Thomas Jefferson University

Linda Siracusa

TitleAdjunct Faculty
InstitutionThomas Jefferson University
DepartmentJefferson College of Life Scie
Address1020 Locust St.
Philadelphia PA 19107
Phone215-503-4536
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    F32GM012721     (SIRACUSA, LINDA D)Feb 28, 1989
    NIH
    CLONING OF THE AGOUTI LOCUS IN THE MOUSE
    Role: Principal Investigator
    R01DK045717     (SIRACUSA, LINDA D)Mar 1, 1993 - Feb 28, 1998
    NIH
    MOLECULAR CHARACTERIZATION OF THE AGOUTI REGION
    Role: Principal Investigator
    R01CA089560     (SIRACUSA, LINDA D)Feb 1, 2003 - Jan 31, 2009
    NIH
    Molecular Genetics of Cancer Susceptibility
    Role: Principal Investigator
    R01CA120243     (SIRACUSA, LINDA D)Jul 1, 2007 - May 31, 2013
    NIH
    Susceptibility Genes and Colorectal Cancer
    Role: Principal Investigator
    R21CA159860     (SIRACUSA, LINDA D)Mar 1, 2011 - Feb 28, 2014
    NIH
    Modifiers of Intestinal Tumor Progression
    Role: Principal Investigator
    R21CA169758     (SIRACUSA, LINDA D)Jul 9, 2012 - Jun 30, 2015
    NIH
    Use of Closely Related Inbred Strains to Identify Modifier Loci of Tumorigenesis
    Role: Principal Investigator
    R21CA202496     (SIRACUSA, LINDA D)Jul 1, 2016 - Dec 31, 2019
    NIH
    Using the Collaborative Cross for Model Studies of Intestinal Cancer
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Barratt KS, Dai Y, Miller DR, Gunn TM, Siracusa LD. 35th International Mammalian Genome Conference: meeting overview. Mamm Genome. 2023 Mar 03. PMID: 36867211.
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    2. Alugupalli KR, Kothari S, Cravens MP, Walker JA, Dougharty DT, Dickinson GS, Gatto LA, B?umler AJ, Wangdi T, Miller DR, Pardo-Manuel de Villena F, Siracusa LD. Identification of collaborative cross mouse strains permissive to Salmonella enterica serovar Typhi infection. Sci Rep. 2023 Jan 09; 13(1):393. PMID: 36624251.
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    3. Bukowiec L, Han Z, Terlecky SR, Grotheer K, Corse T, Coffin V, Siracusa LD. Leveraging the COVID-19 Research Spike to Provide Medical Students with Practical Experience in Data Appraisal and Grant Review. Med Sci Educ. 2022 Apr; 32(2):305-308. PMID: 35433108.
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    4. Bukowiec L, Coffin V, Siracusa LD, Zetkulic M. Bridging the preclinical-clinical divide in response to COVID-19. Med Educ. 2021 Nov; 55(11):1304-1305. PMID: 34414599.
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    5. Miller DR, Siracusa LD. 34th International mammalian genome conference: meeting overview. Mamm Genome. 2021 10; 32(5):319-322. PMID: 34091719.
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    6. Prasasya R, Grotheer KV, Siracusa LD, Bartolomei MS. Temple Syndrome and Kagami-Ogata Syndrome: Clinical Presentations, Genotypes, Models and Mechanisms. Hum Mol Genet. 2020 Jun 27. PMID: 32592473.
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    7. Cooper F, Overmiller AM, Loder A, Brennan-Crispi DM, McGuinn KP, Marous MR, Freeman TA, Riobo-Del Galdo NA, Siracusa LD, Wahl JK, Mahoney MG. Enhancement of Cutaneous Wound Healing by Dsg2 Augmentation of uPAR Secretion. J Invest Dermatol. 2018 May 09. PMID: 29753032.
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    8. Bussard KM, Siracusa LD. Understanding Mitochondrial Polymorphisms in Cancer. Cancer Res. 2017 Nov 15; 77(22):6051-6059. PMID: 29097610.
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    9. Siracusa LD, Bussard KM. The Clock Is Ticking: Countdown to Metastases. PLoS Genet. 2016 Sep; 12(9):e1006299. PMID: 27657702.
