Melvin Bosma

Title	Volunteer Faculty
Institution	Thomas Jefferson University
Department	Faculty Records and Publicatio - Thomas Jefferson University
Address	833 Chestnut Street Philadelphia PA 19023
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Research

research activities and funding

R01AI013323 (BOSMA, MELVIN J)May 1, 1976 - Jul 31, 1995 NIH SCID MICE AND THE CONTROL OF LYMPHOCYTE DIFFERENTIATION Role: Principal Investigator

R37CA004946 (BOSMA, MELVIN J)Dec 1, 1983 - May 31, 1996 NIH SEVERE COMBINED IMMUNODEFICIENCY IN THE MOUSE Role: Principal Investigator

R01CA004946 (BOSMA, MELVIN J)Dec 1, 1983 - Mar 31, 2007 NIH Control of Ig Gene Expression in Ig Transgenic Mice Role: Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Nakajima PB, Kiefer K, Price A, Bosma GC, Bosma MJ. Two distinct populations of H chain-edited B cells show differential surrogate L chain dependence. J Immunol. 2009 Mar 15; 182(6):3583-96. PMID: 19265137.

Citations:
Kiefer K, Nakajima PB, Oshinsky J, Seeholzer SH, Radic M, Bosma GC, Bosma MJ. Antigen receptor editing in anti-DNA transitional B cells deficient for surface IgM. J Immunol. 2008 May 01; 180(9):6094-106. PMID: 18424731.

Citations:
Kiefer K, Oshinsky J, Kim J, Nakajima PB, Bosma GC, Bosma MJ. The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination. Proc Natl Acad Sci U S A. 2007 Feb 20; 104(8):2843-8. PMID: 17296939.

Citations:
Bosma GC, Oshinsky J, Kiefer K, Nakajima PB, Charan D, Congelton C, Radic M, Bosma MJ. Development of functional B cells in a line of SCID mice with transgenes coding for anti-double-stranded DNA antibody. J Immunol. 2006 Jan 15; 176(2):889-98. PMID: 16393973.

Citations:
Bosma GC, Kim J, Urich T, Fath DM, Cotticelli MG, Ruetsch NR, Radic MZ, Bosma MJ. DNA-dependent protein kinase activity is not required for immunoglobulin class switching. J Exp Med. 2002 Dec 02; 196(11):1483-95. PMID: 12461083.

Citations:
Nakajima PB, Bosma MJ. Variable diversity joining recombination: nonhairpin coding ends in thymocytes of SCID and wild-type mice. J Immunol. 2002 Sep 15; 169(6):3094-104. PMID: 12218126.

Citations:
Ruetsch NR, Bosma GC, Bosma MJ. Unexpected rearrangement and expression of the immunoglobulin lambda1 locus in scid mice. J Exp Med. 2000 Jun 05; 191(11):1933-43. PMID: 10839808.

Citations:
Bosma GC, Chang Y, Karasuyama H, Bosma MJ. Differential effect of an Ig mu transgene on development of pre-B cells in fetal and adult SCID mice. Proc Natl Acad Sci U S A. 1999 Oct 12; 96(21):11952-7. PMID: 10518557.

Citations:
Chang Y, Bosma MJ, Bosma GC. Extended duration of DH-JH rearrangement in immunoglobulin heavy chain transgenic mice: implications for regulation of allelic exclusion. J Exp Med. 1999 Apr 19; 189(8):1295-305. PMID: 10209046.

Citations:
Berger MA, Dav? V, Rhodes MR, Bosma GC, Bosma MJ, Kappes DJ, Wiest DL. Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3 delta is physically associated but not functionally required. J Exp Med. 1997 Nov 03; 186(9):1461-7. PMID: 9348303.

Citations:
Nakajima PB, Bosma MJ. Characterization of excised DNA intermediates associated with V(D)J recombination at the T-cell receptor delta locus. Mol Cell Biol. 1997 May; 17(5):2631-41. PMID: 9111333.

Citations:
Chang Y, Bosma MJ. Effect of different Ig transgenes on B cell differentiation in scid mice. Int Immunol. 1997 Mar; 9(3):373-80. PMID: 9088976.

Citations:
Nakajima PB, Menetski JP, Roth DB, Gellert M, Bosma MJ. V-D-J rearrangements at the T cell receptor delta locus in mouse thymocytes of the alpha beta lineage. Immunity. 1995 Nov; 3(5):609-21. PMID: 7584151.

Citations:
Chang Y, Bosma GC, Bosma MJ. Development of B cells in scid mice with immunoglobulin transgenes: implications for the control of V(D)J recombination. Immunity. 1995 Jun; 2(6):607-16. PMID: 7796294.

Citations:
Fish SM, Bosma MJ. Abnormal deletions in the T-cell receptor delta locus of mouse thymocytes. Mol Cell Biol. 1994 Jul; 14(7):4455-64. PMID: 8007952.

Citations:
Kotloff DB, Bosma MJ, Ruetsch NR. V(D)J recombination in peritoneal B cells of leaky scid mice. J Exp Med. 1993 Dec 01; 178(6):1981-94. PMID: 8245777.

