"Cocaine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
| Descriptor ID |
D003042
|
| MeSH Number(s) |
D02.145.074.722.388 D03.132.889.354 D03.605.084.500.722.388 D03.605.869.388
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cocaine".
Below are MeSH descriptors whose meaning is more specific than "Cocaine".
This graph shows the total number of publications written about "Cocaine" by people in this website by year, and whether "Cocaine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 4 | 0 | 4 |
| 1997 | 9 | 0 | 9 |
| 1998 | 4 | 0 | 4 |
| 1999 | 3 | 0 | 3 |
| 2000 | 3 | 0 | 3 |
| 2001 | 1 | 0 | 1 |
| 2002 | 2 | 1 | 3 |
| 2003 | 8 | 1 | 9 |
| 2004 | 3 | 1 | 4 |
| 2005 | 5 | 0 | 5 |
| 2006 | 3 | 2 | 5 |
| 2007 | 2 | 1 | 3 |
| 2008 | 7 | 0 | 7 |
| 2009 | 9 | 2 | 11 |
| 2010 | 7 | 1 | 8 |
| 2011 | 4 | 2 | 6 |
| 2012 | 1 | 1 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 1 | 2 |
| 2015 | 2 | 0 | 2 |
| 2016 | 4 | 0 | 4 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Cocaine" by people in Profiles.
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Di Trana A, Berardinelli D, Montanari E, Berretta P, Basile G, Huestis MA, Busard? FP. Molecular Insights and Clinical Outcomes of Drugs of Abuse Adulteration: New Trends and New Psychoactive Substances. Int J Mol Sci. 2022 Nov 23; 23(23).
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Ahmed ST, Nuni O, Tirumanisetty P, Zhao Y, Alhasson H, Mubasher M, Alweis R. Skin Necrosis Caused by Levamisole-Adulterated Cocaine. Am J Ther. 2021 Mar-Apr 01; 28(2):e263-e265.
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Carlier J, La Maida N, Di Trana A, Huestis MA, Pichini S, Busard? FP. Testing Unconventional Matrices to Monitor for Prenatal Exposure to Heroin, Cocaine, Amphetamines, Synthetic Cathinones, and Synthetic Opioids. Ther Drug Monit. 2020 04; 42(2):205-221.
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Desrosiers NA, Huestis MA. Oral Fluid Drug Testing: Analytical Approaches, Issues and Interpretation of Results. J Anal Toxicol. 2019 Jul 24; 43(6):415-443.
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Cotto B, Li H, Tuma RF, Ward SJ, Langford D. Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production. Neurobiol Dis. 2018 09; 117:28-41.
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Bouhlal S, Ellefsen KN, Sheskier MB, Singley E, Pirard S, Gorelick DA, Huestis MA, Leggio L. Acute effects of intravenous cocaine administration on serum concentrations of ghrelin, amylin, glucagon-like peptide-1, insulin, leptin and peptide YY and relationships with cardiorespiratory and subjective responses. Drug Alcohol Depend. 2017 11 01; 180:68-75.
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Richards JR, Hollander JE, Ramoska EA, Fareed FN, Sand IC, Izquierdo G?mez MM, Lange RA. ?-Blockers, Cocaine, and the Unopposed a-Stimulation Phenomenon. J Cardiovasc Pharmacol Ther. 2017 05; 22(3):239-249.
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Ellefsen KN, Concheiro M, Pirard S, Gorelick DA, Huestis MA. Pharmacodynamic effects and relationships to plasma and oral fluid pharmacokinetics after intravenous cocaine administration. Drug Alcohol Depend. 2016 Jun 01; 163:116-25.
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Ellefsen KN, Concheiro M, Pirard S, Gorelick DA, Huestis MA. Cocaine and benzoylecgonine oral fluid on-site screening and confirmation. Drug Test Anal. 2016 Mar-Apr; 8(3-4):296-303.
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Ellefsen KN, Concheiro M, Pirard S, Gorelick DA, Huestis MA. Oral fluid cocaine and benzoylecgonine concentrations following controlled intravenous cocaine administration. Forensic Sci Int. 2016 Mar; 260:95-101.