"Cholera Toxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
| Descriptor ID |
D002772
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| MeSH Number(s) |
D08.811.913.400.725.115.180 D23.946.123.194 D23.946.330.150
|
| Concept/Terms |
Cholera Toxin- Cholera Toxin
- Toxin, Cholera
- Cholera Exotoxin
- Exotoxin, Cholera
- Choleragen
- Cholera Enterotoxin CT
- CT, Cholera Enterotoxin
- Enterotoxin CT, Cholera
Choleragenoid- Choleragenoid
- Cholera Toxin Protomer B
- Cholera Toxin B Subunit
|
Below are MeSH descriptors whose meaning is more general than "Cholera Toxin".
Below are MeSH descriptors whose meaning is more specific than "Cholera Toxin".
This graph shows the total number of publications written about "Cholera Toxin" by people in this website by year, and whether "Cholera Toxin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cholera Toxin" by people in Profiles.
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Eisenman LM. Ethanol and vestibular stimulation reveal simple and complex aspects of cerebellar heterogeneity. Cerebellum. 2011 Sep; 10(3):475-83.
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Mattsson J, Yrlid U, Stensson A, Sch?n K, Karlsson MC, Ravetch JV, Lycke NY. Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant. J Immunol. 2011 Oct 01; 187(7):3641-52.
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Maheshwari R, Levenson EA, Kiick KL. Manipulation of electrostatic and saccharide linker interactions in the design of efficient glycopolypeptide-based cholera toxin inhibitors. Macromol Biosci. 2010 Jan 11; 10(1):68-81.
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Bergström M, Liu S, Kiick KL, Ohlson S. Cholera toxin inhibitors studied with high-performance liquid affinity chromatography: a robust method to evaluate receptor-ligand interactions. Chem Biol Drug Des. 2009 Jan; 73(1):132-41.
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Portocarrero C, Markley K, Koprowski H, Spitsin S, Golovkin M. Immunogenic properties of plant-derived recombinant smallpox vaccine candidate pB5. Vaccine. 2008 Oct 09; 26(43):5535-40.
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Golovkin M, Spitsin S, Andrianov V, Smirnov Y, Xiao Y, Pogrebnyak N, Markley K, Brodzik R, Gleba Y, Isaacs SN, Koprowski H. Smallpox subunit vaccine produced in Planta confers protection in mice. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6864-9.
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Chahdi A, Sorokin A. Endothelin 1 stimulates beta1Pix-dependent activation of Cdc42 through the G(salpha) pathway. Exp Biol Med (Maywood). 2006 Jun; 231(6):761-5.
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Polizzotti BD, Kiick KL. Effects of polymer structure on the inhibition of cholera toxin by linear polypeptide-based glycopolymers. Biomacromolecules. 2006 Feb; 7(2):483-90.
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Gabison EE, Mourah S, Steinfels E, Yan L, Hoang-Xuan T, Watsky MA, De Wever B, Calvo F, Mauviel A, Menashi S. Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction. Am J Pathol. 2005 Jan; 166(1):209-19.
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Chen H, Tliba O, Van Besien CR, Panettieri RA, Amrani Y. TNF-[alpha] modulates murine tracheal rings responsiveness to G-protein-coupled receptor agonists and KCl. J Appl Physiol. 2003 Aug; 95(2):864-72; discussion 863.