Antimetabolites

"Antimetabolites" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033)

Descriptor ID	D000963
MeSH Number(s)	D27.505.519.186 D27.888.569.042
Concept/Terms	Antimetabolites Antimetabolites

Below are MeSH descriptors whose meaning is more general than "Antimetabolites".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Antimetabolites [D27.505.519.186]
Toxic Actions [D27.888]
Noxae [D27.888.569]
Antimetabolites [D27.888.569.042]

Below are MeSH descriptors whose meaning is related to "Antimetabolites".

Below are MeSH descriptors whose meaning is more specific than "Antimetabolites".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Antimetabolites" by people in this website by year, and whether "Antimetabolites" was a major or minor topic of these publications.

Bar chart showing 15 publications over 12 distinct years, with a maximum of 2 publications in 2001 and 2005 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	1	1	2
2003	0	1	1
2004	0	1	1
2005	0	2	2
2007	0	1	1
2008	1	0	1
2010	2	0	2
2011	1	0	1
2012	0	1	1
2016	1	0	1
2018	1	0	1
2023	0	1	1

Below are the most recent publications written about "Antimetabolites" by people in Profiles.

Kempen JH, Newcomb CW, Washington TL, Foster CS, Sobrin L, Thorne JE, Jabs DA, Suhler EB, Rosenbaum JT, Sen HN, Levy-Clarke GA, Nussenblatt RB, Bhatt NP, Lowder CY, Goldstein DA, Leiderman YI, Acharya NR, Holland GN, Read RW, Dunn JP, Dreger KA, Artornsombudh P, Begum HA, Fitzgerald TD, Kothari S, Payal AR, Daniel E, Gangaputra SS, Ka?maz RO, Liesegang TL, Pujari SS, Khachatryan N, Maghsoudlou A, Suga HK, Pak CM, Helzlsouer KJ, Buchanich JM. Use of Immunosuppression and the Risk of Subsequent Overall or Cancer Mortality. Ophthalmology. 2023 12; 130(12):1258-1268.

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Shin Y, Kokate R, Desai V, Bhushan A, Kaushal G. D-cycloserine nasal formulation development for anxiety disorders by using polymeric gels. Drug Discov Ther. 2018; 12(3):142-153.

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DuHadaway J, Prendergast GC. Antimetabolite TTL-315 selectively kills glucose-deprived cancer cells and enhances responses to cytotoxic chemotherapy in preclinical models of cancer. Oncotarget. 2016 Feb 16; 7(7):7372-80.

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Burke PA, Malebranche L, Gakhal M, Rahman E, Saltzberg M. Sustained improvement of cardiac function with immunosuppressive therapy in a case of acute lymphocytic myocarditis secondary to allopurinol induced Stevens-Johnson syndrome. Del Med J. 2012 Dec; 84(12):381-3.

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Melo AB, Spaeth GL. Trabeculectomy pearls of wisdom; mitomycin-soaked pledget 'necklace' suture. Eye (Lond). 2012 Jan; 26(1):173-4; author reply 174.

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Palejwala N, Ichhpujani P, Fakhraie G, Myers JS, Moster MR, Katz LJ. Single needle revision of failing filtration blebs: a retrospective comparative case series with 5-fluorouracil and mitomycin C. Eur J Ophthalmol. 2010 Nov-Dec; 20(6):1026-34.

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Melo AB, Spaeth GL. A new, safer method of applying antimetabolites during glaucoma filtering surgery. Ophthalmic Surg Lasers Imaging. 2010 May-Jun; 41(3):383-5.

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Galor A, Jabs DA, Leder HA, Kedhar SR, Dunn JP, Peters GB, Thorne JE. Comparison of antimetabolite drugs as corticosteroid-sparing therapy for noninfectious ocular inflammation. Ophthalmology. 2008 Oct; 115(10):1826-32.

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Agrawal A, Guttapalli A, Narayan S, Albert TJ, Shapiro IM, Risbud MV. Normoxic stabilization of HIF-1alpha drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk. Am J Physiol Cell Physiol. 2007 Aug; 293(2):C621-31.

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Smeyne M, Jiao Y, Shepherd KR, Smeyne RJ. Glia cell number modulates sensitivity to MPTP in mice. Glia. 2005 Nov 01; 52(2):144-52.

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