2008 Nov; 237(11):3128-41. PMID: 18816447.
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    17. Yung Y, Walker JL, Roberts JM, Assoian RK. A Skp2 autoinduction loop and restriction point control. J Cell Biol. 2007 Aug 27; 178(5):741-7. PMID: 17724117.
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    18. Walker JL, Wolff IM, Zhang L, Menko AS. Activation of SRC kinases signals induction of posterior capsule opacification. Invest Ophthalmol Vis Sci. 2007 May; 48(5):2214-23. PMID: 17460282.
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    19. Villanueva J, Yung Y, Walker JL, Assoian RK. ERK activity and G1 phase progression: identifying dispensable versus essential activities and primary versus secondary targets. Mol Biol Cell. 2007 Apr; 18(4):1457-63. PMID: 17314399.
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    20. Walker JL, Assoian RK. Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression. Cancer Metastasis Rev. 2005 Sep; 24(3):383-93. PMID: 16258726.
      Citations:    
    21. Walker JL, Fournier AK, Assoian RK. Regulation of growth factor signaling and cell cycle progression by cell adhesion and adhesion-dependent changes in cellular tension. Cytokine Growth Factor Rev. 2005 Aug-Oct; 16(4-5):395-405. PMID: 15886049.
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    22. Walker JL, Zhang L, Menko AS. A signaling role for the uncleaved form of alpha 6 integrin in differentiating lens fiber cells. Dev Biol. 2002 Nov 15; 251(2):195-205. PMID: 12435352.
      Citations:    
    23. Walker JL, Zhang L, Menko AS. Transition between proliferation and differentiation for lens epithelial cells is regulated by Src family kinases. Dev Dyn. 2002 Aug; 224(4):361-72. PMID: 12203728.
      Citations:    
    24. Walker JL, Zhang L, Zhou J, Woolkalis MJ, Menko AS. Role for alpha 6 integrin during lens development: Evidence for signaling through IGF-1R and ERK. Dev Dyn. 2002 Mar; 223(2):273-84. PMID: 11836791.
      Citations:    
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