Cholinesterase Inhibitors

"Cholinesterase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.

Descriptor ID	D002800
MeSH Number(s)	D27.505.519.389.275 D27.505.519.625.120.300 D27.505.696.577.120.300
Concept/Terms	Cholinesterase Inhibitors Cholinesterase Inhibitors Inhibitors, Cholinesterase Anticholinesterase Drugs Drugs, Anticholinesterase Anticholinesterases Anticholinesterase Agents Agents, Anticholinesterase Anti-Cholinesterases Anti Cholinesterases Cholinesterase Inhibitors, Irreversible Cholinesterase Inhibitors, Irreversible Inhibitors, Irreversible Cholinesterase Irreversible Cholinesterase Inhibitors Cholinesterase Inhibitors, Reversible Cholinesterase Inhibitors, Reversible Inhibitors, Reversible Cholinesterase Reversible Cholinesterase Inhibitors Acetylcholinesterase Inhibitors Acetylcholinesterase Inhibitors Inhibitors, Acetylcholinesterase

Below are MeSH descriptors whose meaning is more general than "Cholinesterase Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Cholinesterase Inhibitors [D27.505.519.389.275]
Neurotransmitter Agents [D27.505.519.625]
Cholinergic Agents [D27.505.519.625.120]
Cholinesterase Inhibitors [D27.505.519.625.120.300]
Physiological Effects of Drugs [D27.505.696]
Neurotransmitter Agents [D27.505.696.577]
Cholinergic Agents [D27.505.696.577.120]
Cholinesterase Inhibitors [D27.505.696.577.120.300]

Below are MeSH descriptors whose meaning is related to "Cholinesterase Inhibitors".

Below are MeSH descriptors whose meaning is more specific than "Cholinesterase Inhibitors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cholinesterase Inhibitors" by people in this website by year, and whether "Cholinesterase Inhibitors" was a major or minor topic of these publications.

Bar chart showing 17 publications over 12 distinct years, with a maximum of 2 publications in 2006 and 2007 and 2008 and 2010 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	1	0	1
2005	1	0	1
2006	1	1	2
2007	1	1	2
2008	2	0	2
2009	0	1	1
2010	2	0	2
2011	1	0	1
2013	1	1	2
2017	0	1	1
2021	1	0	1
2023	0	1	1

Below are the most recent publications written about "Cholinesterase Inhibitors" by people in Profiles.

Massoudi N, Mohit B, Fathi M, Nooraei N, Hannani KK, ArianNik M. The impact of rivastigmine on post-surgical delirium and cognitive impairment; a randomized clinical trial. Int J Geriatr Psychiatry. 2023 07; 38(7):e5970.

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Llad? A, Froelich L, Khandker RK, Roset M, Black CM, Lara N, Chekani F, Ambegaonkar BM. Assessing the Progression of Alzheimer's Disease in Real-World Settings in Three European Countries. J Alzheimers Dis. 2021; 80(2):749-759.

View in: PubMed
Fink HA, Jutkowitz E, McCarten JR, Hemmy LS, Butler M, Davila H, Ratner E, Calvert C, Barclay TR, Brasure M, Nelson VA, Kane RL. Pharmacologic Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review. Ann Intern Med. 2018 01 02; 168(1):39-51.

View in: PubMed
Woodward MR, Harper DG, Stolyar A, Forester BP, Ellison JM. Dronabinol for the treatment of agitation and aggressive behavior in acutely hospitalized severely demented patients with noncognitive behavioral symptoms. Am J Geriatr Psychiatry. 2014 Apr; 22(4):415-9.

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Cao J, Xia X, Dai X, Xiao J, Wang Q, Andrae-Marobela K, Okatch H. Flavonoids profiles, antioxidant, acetylcholinesterase inhibition activities of extract from Dryoathyrium boryanum (Willd.) Ching. Food Chem Toxicol. 2013 May; 55:121-8.

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Stefanacci RG. The costs of Alzheimer's disease and the value of effective therapies. Am J Manag Care. 2011 Nov; 17 Suppl 13:S356-62.

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Irwin D, Lippa CF, Rosso A. Effects of prescribed medications on cognition and behavior in frontotemporal lobar degeneration. Am J Alzheimers Dis Other Demen. 2010 Nov; 25(7):566-71.

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Lippa CF. Interventions and diagnostics in Alzheimer's disease and related conditions. Am J Alzheimers Dis Other Demen. 2010 Mar; 25(2):107-8.

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Samanta U, Kirby SD, Srinivasan P, Cerasoli DM, Bahnson BJ. Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes. Biochem Pharmacol. 2009 Aug 15; 78(4):420-9.

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Holtzheimer PE, Meeks TW, Kelley ME, Mufti M, Young R, McWhorter K, Vito N, Chismar R, Quinn S, Dey S, Byrd EH, McDonald WM. A double blind, placebo-controlled pilot study of galantamine augmentation of antidepressant treatment in older adults with major depression. Int J Geriatr Psychiatry. 2008 Jun; 23(6):625-31.

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