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    10. Barrington WT, Morgan AP, Siracusa LD. The 28th International Mammalian Genome Conference-meeting report. Mamm Genome. 2015 Jun; 26(5-6):201-9. PMID: 25899564.
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    11. Manne J, Markova M, Siracusa LD, Jimenez SA. Collagen content in skin and internal organs of the tight skin mouse: an animal model of scleroderma. Biochem Res Int. 2013; 2013:436053. PMID: 24260716.
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    12. Nnadi SC, Watson R, Innocent J, Gonye GE, Buchberg AM, Siracusa LD. Identification of five novel modifier loci of Apc(Min) harbored in the BXH14 recombinant inbred strain. Carcinogenesis. 2012 Aug; 33(8):1589-97. PMID: 22637734.
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    13. Serebrennikova OB, Tsatsanis C, Mao C, Gounaris E, Ren W, Siracusa LD, Eliopoulos AG, Khazaie K, Tsichlis PN. Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation. Proc Natl Acad Sci U S A. 2012 May 1; 109(18):E1082-91. PMID: 22451924.
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    14. Justice MJ, Siracusa LD, Stewart AF. Technical approaches for mouse models of human disease. Dis Model Mech. 2011 May; 4(3):305-10. PMID: 21558063.
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    15. Crist RC, Roth JJ, Lisanti MP, Siracusa LD, Buchberg AM. Identification of Mom12 and Mom13, two novel modifier loci of Apc (Min) -mediated intestinal tumorigenesis. Cell Cycle. 2011 Apr 1; 10(7):1092-9. PMID: 21386660.
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    16. Crist RC, Roth JJ, Baran AA, McEntee BJ, Siracusa LD, Buchberg AM. The armadillo repeat domain of Apc suppresses intestinal tumorigenesis. Mamm Genome. 2010 Oct; 21(9-10):450-7. PMID: 20886217.
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    17. Boman B, Kopelovich L, Siracusa LD, Zhang T, Henderson K, Cofer Z, Buchberg AM, Fields JZ, Otevrel T. A Tcf4-GFP reporter mouse model for monitoring effects of Apc mutations during intestinal tumorigenesis. Mol Carcinog. 2009 Sep; 48(9):821-31. PMID: 19263440.
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    18. Siracusa LD, Buchberg AM. The noncoding RNAs: a genomic symphony of transcripts. Mamm Genome. 2008 Aug; 19(7-8):449-53. PMID: 19011942.
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    19. Rossi S, Sevignani C, Nnadi SC, Siracusa LD, Calin GA. Cancer-associated genomic regions (CAGRs) and noncoding RNAs: bioinformatics and therapeutic implications. Mamm Genome. 2008 Aug; 19(7-8):526-40. PMID: 18636290.
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    20. Li P, Schulz S, Bombonati A, Palazzo JP, Hyslop TM, Xu Y, Baran AA, Siracusa LD, Pitari GM, Waldman SA. Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity. Gastroenterology. 2007 Aug; 133(2):599-607. PMID: 17681179.
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    21. Sevignani C, Calin GA, Nnadi SC, Shimizu M, Davuluri RV, Hyslop T, Demant P, Croce CM, Siracusa LD. MicroRNA genes are frequently located near mouse cancer susceptibility loci. Proc Natl Acad Sci U S A. 2007 May 8; 104(19):8017-22. PMID: 17470785.
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    22. Baran AA, Silverman KA, Zeskand J, Koratkar R, Palmer A, McCullen K, Curran WJ, Edmonston TB, Siracusa LD, Buchberg AM. The modifier of Min 2 (Mom2) locus: embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression. Genome Res. 2007 May; 17(5):566-76. PMID: 17387143.
      Citations:    
    23. Sevignani C, Calin GA, Siracusa LD, Croce CM. Mammalian microRNAs: a small world for fine-tuning gene expression. Mamm Genome. 2006 Mar; 17(3):189-202. PMID: 16518686.
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    24. Herron BJ, Liddell RA, Parker A, Grant S, Kinne J, Fisher JK, Siracusa LD. A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice. Nat Genet. 2005 Nov; 37(11):1210-2. PMID: 16200063.
