Thomas Jefferson University

Andrew Napper

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records and Publicatio - Thomas Jefferson University
Address833 Chestnut Street
Philadelphia PA 19023
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pak C, Simpson KJ, Weston AD, Cvijic ME, Evans K, Napper AD. Perspectives on phenotypic screening-Screen Design and Assay Technology Special Interest Group. SLAS Discov. 2024 03; 29(2):100146. PMID: 38311110.
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    2. Worthington P, Drake KM, Li Z, Napper AD, Pochan DJ, Langhans SA. Implementation of a High-Throughput Pilot Screen in Peptide Hydrogel-Based Three-Dimensional Cell Cultures. SLAS Discov. 2019 08; 24(7):714-723. PMID: 31039326.
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    3. Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, Weidner JR, Riss T, Trask OJ, Auld D, Dahlin JL, Devanaryan V, Foley TL, McGee J, Kahl SD, Kales SC, Arkin M, Baell J, Bejcek B, Gal-Edd N, Glicksman M, Haas JV, Iversen PW, Hoeppner M, Lathrop S, Sayers E, Liu H, Trawick B, McVey J, Lemmon VP, Li Z, McManus O, Minor L, Napper A, Wildey MJ, Pacifici R, Chin WW, Xia M, Xu X, Lal-Nag M, Hall MD, Michael S, Inglese J, Simeonov A, Austin CP. Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery. Clin Transl Sci. 2018 09; 11(5):461-470. PMID: 29877628.
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    4. Worthington P, Drake KM, Li Z, Napper AD, Pochan DJ, Langhans SA. Beta-hairpin hydrogels as scaffolds for high-throughput drug discovery in three-dimensional cell culture. Anal Biochem. 2017 10 15; 535:25-34. PMID: 28757092.
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    5. Cartledge DM, Robbins KM, Drake KM, Sternberg R, Stabley DL, Gripp KW, Kolb EA, Sol-Church K, Napper AD. Cytotoxicity of Zardaverine in Embryonal Rhabdomyosarcoma from a Costello Syndrome Patient. Front Oncol. 2017; 7:42. PMID: 28421158.
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    6. Napper AD. Discriminating High-Value Hits from PAINS. Assay Drug Dev Technol. 2016 Apr; 14(3):157. PMID: 27078676.
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    7. Napper AD. Interview with Jonathan Baell, PhD. Assay Drug Dev Technol. 2016 Apr; 14(3):164-7. PMID: 27078678.
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    8. Gopalakrishnapillai A, Kolb EA, Dhanan P, Mason RW, Napper A, Barwe SP. Disruption of Annexin II /p11 Interaction Suppresses Leukemia Cell Binding, Homing and Engraftment, and Sensitizes the Leukemia Cells to Chemotherapy. PLoS One. 2015; 10(10):e0140564. PMID: 26465153.
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    9. Napper AD, Mucke HA. A Special Focus on Drug Repurposing, Rescue, and Repositioning. Assay Drug Dev Technol. 2015 Jul-Aug; 13(6):293. PMID: 26241206.
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    10. Napper AD. Perspectives in ASSAY and Drug Development Technologies. Assay Drug Dev Technol. 2015 Jun; 13(5):241. PMID: 26168059.
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    11. Fu H, Napper AD. Interview with Haian Fu, PhD. Assay Drug Dev Technol. 2015 Jun; 13(5):249-53. PMID: 26168060.
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    12. Napper A. Spanning breadth and depth in ASSAY and Drug Development Technologies. Assay Drug Dev Technol. 2015 Mar; 13(2):57. PMID: 25785770.
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    13. Napper AD. A new chapter for ASSAY and drug development technologies. Assay Drug Dev Technol. 2015 Jan-Feb; 13(1):1. PMID: 25710541.
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    14. Glickman JF, Lundb?ck T, Napper AD, Niles WD, Simeonov A, Weaver CD, Yin HH, Zaman GJ, Osada H. Controversies in ASSAY and drug development technologies: a focus on assessing irreproducibility. Assay Drug Dev Technol. 2014 Oct; 12(8):443-51. PMID: 25383720.
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    15. Drake KM, Watson VG, Kisielewski A, Glynn R, Napper AD. A sensitive luminescent assay for the histone methyltransferase NSD1 and other SAM-dependent enzymes. Assay Drug Dev Technol. 2014 Jun; 12(5):258-71. PMID: 24927133.
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    16. Napper AD, Watson VG. Targeted drug discovery for pediatric leukemia. Front Oncol. 2013; 3:170. PMID: 23847761.
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    17. Burkhart RA, Peng Y, Norris ZA, Tholey RM, Talbott VA, Liang Q, Ai Y, Miller K, Lal S, Cozzitorto JA, Witkiewicz AK, Yeo CJ, Gehrmann M, Napper A, Winter JM, Sawicki JA, Zhuang Z, Brody JR. Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival. Mol Cancer Res. 2013 Aug; 11(8):901-11. PMID: 23696131.
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    18. Watson VG, Drake KM, Peng Y, Napper AD. Development of a high-throughput screening-compatible assay for the discovery of inhibitors of the AF4-AF9 interaction using AlphaScreen technology. Assay Drug Dev Technol. 2013 May; 11(4):253-68. PMID: 23679849.
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    19. Moorwood C, Lozynska O, Suri N, Napper AD, Diamond SL, Khurana TS. Drug discovery for Duchenne muscular dystrophy via utrophin promoter activation screening. PLoS One. 2011; 6(10):e26169. PMID: 22028826.
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    20. Napper AD, Sivendran S. Miniaturized High-Throughput Fluorescent Assay for Conversion of NAD(P)H to NAD(P). Curr Protoc Chem Biol. 2011 Jun 01; 3(2). PMID: 25478291.
