Anesthetics, Local

"Anesthetics, Local" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.

Descriptor ID	D000779
MeSH Number(s)	D27.505.696.277.100.200 D27.505.696.663.850.025 D27.505.954.427.210.100.200
Concept/Terms	Anesthetics, Local Anesthetics, Local Local Anesthetics Conduction-Blocking Anesthetics Conduction Blocking Anesthetics Anesthetics, Conduction-Blocking Anesthetics, Conduction Blocking Anesthetics, Topical Anesthetics, Topical

Below are MeSH descriptors whose meaning is more general than "Anesthetics, Local".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Physiological Effects of Drugs [D27.505.696]
Central Nervous System Depressants [D27.505.696.277]
Anesthetics [D27.505.696.277.100]
Anesthetics, Local [D27.505.696.277.100.200]
Peripheral Nervous System Agents [D27.505.696.663]
Sensory System Agents [D27.505.696.663.850]
Anesthetics, Local [D27.505.696.663.850.025]
Therapeutic Uses [D27.505.954]
Central Nervous System Agents [D27.505.954.427]
Central Nervous System Depressants [D27.505.954.427.210]
Anesthetics [D27.505.954.427.210.100]
Anesthetics, Local [D27.505.954.427.210.100.200]

Below are MeSH descriptors whose meaning is related to "Anesthetics, Local".

Below are MeSH descriptors whose meaning is more specific than "Anesthetics, Local".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Anesthetics, Local" by people in this website by year, and whether "Anesthetics, Local" was a major or minor topic of these publications.

Bar chart showing 87 publications over 26 distinct years, with a maximum of 8 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1997	3	0	3
1998	1	3	4
1999	2	0	2
2002	1	1	2
2003	1	1	2
2004	1	1	2
2005	2	1	3
2006	1	0	1
2007	1	1	2
2008	2	0	2
2009	1	3	4
2010	0	3	3
2012	1	0	1
2013	2	1	3
2014	5	0	5
2015	2	1	3
2016	3	2	5
2017	6	1	7
2018	4	2	6
2019	2	3	5
2020	1	7	8
2021	1	2	3
2022	2	3	5
2023	0	3	3
2024	1	1	2

Below are the most recent publications written about "Anesthetics, Local" by people in Profiles.

Kasper AA, Plusch K, Voskerijian A, Barnabei D, Rivlin M, Beredjiklian PK, Wang ML. Efficacy of Direct Versus Peripheral Adjuvant Dexamethasone on Duration and Rebound Pain in Regional Anesthesia for Outpatient Distal Radius Fracture Fixation: A Prospective Randomized Controlled Blinded Study. Hand (N Y). 2025 Oct; 20(7):1132-1137.

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Harrer S, Yayac M, Toci GR, Levicoff E, Courtney PM, Star AM, Saxena A. Efficacy of Liposomal Bupivacaine Versus a Traditional Local Anesthetic in Periarticular Injections during Total Hip Arthroplasty: A Systematic Review and Meta-analysis. J Surg Orthop Adv. 2024; 33(3):143-151.

View in: PubMed
Ezzedine D, Dhariwal L, Wasenda E, Salamon C, Caraballo R. Pudendal Nerve Block With Liposomal Bupivacaine for Sacrospinous Ligament Suspension. Urogynecology (Phila). 2024 02 01; 30(2):98-106.

View in: PubMed
Changoor S, Giakas A, Sacks K, Asma A, Lang RS, Yorgova P, Rogers K, Gabos PG, Shah SA. The Role of Liposomal Bupivacaine in Multimodal Pain Management Following Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis: Faster and Farther With Less Opioids. Spine (Phila Pa 1976). 2024 Jan 15; 49(2):E11-E16.

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Schwenk ES, Lam E, Abulfathi AA, Schmidt S, Gebhart A, Witzeling SD, Mohamod D, Sarna RR, Roy AB, Zhao JL, Kaushal G, Rochani A, Baratta JL, Viscusi ER. Population pharmacokinetic and safety analysis of ropivacaine used for erector spinae plane blocks. Reg Anesth Pain Med. 2023 09; 48(9):454-461.

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Fillingham YA, Hannon CP, Kopp SL, Austin MS, Sershon RA, Stronach BM, Meneghini RM, Abdel MP, Griesemer ME, Woznica A, Casambre FD, Nelson N, Hamilton WG, Della Valle CJ. The Efficacy and Safety of Regional Nerve Blocks in Total Knee Arthroplasty: Systematic Review and Direct Meta-Analysis. J Arthroplasty. 2022 10; 37(10):1906-1921.e2.

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Hannon CP, Fillingham YA, Spangehl MJ, Karas V, Kamath AF, Casambre FD, Verity TJ, Nelson N, Hamilton WG, Della Valle CJ. The Efficacy and Safety of Periarticular Injection in Total Joint Arthroplasty: A Direct Meta-Analysis. J Arthroplasty. 2022 10; 37(10):1928-1938.e9.

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Buddle VP, DeBernardis D, Lutsky KF, Beredjiklian PK, Matzon JL. Effectiveness of Corticosteroid Injections in Diabetic Patients With De Quervain Tenosynovitis. J Hand Surg Am. 2022 10; 47(10):979-987.

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Haffar A, Khan IA, Abdelaal MS, Banerjee S, Sharkey PF, Lonner JH. Topical Cannabidiol (CBD) After Total Knee Arthroplasty Does Not Decrease Pain or Opioid Use: A Prospective Randomized Double-Blinded Placebo-Controlled Trial. J Arthroplasty. 2022 09; 37(9):1763-1770.

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Callahan ZM, Roberts AL, Christopher AN, Gadomski SP, Kuchta KM, Costanzo CM, Phillips BR, Isenberg GA, Goldstein SD. The Effect of Commonly Used Local Anesthetic on Bacterial Growth. J Surg Res. 2022 06; 274:16-22.

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