Arachidonate 12-Lipoxygenase
"Arachidonate 12-Lipoxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS.
Descriptor ID |
D001092
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MeSH Number(s) |
D08.811.682.690.416.583.500.060 D12.776.556.579.374.568.500.025
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Concept/Terms |
Arachidonate 12-Lipoxygenase- Arachidonate 12-Lipoxygenase
- 12-Lipoxygenase, Arachidonate
- Arachidonate 12 Lipoxygenase
- Arachidonic Acid 12-Lipoxygenase
- 12-Lipoxygenase, Arachidonic Acid
- Arachidonic Acid 12 Lipoxygenase
- 12-Lipoxygenase
- 12 Lipoxygenase
|
Below are MeSH descriptors whose meaning is more general than "Arachidonate 12-Lipoxygenase".
Below are MeSH descriptors whose meaning is more specific than "Arachidonate 12-Lipoxygenase".
This graph shows the total number of publications written about "Arachidonate 12-Lipoxygenase" by people in this website by year, and whether "Arachidonate 12-Lipoxygenase" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2010 | 1 | 0 | 1 |
2011 | 3 | 0 | 3 |
2014 | 1 | 0 | 1 |
2017 | 1 | 0 | 1 |
2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Arachidonate 12-Lipoxygenase" by people in Profiles.
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Tran M, Signorelli RL, Yamaguchi A, Chen E, Holinstat M, Iavarone AT, Offenbacher AR, Holman T. Biochemical and hydrogen-deuterium exchange studies of the single nucleotide polymorphism Y649C in human platelet 12-lipoxygenase linked to a bleeding disorder. Arch Biochem Biophys. 2023 01 01; 733:109472.
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Tourdot BE, Holinstat M. Targeting 12-Lipoxygenase as a Potential Novel Antiplatelet Therapy. Trends Pharmacol Sci. 2017 11; 38(11):1006-1015.
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Lieb DC, Brotman JJ, Hatcher MA, Aye MS, Cole BK, Haynes BA, Wohlgemuth SD, Fontana MA, Beydoun H, Nadler JL, Dobrian AD. Adipose tissue 12/15 lipoxygenase pathway in human obesity and diabetes. J Clin Endocrinol Metab. 2014 Sep; 99(9):E1713-20.
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Yeung J, Apopa PL, Vesci J, Kenyon V, Rai G, Jadhav A, Simeonov A, Holman TR, Maloney DJ, Boutaud O, Holinstat M. Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation. Mol Pharmacol. 2012 Mar; 81(3):420-30.
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Kenyon V, Rai G, Jadhav A, Schultz L, Armstrong M, Jameson JB, Perry S, Joshi N, Bougie JM, Leister W, Taylor-Fishwick DA, Nadler JL, Holinstat M, Simeonov A, Maloney DJ, Holman TR. Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. J Med Chem. 2011 Aug 11; 54(15):5485-97.
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Yeung J, Holinstat M. 12-lipoxygenase: a potential target for novel anti-platelet therapeutics. Cardiovasc Hematol Agents Med Chem. 2011 Jul 1; 9(3):154-64.
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Holinstat M, Boutaud O, Apopa PL, Vesci J, Bala M, Oates JA, Hamm HE. Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2a differently for cyclooxygenase-1 and 12-lipoxygenase catalysis. Arterioscler Thromb Vasc Biol. 2011 Feb; 31(2):435-42.