Antifibrinolytic Agents

"Antifibrinolytic Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmins are known. The drugs are used to control massive hemorrhage and in other coagulation disorders.

Descriptor ID	D000933
MeSH Number(s)	D27.505.519.421.500 D27.505.954.502.270.463.091
Concept/Terms	Antifibrinolytic Agents Antifibrinolytic Agents Agents, Antifibrinolytic Antifibrinolytics Antifibrinolysins Plasmin Inhibitors Plasmin Inhibitors Inhibitors, Plasmin Antiplasmins Plasmin Inhibitor Inhibitor, Plasmin

Below are MeSH descriptors whose meaning is more general than "Antifibrinolytic Agents".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Fibrin Modulating Agents [D27.505.519.421]
Antifibrinolytic Agents [D27.505.519.421.500]
Therapeutic Uses [D27.505.954]
Hematologic Agents [D27.505.954.502]
Coagulants [D27.505.954.502.270]
Hemostatics [D27.505.954.502.270.463]
Antifibrinolytic Agents [D27.505.954.502.270.463.091]

Below are MeSH descriptors whose meaning is related to "Antifibrinolytic Agents".

Below are MeSH descriptors whose meaning is more specific than "Antifibrinolytic Agents".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Antifibrinolytic Agents" by people in this website by year, and whether "Antifibrinolytic Agents" was a major or minor topic of these publications.

Bar chart showing 40 publications over 15 distinct years, with a maximum of 7 publications in 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2008	1	0	1
2011	0	1	1
2012	2	0	2
2013	0	1	1
2014	1	1	2
2016	1	1	2
2017	2	1	3
2018	6	0	6
2019	1	3	4
2020	4	0	4
2021	3	0	3
2022	1	0	1
2023	2	0	2
2024	6	1	7

Below are the most recent publications written about "Antifibrinolytic Agents" by people in Profiles.

Leal J, Kugelman DN, Ward SA, Wixted CM, Lajam CM, Schwarzkopf R, Seyler TM. Total hip arthroplasty was found to be safe in Jehovah's Witness patients: a multi-centered matched study. Arch Orthop Trauma Surg. 2024 Dec 31; 145(1):103.

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Hohmann AL, Wilson AE, Schulte DM, Casambre FD, Della Valle CJ, Lonner JH, Fillingham YA. Fragility Index Analysis of the 2018 Clinical Practice Guidelines on Tranexamic Acid Use in Total Joint Arthroplasty. J Arthroplasty. 2025 Mar; 40(3):573-577.e3.

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Leal J, Kugelman DN, Ward SA, Wixted CM, Lajam CM, Seyler TM, Schwarzkopf R. Tranexamic Acid Led to Improved Safety of Total Knee Arthroplasty in Jehovah's Witness Patients: A Multicentered Matched Study. J Arthroplasty. 2025 Feb; 40(2):409-415.

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Marous CL, Wladis EJ. Reply Re: "Effects of Preoperative Intravenous Versus Subcutaneous Tranexamic Acid on Postoperative Periorbital Ecchymosis and Edema Following Upper Eyelid Blepharoplasty: A Prospective, Randomized, Double-Blinded, Placebo-Controlled, Comparative Study". Ophthalmic Plast Reconstr Surg. 2024 Jul-Aug 01; 40(4):471.

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Meghpara M, Goh GS, Fillingham YA. Response to Letter to the Editor on "Does the Use of Tranexamic Acid in Patients Who Have Preoperative Coagulopathy Undergoing Total Joint Arthroplasty Normalize Their Risk of Complications? A Matched Equivalence Analysis". J Arthroplasty. 2024 Jun; 39(6):e44-e45.

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Marous CL, Farhat OJ, Cefalu M, Rothschild MI, Alapati S, Wladis EJ. Effects of Preoperative Intravenous Versus Subcutaneous Tranexamic Acid on Postoperative Periorbital Ecchymosis and Edema Following Upper Eyelid Blepharoplasty: A Prospective, Randomized, Double-Blinded, Placebo-Controlled, Comparative Study. Ophthalmic Plast Reconstr Surg. 2024 Sep-Oct 01; 40(5):523-532.

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Musmar B, Orscelik A, Salim H, Adeeb N, Spellicy S, Abdelgadir J, Azar J, Cuellar-Saenz HH, Guthikonda B, Jabbour P, Hasan D. Efficacy and safety of tranexamic acid in the management of chronic subdural hematoma: a systematic review and meta-analysis. J Neurosurg. 2024 Oct 01; 141(4):945-954.

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Meghpara MM, Goh GS, Ciesielka KA, Fillingham YA. Does the Use of Tranexamic Acid in Patients Who Have Preoperative Coagulopathy Undergoing Total Joint Arthroplasty Normalize Their Risk of Complications? A Matched Equivalence Analysis. J Arthroplasty. 2023 11; 38(11):2264-2268.

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Brailovsky Y, Lakhter V, Newman J, Allen S, Elkaryoni A, Desai P, Masic D, Bechara CF, Bontekoe E, Hoppensteadt D, Lopez JJ, Siddiqui F, Iqbal O, Fareed J, Darki A. Fibrinolytic Status and Risk of Death After Acute Pulmonary Embolism. Clin Appl Thromb Hemost. 2023 Jan-Dec; 29:10760296231162079.

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Yoon U, Bartoszko J, Bezinover D, Biancofiore G, Forkin KT, Rahman S, Spiro M, Raptis DA, Kang Y. Intraoperative transfusion management, antifibrinolytic therapy, coagulation monitoring and the impact on short-term outcomes after liver transplantation-A systematic review of the literature and expert panel recommendations. Clin Transplant. 2022 10; 36(10):e14637.

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