"Antimetabolites" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033)
| Descriptor ID |
D000963
|
| MeSH Number(s) |
D27.505.519.186 D27.888.569.042
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Antimetabolites".
Below are MeSH descriptors whose meaning is more specific than "Antimetabolites".
This graph shows the total number of publications written about "Antimetabolites" by people in this website by year, and whether "Antimetabolites" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2010 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Antimetabolites" by people in Profiles.
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DuHadaway J, Prendergast GC. Antimetabolite TTL-315 selectively kills glucose-deprived cancer cells and enhances responses to cytotoxic chemotherapy in preclinical models of cancer. Oncotarget. 2016 Feb 16; 7(7):7372-80.
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O'Donnell LA, Henkins KM, Kulkarni A, Matullo CM, Balachandran S, Pattisapu AK, Rall GF. Interferon gamma induces protective non-canonical signaling pathways in primary neurons. J Neurochem. 2015 Oct; 135(2):309-22.
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Burke PA, Malebranche L, Gakhal M, Rahman E, Saltzberg M. Sustained improvement of cardiac function with immunosuppressive therapy in a case of acute lymphocytic myocarditis secondary to allopurinol induced Stevens-Johnson syndrome. Del Med J. 2012 Dec; 84(12):381-3.
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Melo AB, Spaeth GL. Trabeculectomy pearls of wisdom; mitomycin-soaked pledget 'necklace' suture. Eye (Lond). 2012 Jan; 26(1):173-4; author reply 174.
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Palejwala N, Ichhpujani P, Fakhraie G, Myers JS, Moster MR, Katz LJ. Single needle revision of failing filtration blebs: a retrospective comparative case series with 5-fluorouracil and mitomycin C. Eur J Ophthalmol. 2010 Nov-Dec; 20(6):1026-34.
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Melo AB, Spaeth GL. A new, safer method of applying antimetabolites during glaucoma filtering surgery. Ophthalmic Surg Lasers Imaging. 2010 May-Jun; 41(3):383-5.
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DiPaola RS, Dvorzhinski D, Thalasila A, Garikapaty V, Doram D, May M, Bray K, Mathew R, Beaudoin B, Karp C, Stein M, Foran DJ, White E. Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy. Prostate. 2008 Dec 01; 68(16):1743-52.
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Galor A, Jabs DA, Leder HA, Kedhar SR, Dunn JP, Peters GB, Thorne JE. Comparison of antimetabolite drugs as corticosteroid-sparing therapy for noninfectious ocular inflammation. Ophthalmology. 2008 Oct; 115(10):1826-32.
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Agrawal A, Guttapalli A, Narayan S, Albert TJ, Shapiro IM, Risbud MV. Normoxic stabilization of HIF-1alpha drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk. Am J Physiol Cell Physiol. 2007 Aug; 293(2):C621-31.
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Smeyne M, Jiao Y, Shepherd KR, Smeyne RJ. Glia cell number modulates sensitivity to MPTP in mice. Glia. 2005 Nov 1; 52(2):144-52.