Arachidonate 12-Lipoxygenase

"Arachidonate 12-Lipoxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS.

Descriptor ID	D001092
MeSH Number(s)	D08.811.682.690.416.583.500.060 D12.776.556.579.374.568.500.025
Concept/Terms	Arachidonate 12-Lipoxygenase Arachidonate 12-Lipoxygenase 12-Lipoxygenase, Arachidonate Arachidonate 12 Lipoxygenase Arachidonic Acid 12-Lipoxygenase 12-Lipoxygenase, Arachidonic Acid Arachidonic Acid 12 Lipoxygenase 12-Lipoxygenase 12 Lipoxygenase

Below are MeSH descriptors whose meaning is more general than "Arachidonate 12-Lipoxygenase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
Oxygenases [D08.811.682.690]
Dioxygenases [D08.811.682.690.416]
Lipoxygenases [D08.811.682.690.416.583]
Arachidonate Lipoxygenases [D08.811.682.690.416.583.500]
Arachidonate 12-Lipoxygenase [D08.811.682.690.416.583.500.060]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Metalloproteins [D12.776.556]
Iron-Binding Proteins [D12.776.556.579]
Nonheme Iron Proteins [D12.776.556.579.374]
Lipoxygenases [D12.776.556.579.374.568]
Arachidonate Lipoxygenases [D12.776.556.579.374.568.500]
Arachidonate 12-Lipoxygenase [D12.776.556.579.374.568.500.025]

Below are MeSH descriptors whose meaning is related to "Arachidonate 12-Lipoxygenase".

Below are MeSH descriptors whose meaning is more specific than "Arachidonate 12-Lipoxygenase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Arachidonate 12-Lipoxygenase" by people in this website by year, and whether "Arachidonate 12-Lipoxygenase" was a major or minor topic of these publications.

Bar chart showing 18 publications over 12 distinct years, with a maximum of 3 publications in 2011 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	1	0	1
2010	1	0	1
2011	3	0	3
2012	1	0	1
2014	3	0	3
2016	1	0	1
2017	1	0	1
2018	1	0	1
2020	2	0	2
2021	0	1	1
2022	1	0	1
2023	1	1	2

Below are the most recent publications written about "Arachidonate 12-Lipoxygenase" by people in Profiles.

Mobbs JI, Black KA, Tran M, Burger WAC, Venugopal H, Holman TR, Holinstat M, Thal DM, Glukhova A. Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors. Blood. 2023 10 05; 142(14):1233-1242.

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Larsen HJ, Byrne D, ?zpolat T, Chauhan A, Bailey SL, Rhoads N, Reed F, Stolla MC, Adili R, Holinstat M, Fu X, Stolla M. Loss of 12-Lipoxygenase Improves the Post-Transfusion Function of Stored Platelets. Arterioscler Thromb Vasc Biol. 2023 10; 43(10):1990-2007.

View in: PubMed
Tran M, Signorelli RL, Yamaguchi A, Chen E, Holinstat M, Iavarone AT, Offenbacher AR, Holman T. Biochemical and hydrogen-deuterium exchange studies of the single nucleotide polymorphism Y649C in human platelet 12-lipoxygenase linked to a bleeding disorder. Arch Biochem Biophys. 2023 01 01; 733:109472.

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Tsai WC, Kalyanaraman C, Yamaguchi A, Holinstat M, Jacobson MP, Holman TR. In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2. Biochemistry. 2021 06 08; 60(22):1741-1754.

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Yeung J, Adili R, Yamaguchi A, Freedman CJ, Chen A, Shami R, Das A, Holman TR, Holinstat M. Omega-6 DPA and its 12-lipoxygenase-oxidized lipids regulate platelet reactivity in a nongenomic PPARa-dependent manner. Blood Adv. 2020 09 22; 4(18):4522-4537.

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Freedman C, Tran A, Tourdot BE, Kalyanaraman C, Perry S, Holinstat M, Jacobson MP, Holman TR. Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators. Biochemistry. 2020 05 19; 59(19):1832-1844.

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Green AR, Freedman C, Tena J, Tourdot BE, Liu B, Holinstat M, Holman TR. 5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1. Biochemistry. 2018 12 04; 57(48):6726-6734.

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Tourdot BE, Holinstat M. Targeting 12-Lipoxygenase as a Potential Novel Antiplatelet Therapy. Trends Pharmacol Sci. 2017 11; 38(11):1006-1015.

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Yeung J, Tourdot BE, Adili R, Green AR, Freedman CJ, Fernandez-Perez P, Yu J, Holman TR, Holinstat M. 12(S)-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-?-Linolenic Acid, Inhibits Thrombosis via Gas Signaling in Platelets. Arterioscler Thromb Vasc Biol. 2016 10; 36(10):2068-77.

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Yeung J, Tourdot BE, Fernandez-Perez P, Vesci J, Ren J, Smyrniotis CJ, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, McKenzie SE, Holinstat M. Platelet 12-LOX is essential for Fc?RIIa-mediated platelet activation. Blood. 2014 Oct 02; 124(14):2271-9.

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