Citations:
Kotloff DB, Bosma MJ, Ruetsch NR. Scid mouse Pre-B cells with intracellular mu chains: analysis of recombinase activity and IgH gene rearrangements. Int Immunol. 1993 Apr; 5(4):383-91. PMID: 8494825.

Citations:
Reichman-Fried M, Bosma MJ, Hardy RR. B-lineage cells in mu-transgenic scid mice proliferate in response to IL-7 but fail to show evidence of immunoglobulin light chain gene rearrangement. Int Immunol. 1993 Mar; 5(3):303-10. PMID: 8466867.

Citations:
Roth DB, Menetski JP, Nakajima PB, Bosma MJ, Gellert M. V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell. 1992 Sep 18; 70(6):983-91. PMID: 1356077.

Citations:
Roth DB, Nakajima PB, Menetski JP, Bosma MJ, Gellert M. V(D)J recombination in mouse thymocytes: double-strand breaks near T cell receptor delta rearrangement signals. Cell. 1992 Apr 03; 69(1):41-53. PMID: 1313336.

Citations:
Bosma MJ. B and T cell leakiness in the scid mouse mutant. Immunodefic Rev. 1992; 3(4):261-76. PMID: 1449786.

Citations:
Roth DB, Nakajima PB, Menetski JP, Bosma MJ, Gellert M. Double-strand breaks associated with V(D)J recombination at the TCR delta locus in murine thymocytes. Curr Top Microbiol Immunol. 1992; 182:115-24. PMID: 1490345.

Citations:
Carroll AM, Bosma MJ. T-lymphocyte development in scid mice is arrested shortly after the initiation of T-cell receptor delta gene recombination. Genes Dev. 1991 Aug; 5(8):1357-66. PMID: 1869046.

Citations:
Schuler W, Ruetsch NR, Amsler M, Bosma MJ. Coding joint formation of endogenous T cell receptor genes in lymphoid cells from scid mice: unusual P-nucleotide additions in VJ-coding joints. Eur J Immunol. 1991 Mar; 21(3):589-96. PMID: 1849083.

Citations:
Bosma MJ, Carroll AM. The SCID mouse mutant: definition, characterization, and potential uses. Annu Rev Immunol. 1991; 9:323-50. PMID: 1910681.

Citations:
Petrini JH, Carroll AM, Bosma MJ. T-cell receptor gene rearrangements in functional T-cell clones from severe combined immune deficient (scid) mice: reversion of the scid phenotype in individual lymphocyte progenitors. Proc Natl Acad Sci U S A. 1990 May; 87(9):3450-3. PMID: 2159151.

Citations:
Reichman-Fried M, Hardy RR, Bosma MJ. Development of B-lineage cells in the bone marrow of scid/scid mice following the introduction of functionally rearranged immunoglobulin transgenes. Proc Natl Acad Sci U S A. 1990 Apr; 87(7):2730-4. PMID: 2320586.

Citations:
Schuler W, Schuler A, Bosma MJ. Defective V-to-J recombination of T cell receptor gamma chain genes in scid mice. Eur J Immunol. 1990 Mar; 20(3):545-50. PMID: 2156708.

Citations:
Carroll AM, Hardy RR, Bosma MJ. Occurrence of mature B (IgM+, B220+) and T (CD3+) lymphocytes in scid mice. J Immunol. 1989 Aug 15; 143(4):1087-93. PMID: 2473116.

Citations:
Gibson DM, Bosma GC, Bosma MJ. Limited clonal diversity of serum immunoglobulin in leaky scid mice. Curr Top Microbiol Immunol. 1989; 152:125-36. PMID: 2509142.

Citations:
Fried M, Hardy RR, Bosma MJ. Transgenic scid mice with a functionally rearranged immunoglobulin heavy chain gene. Curr Top Microbiol Immunol. 1989; 152:107-14. PMID: 2509141.

Citations:
Bosma GC, Davisson MT, Ruetsch NR, Sweet HO, Shultz LD, Bosma MJ. The mouse mutation severe combined immune deficiency (scid) is on chromosome 16. Immunogenetics. 1989; 29(1):54-7. PMID: 2908877.

Citations:
Carroll AM, Bosma MJ. Detection and characterization of functional T cells in mice with severe combined immune deficiency. Eur J Immunol. 1988 Dec; 18(12):1965-71. PMID: 2851447.

Citations:
Kim MG, Schuler W, Bosma MJ, Marcu KB. Abnormal recombination of Igh D and J gene segments in transformed pre-B cells of scid mice. J Immunol. 1988 Aug 15; 141(4):1341-7. PMID: 3135329.

Citations:
Schuler W, Schuler A, Lennon GG, Bosma GC, Bosma MJ. Transcription of unrearranged antigen receptor genes in scid mice. EMBO J. 1988 Jul; 7(7):2019-24. PMID: 2458253.

Citations:
Fulop GM, Bosma GC, Bosma MJ, Phillips RA. Early B-cell precursors in scid mice: normal numbers of cells transformable with Abelson murine leukemia virus (A-MuLV). Cell Immunol. 1988 Apr 15; 113(1):192-201. PMID: 2835169.

