Sirtuins

"Sirtuins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.

Descriptor ID	D037761
MeSH Number(s)	D08.811.277.087.520.200.650 D08.811.913.400.725.115.961 D12.776.476.900
Concept/Terms	Sirtuins Sirtuins Sir2-like Proteins Sir2 like Proteins Silent Mating Type Information Regulator 2-like Proteins Silent Mating Type Information Regulator 2 like Proteins

Below are MeSH descriptors whose meaning is more general than "Sirtuins".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Amidohydrolases [D08.811.277.087]
Histone Deacetylases [D08.811.277.087.520]
Group III Histone Deacetylases [D08.811.277.087.520.200]
Sirtuins [D08.811.277.087.520.200.650]
Transferases [D08.811.913]
Glycosyltransferases [D08.811.913.400]
Pentosyltransferases [D08.811.913.400.725]
ADP Ribose Transferases [D08.811.913.400.725.115]
Sirtuins [D08.811.913.400.725.115.961]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Sirtuins [D12.776.476.900]

Below are MeSH descriptors whose meaning is related to "Sirtuins".

Below are MeSH descriptors whose meaning is more specific than "Sirtuins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Sirtuins" by people in this website by year, and whether "Sirtuins" was a major or minor topic of these publications.

Bar chart showing 7 publications over 5 distinct years, with a maximum of 3 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	3	0	3
2007	0	1	1
2009	0	1	1
2020	1	0	1
2022	1	0	1

Below are the most recent publications written about "Sirtuins" by people in Profiles.

Cozzolino M, Herraiz S, Titus S, Roberts L, Romeu M, Peinado I, Scott RT, Pellicer A, Seli E. Transcriptomic landscape of granulosa cells and peripheral blood mononuclear cells in women with PCOS compared to young poor responders and women with normal response. Hum Reprod. 2022 05 30; 37(6):1274-1286.

View in: PubMed
Garcia-Peterson LM, Ndiaye MA, Chhabra G, Singh CK, Guzm?n-P?rez G, Iczkowski KA, Ahmad N. CRISPR/Cas9-mediated Knockout of SIRT6 Imparts Remarkable Antiproliferative Response in Human Melanoma Cells in vitro and in vivo. Photochem Photobiol. 2020 11; 96(6):1314-1320.

View in: PubMed
Wu K, Katiyar S, Witkiewicz A, Li A, McCue P, Song LN, Tian L, Jin M, Pestell RG. The cell fate determination factor dachshund inhibits androgen receptor signaling and prostate cancer cellular growth. Cancer Res. 2009 Apr 15; 69(8):3347-55.

View in: PubMed
Bickenbach KA, Veerapong J, Shao MY, Mauceri HJ, Posner MC, Kron SJ, Weichselbaum RR. Resveratrol is an effective inducer of CArG-driven TNF-alpha gene therapy. Cancer Gene Ther. 2008 Mar; 15(3):133-9.

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Napper AD, Hixon J, McDonagh T, Keavey K, Pons JF, Barker J, Yau WT, Amouzegh P, Flegg A, Hamelin E, Thomas RJ, Kates M, Jones S, Navia MA, Saunders JO, DiStefano PS, Curtis R. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15; 48(25):8045-54.

View in: PubMed
McDonagh T, Hixon J, DiStefano PS, Curtis R, Napper AD. Microplate filtration assay for nicotinamide release from NAD using a boronic acid resin. Methods. 2005 Aug; 36(4):346-50.

View in: PubMed
Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK. Substrate-specific activation of sirtuins by resveratrol. J Biol Chem. 2005 Apr 29; 280(17):17038-45.

View in: PubMed

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