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    21. Huang F, Motlekar NA, Burgwin CM, Napper AD, Diamond SL, Mazin AV. Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening. ACS Chem Biol. 2011 Jun 17; 6(6):628-35. PMID: 21428443.
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    22. Napper AD, Motlekar N, de Almeida RA, Pavitt GD. Parallel High-Throughput Automated Assays to Measure Cell Growth and Beta-Galactosidase Reporter Gene Expression in the Yeast Saccharomyces cerevisiae. Curr Protoc Chem Biol. 2011 Mar 01; 3(1):1-14. PMID: 23836585.
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    23. LaFleur MD, Lucumi E, Napper AD, Diamond SL, Lewis K. Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms. J Antimicrob Chemother. 2011 Apr; 66(4):820-6. PMID: 21393183.
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    24. Clifton JD, Lucumi E, Myers MC, Napper A, Hama K, Farber SA, Smith AB, Huryn DM, Diamond SL, Pack M. Identification of novel inhibitors of dietary lipid absorption using zebrafish. PLoS One. 2010 Aug 25; 5(8):e12386. PMID: 20811635.
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    25. Inglese J, Napper A, Auld D. Improving success by balanced critical evaluations of assay methods. Assay Drug Dev Technol. 2010 Aug; 8(4):1. PMID: 20804419.
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    26. Lucumi E, Darling C, Jo H, Napper AD, Chandramohanadas R, Fisher N, Shone AE, Jing H, Ward SA, Biagini GA, DeGrado WF, Diamond SL, Greenbaum DC. Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay. Antimicrob Agents Chemother. 2010 Sep; 54(9):3597-604. PMID: 20547797.
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    27. Napper AD. Society for biomolecular sciences - 16th annual conference & exhibition - advancing the science of drug discovery. IDrugs. 2010 Jun; 13(6):372-5. PMID: 20506057.
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    28. Sivendran S, Jones V, Sun D, Wang Y, Grzegorzewicz AE, Scherman MS, Napper AD, McCammon JA, Lee RE, Diamond SL, McNeil M. Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC). Bioorg Med Chem. 2010 Jan 15; 18(2):896-908. PMID: 19969466.
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    29. Motlekar N, de Almeida RA, Pavitt GD, Diamond SL, Napper AD. Discovery of chemical modulators of a conserved translational control pathway by parallel screening in yeast. Assay Drug Dev Technol. 2009 Oct; 7(5):479-94. PMID: 19715453.
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    30. Napper AD. Society for Biomolecular Sciences--15th Annual Conference. Bioassay and technology innovation: 15 years of shaping drug discovery. 26-30 April 2009, Lille, France. IDrugs. 2009 Jun; 12(6):363-5. PMID: 19517316.
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    31. Napper AD. An interview with Andrew D. Napper, Ph.D. Interview. Assay Drug Dev Technol. 2008 Oct; 6(5):611-20. PMID: 19035845.
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    32. Napper A. Drug Discovery and Development of Innovative Therapeutics--IBC's 13th Annual World Congress. Approaches to cancer therapy. IDrugs. 2008 Oct; 11(10):705-9. PMID: 18828066.
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    33. Napper A. Biochemical-Based Assays for HTS --CHI's 14th Annual Conference. IDrugs. 2008 Jul; 11(7):493-6. PMID: 18600595.
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    34. Motlekar N, Diamond SL, Napper AD. Evaluation of an orthogonal pooling strategy for rapid high-throughput screening of proteases. Assay Drug Dev Technol. 2008 Jun; 6(3):395-405. PMID: 18593377.
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    35. Myers MC, Shah PP, Beavers MP, Napper AD, Diamond SL, Smith AB, Huryn DM. Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype. Bioorg Med Chem Lett. 2008 Jun 15; 18(12):3646-51. PMID: 18499453.
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    36. Shah PP, Myers MC, Beavers MP, Purvis JE, Jing H, Grieser HJ, Sharlow ER, Napper AD, Huryn DM, Cooperman BS, Smith AB, Diamond SL. Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L. Mol Pharmacol. 2008 Jul; 74(1):34-41. PMID: 18403718.
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    37. de Almeida RA, Burgess D, Shema R, Motlekar N, Napper AD, Diamond SL, Pavitt GD. A Saccharomyces cerevisiae cell-based quantitative beta-galactosidase assay compatible with robotic handling and high-throughput screening. Yeast. 2008 Jan; 25(1):71-6. PMID: 17957822.
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    38. Myers MC, Napper AD, Motlekar N, Shah PP, Chiu CH, Beavers MP, Diamond SL, Huryn DM, Smith AB. Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays. Bioorg Med Chem Lett. 2007 Sep 01; 17(17):4761-6. PMID: 17656088.
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    39. Napper AD, Hixon J, McDonagh T, Keavey K, Pons JF, Barker J, Yau WT, Amouzegh P, Flegg A, Hamelin E, Thomas RJ, Kates M, Jones S, Navia MA, Saunders JO, DiStefano PS, Curtis R. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15; 48(25):8045-54. PMID: 16335928.
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    40. McDonagh T, Hixon J, DiStefano PS, Curtis R, Napper AD. Microplate filtration assay for nicotinamide release from NAD using a boronic acid resin. Methods. 2005 Aug; 36(4):346-50. PMID: 16085423.
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    41. Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK. Substrate-specific activation of sirtuins by resveratrol. J Biol Chem. 2005 Apr 29; 280(17):17038-45. PMID: 15684413.
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    42. Martin MT, Napper AD, Schultz PG, Rees AR. Mechanistic studies of a tyrosine-dependent catalytic antibody. Biochemistry. 1991 Oct 08; 30(40):9757-61. PMID: 1911763.
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