Citations:
Bosma GC, Fried M, Custer RP, Carroll A, Gibson DM, Bosma MJ. Evidence of functional lymphocytes in some (leaky) scid mice. J Exp Med. 1988 Mar 01; 167(3):1016-33. PMID: 3280724.

Citations:
Kim MG, Schuler W, Bosma MJ, Marcu KB. Aberrant Igh locus rearrangements in A-MuLV pre B lines of scid mice: evidence for deregulated D-J recombination. Curr Top Microbiol Immunol. 1988; 137:203-10. PMID: 3262041.

Citations:
Tutt MM, Schuler W, Kuziel WA, Tucker PW, Bennett M, Bosma MJ, Kumar V. T cell receptor genes do not rearrange or express functional transcripts in natural killer cells of scid mice. J Immunol. 1987 Apr 01; 138(7):2338-44. PMID: 3559207.

Citations:
Hackett J, Bosma GC, Bosma MJ, Bennett M, Kumar V. Transplantable progenitors of natural killer cells are distinct from those of T and B lymphocytes. Proc Natl Acad Sci U S A. 1986 May; 83(10):3427-31. PMID: 2871552.

Citations:
Marks R, Bosma MJ. Truncated mu (mu') chains in murine IgM. Evidence that mu' chains lack variable regions. J Exp Med. 1985 Dec 01; 162(6):1862-77. PMID: 2415657.

Citations:
Custer RP, Bosma GC, Bosma MJ. Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms. Am J Pathol. 1985 Sep; 120(3):464-77. PMID: 2412448.

Citations:
O'Toole MM, Bosma GC, Bosma MJ. Expression of murine Lm-1 locus. Lm-1 determinants on lymphocytes and macrophages, and effects of Lm-1 incompatibility on bone marrow grafts. J Exp Med. 1985 Aug 01; 162(2):607-24. PMID: 2410531.

Citations:
Dorshkind K, Pollack SB, Bosma MJ, Phillips RA. Natural killer (NK) cells are present in mice with severe combined immunodeficiency (scid). J Immunol. 1985 Jun; 134(6):3798-801. PMID: 3989296.

Citations:
Czitrom AA, Edwards S, Phillips RA, Bosma MJ, Marrack P, Kappler JW. The function of antigen-presenting cells in mice with severe combined immunodeficiency. J Immunol. 1985 Apr; 134(4):2276-80. PMID: 2579136.

Citations:
Dorshkind K, Keller GM, Phillips RA, Miller RG, Bosma GC, O'Toole M, Bosma MJ. Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease. J Immunol. 1984 Apr; 132(4):1804-8. PMID: 6607948.

Citations:
Bosma GC, Custer RP, Bosma MJ. A severe combined immunodeficiency mutation in the mouse. Nature. 1983 Feb 10; 301(5900):527-30. PMID: 6823332.

Citations:
Snodgrass HR, Wilson DB, Bosma MJ. T lymphocytes specific for immunoglobulin allotype. I. Igh-1b-specific T cells demonstrated by suppression in vivo and cytotoxicity in vitro. J Exp Med. 1981 Aug 01; 154(2):480-90. PMID: 6973605.

Citations:
Bosma GC, Owen J, Easton G, Marshall G, Dewitt C, Bosma MJ. Concentration of IgG1 and IgG2a allotypes in serum of nude and normal allotype-congenic mice. J Immunol. 1980 Feb; 124(2):879-84. PMID: 7188701.

Citations:
Brown AR, DeWitt CL, Bosma MJ, Nisonoff A. Dominance of an immune response by secondary cells: quantitation by allotype analysis. J Immunol. 1980 Jan; 124(1):250-4. PMID: 7350228.

Citations:
Bosma MJ, De Witt C, Hausman SJ. Serological distinciton of heavy chain variable regions (VH subgroups) of mouse immunoglobulins. I. Common VH determinants on the heavy chains of mouse myeloma proteins having different binding sites. J Exp Med. 1977 Oct 01; 146(4):104l-53. PMID: 70500.

Citations:
Bosma MJ, Bosma GC. Prevention of IgG2a production as a result of allotype-specific interaction between T and B cells. J Exp Med. 1977 Mar 01; 145(3):743-8. PMID: 233911.

Citations:
Bosma MJ, Bosma GC. Chronic suppression of immunoglobulin allotype production in adult congenic mice. Nature. 1976 Jan 29; 259(5541):313-5. PMID: 1082549.

Citations:
Bosma MJ, Marks R, De Witt CL. Quantitation of mouse immunoglobulin allotypes by a modified solid-phase radioimmune assay. J Immunol. 1975 Nov; 115(5):1381-6. PMID: 809514.

Citations:
Bosma MJ, Bosma GC. Congenic mouse strains: the expression of a hidden immunoglobulin allotype in a congenic partner strain of BALB-c mice. J Exp Med. 1974 Mar 01; 139(3):512-27. PMID: 4130242.

Citations:

Year	Publications
1997	3
1999	2
2000	1
2002	2
2006	1
2007	1
2008	1
2009	1

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Wiest, David

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