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    25. Markova M, Koratkar RA, Silverman KA, Sollars VE, MacPhee-Pellini M, Walters R, Palazzo JP, Buchberg AM, Siracusa LD, Farber SA. Diversity in secreted PLA2-IIA activity among inbred mouse strains that are resistant or susceptible to Apc Min/+ tumorigenesis. Oncogene. 2005 Sep 22; 24(42):6450-8. PMID: 16007193.
      Citations:    
    26. Markova MS, Zeskand J, McEntee B, Rothstein J, Jimenez SA, Siracusa LD. A role for the androgen receptor in collagen content of the skin. J Invest Dermatol. 2004 Dec; 123(6):1052-6. PMID: 15610513.
      Citations:    
    27. Koratkar R, Silverman KA, Pequignot E, Hauck WW, Buchberg AM, Siracusa LD. Analysis of reciprocal congenic lines reveals the C3H/HeJ genome to be highly resistant to ApcMin intestinal tumorigenesis. Genomics. 2004 Nov; 84(5):844-52. PMID: 15475263.
      Citations:    
    28. Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G, Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Pan HJ, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K, Shou S, Sillanpää MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, Tarantino LM, Threadgill D, Toth LA, Valdar W, de Villena FP, Warden C, Whatley S, Williams RW, Wiltshire T, Yi N, Zhang D, Zhang M, Zou F. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet. 2004 Nov; 36(11):1133-7. PMID: 15514660.
      Citations:    
    29. Abiola O, Angel JM, Avner P, Bachmanov AA, Belknap JK, Bennett B, Blankenhorn EP, Blizard DA, Bolivar V, Brockmann GA, Buck KJ, Bureau JF, Casley WL, Chesler EJ, Cheverud JM, Churchill GA, Cook M, Crabbe JC, Crusio WE, Darvasi A, de Haan G, Dermant P, Doerge RW, Elliot RW, Farber CR, Flaherty L, Flint J, Gershenfeld H, Gibson JP, Gu J, Gu W, Himmelbauer H, Hitzemann R, Hsu HC, Hunter K, Iraqi FF, Jansen RC, Johnson TE, Jones BC, Kempermann G, Lammert F, Lu L, Manly KF, Matthews DB, Medrano JF, Mehrabian M, Mittlemann G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Mountz JD, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Paigen B, Palmer AA, Peirce JL, Pomp D, Rosemann M, Rosen GD, Schalkwyk LC, Seltzer Z, Settle S, Shimomura K, Shou S, Sikela JM, Siracusa LD, Spearow JL, Teuscher C, Threadgill DW, Toth LA, Toye AA, Vadasz C, Van Zant G, Wakeland E, Williams RW, Zhang HG, Zou F. The nature and identification of quantitative trait loci: a community's view. Nat Rev Genet. 2003 Nov; 4(11):911-6. PMID: 14634638.
      Citations:    
    30. Ghiselli G, Coffee N, Munnery CE, Koratkar R, Siracusa LD. The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway. J Biol Chem. 2003 May 30; 278(22):20259-67. PMID: 12651860.
      Citations:    
    31. Silverman KA, Koratkar RA, Siracusa LD, Buchberg AM. Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 (Mom2) locus. Mamm Genome. 2003 Feb; 14(2):119-29. PMID: 12584607.
      Citations:    
    32. Hagiwara N, Katarova Z, Siracusa LD, Brilliant MH. Nonneuronal expression of the GABA(A) beta3 subunit gene is required for normal palate development in mice. Dev Biol. 2003 Feb 1; 254(1):93-101. PMID: 12606284.
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    33. Koratkar R, Pequignot E, Hauck WW, Siracusa LD. The CAST/Ei strain confers significant protection against Apc(Min) intestinal polyps, independent of the resistant modifier of Min 1 (Mom1) locus. Cancer Res. 2002 Oct 1; 62(19):5413-7. PMID: 12359746.
      Citations:    
    34. Silverman KA, Koratkar R, Siracusa LD, Buchberg AM. Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia. Genome Res. 2002 Jan; 12(1):88-97. PMID: 11779834.
      Citations:    
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